 | Joe Rogan als Himself - Host |
 | Ralph Abraham als Himself - Mathematician |
| Joel Bakst als Himself - Rabbi |
| Steven Barker als Himself - Pharmacologist |
| Cynthia Geist als Herself - DMT Study Nurse |
| Susan Blumenthal als Herself - DMT Volunteer |
| Patricio Dominguez als Himself - DMT Volunteer |
| Neal Goldsmith als Himself - Psychologist |
 | Alex Grey als Himself - Artist |
 | Roland Griffiths als Himself - Behavioral Pharmocologist |
| Charles Grob als Himself - Psychiatrist |
| Kathleen Harrison als Herself - Ethnobotanist |
 | Terence McKenna als Himself - Writer & Cultural Commentator (archive footage) |
| Erik Davis als Himself - Writer |
 | Graham Hancock als Himself - Writer |
| James Kent als Himself - Writer |
 | Dennis J. McKenna als Himself - Ethnopharmacologist |
 | Ralph Metzner als Himself - Psychologist |
| Christian Meuli als Himself - DMT Volunteer, Family Physician |
 | Jeremy Narby als Himself - Anthropologist |
| Andrew Newberg als Himself - Radiologist |
 | David Nichols als Himself - Medicinal Chemist |
| Daniel Pinchbeck als Himself - Writer |
 | Douglas Rushkoff als Himself - Writer |
| Spiros Antonopoulos als Himself - DMT Volunteer, Yoga Student |
| Leanna Standish als Herself - Naturopathic Physician |
| Andrew Stone als Himself - DMT Volunteer, Software Developer |
 | Rick Strassman als Himself - Psychiatrist |
| Robert Weisz als Himself - DMT Volunteer, Clinical Psychiatrist |
| Ricardo Amaringo als Himself |
| Alvin Joseph als Himself |
| Jon Levin als Himself |
| Aja Loux als Herself |
| José Pineda Vargas als Himself |
| Jordan Phillips als Herself |
| Jose Plaza als Himself |
| Mitch Schultz als Himself |
| Rob Velez als Himself |
| Fermin Quintuna als Himself |
| Ede Frecska als Himself - Psychopharmacologist |
| Rick Strassman | Writer |
| Mitch Schultz | Director |
| Mitch Schultz | Writer |
| Bart Bryant | Production Design |
| Rick Strassman | Producer |
| D.E. Ward | Sound Designer |
| David Hobizal | Animation Department Coordinator |
| David Schommer | Music |
| Deena Kalai | Legal Services |
| Kevin Nguyen | Production Office Assistant |
| Andrew Shinjang Lee | Producer |
| Spot Draves | VFX Artist |
| Ricardo Diaz | Additional Photography |
| Kerri Smeltzer | Production Manager |
| Nevie Owens | Editor |
| Chris Ohlson | Line Producer |
| Matt Ehling | Director of Photography |
| Laela Kilbourn | Additional Camera |
| Jordan Haro | Production Intern |
| Joe Malina | Color Designer |
| Justin Corsbie | Executive Producer |
| Craig Garansuay | Executive Producer |
| Glenn Eanes | Sound |
| Morgan Gillio | Set Designer |
| Mitch Schultz | Producer |
| Bryan Ferguson | Assistant Director |
| Tom Hammond | Sound Mixer |
| Bug Davidson | Production Intern |
