 | Alyson Stoner als Holly Hobbie (voice) |
 | Liliana Mumy als Amy Morris (voice) |
 | Tinashe als Carrie Baker (voice) |
 | Jansen Panettiere als Robby Hobbie (voice) |
 | Paul Butcher als Kyle Morris (voice) |
 | Rusty Schwimmer als Aunt Jessie Beech (voice) |
 | Jane Lynch als Joan Hobbie / Minnie (voice) |
| Diedrich Bader als Uncle Dave Beech (voice) |
 | Michael McShane als Jim Bidderman / Station Manager (voice) |
 | Rob Paulsen als Gary Hobbie / Mr. Valcucci / Tad (voice) (as Rob Paulson) |
 | Dee Bradley Baker als Willy Scranton / Bud Cartwright / Cheddar / Doodles / Bonnet |
 | Kim Mai Guest als Devon (voice) |
 | Bill Mumy als Bud Morris (voice) |
| Mario Piluso | Director |
| Eryk Casemiro | Writer |
| Mario Piluso | Supervising Producer |
| Jared Faber | Music |
| Rick Hinson | Supervising Sound Editor |
| Jason Stiff | Post Production Supervisor |
| Sparky Chen | Animation Supervisor |
| Tina Chen | Color Grading |
| Jim Chou | Background Designer |
| Virginia Hawes | Lead Character Designer |
| Frank Juang | Animation Supervisor |
| Gordon Kent | Animation |
| Christine Kolosov | Animation |
| Mori Lee | Animation Supervisor |
| Sam Lin | Layout Supervisor |
| Ago Liu | Background Designer |
| Vincent Liu | Layout Supervisor |
| Duck Ma | Assistant Art Director |
| Kevin Petrilak | Animation |
| Brenda Piluso | Animation |
| Andrew Shei | Animation Supervisor |
| Ricky Shen | Animation Supervisor |
| Kunio Shimamura | Animation |
| Tim Yeh | Animation Supervisor |
| Jack Yen | Director |
| Sara Yen | Background Designer |
| Monte Young | Animation Director |
| Kate Boutilier | Writer |