 | Bill Pullman als Fred Madison |
 | Patricia Arquette als Renee Madison / Alice Wakefield |
 | Balthazar Getty als Pete Dayton |
 | Robert Blake als Mystery Man |
 | Robert Loggia als Mr. Eddy / Dick Laurent |
 | Michael Massee als Andy |
 | Natasha Gregson Wagner als Sheila |
 | Richard Pryor als Arnie |
 | Gary Busey als Bill Dayton |
 | Lucy Butler als Candace Dayton |
 | Jack Nance als Phil |
 | Jack Kehler als Guard Johnny Mack |
 | Henry Rollins als Guard Henry |
 | Giovanni Ribisi als Steve "V" |
 | Scott Coffey als Teddy |
 | John Roselius als Al |
 | Louis Eppolito als Ed |
| Jenna Maetlind als Party Girl |
 | Michael Shamus Wiles als Guard Mike |
 | Mink Stole als Forewoman |
 | Leonard Termo als Judge |
 | Ivory Ocean als Guard Ivory |
 | David Byrd als Doctor Smordin |
 | Gene Ross als Warden Clements |
 | F. William Parker als Captain Luneau |
 | Guy Siner als Prison Official #1 |
 | Alexander Folk als Prison Official #2 |
| Carl Sundstrom als Hank |
| John Solari als Lou |
| Jack als The Dog |
| Al Garrett als Carl |
 | Heather Stephens als Lanie |
 | Amanda Anka als Girl #1 |
| Jennifer Syme als Junkie Girl |
 | Matt Sigloch als Assistant #1 |
 | Gilbert B. Combs als Assistant #2 |
 | Greg Travis als Tail Gate Driver |
 | Lisa Boyle als Marian |
 | Leslie Bega als Raquel |
 | Marilyn Manson als Porno Star #1 |
 | Jeordie White als Porno Star #2 |
| Metin Bereketli als Hitman (uncredited) |
 | Dru Berrymore als Blonde on Staircase (uncredited) |
 | Bill McAdams Jr. als Bartender (uncredited) |
| Lou Slaughter als Slickster (uncredited) |
| David Lynch | Director |
| Deepak Nayar | Unit Production Manager |
| Sabrina S. Sutherland | Production Supervisor |
| Cori Glazer | Script Supervisor |
| Leslie Morales | Set Decoration |
| Debbie Zoller | Makeup Artist |
| Paul Hughen | Camera Operator |
| Suzanne Tenner | Still Photographer |
| Michael LaViolette | Gaffer |
| John Willis III | Best Boy Electric |
| Philip Sloan | Grip |
| Tim Collins | Grip |
| Todd Griffith | Grip |
| Paul Wilkowsky | Grip |
| William Roy Eckert | Grip |
| Susumu Tokunow | Sound mixer |
| Kevin Kubota | Boom Operator |
| Julie Duvic | Location Manager |
| Karen R. Sachs | Production Manager |
| Cynthia Wise | Production Accountant |
| Desmond Cannon | Post Production Supervisor |
| David Lynch | Sound Designer |
| Frank Gaeta | Supervising Sound Editor |
| John Ross | Sound Re-Recording Mixer |
| Frank Gaeta | Sound Re-Recording Mixer |
| Derek Marcil | Sound Re-Recording Mixer |
| David Lynch | Sound Re-Recording Mixer |
| Javier Bennassar | Sound Effects Editor |
| David Melhase | Sound Effects Editor |
| Benjamin L. Cook | Sound Effects Editor |
| Cormac Funge | Sound Effects Editor |
| Elmo Weber | Sound Effects Editor |
| Bill Brown | Sound Effects Editor |
| Dean Hovey | Sound Effects Editor |
| Frederick Howard | Sound Effects Editor |
| Marc Vanocur | Music Editor |
| Derek Marcil | ADR & Dubbing |
| Mary Erstad | Foley |
| Ossama Khuluki | Foley |
| Catherine Harper | Foley |
| Christopher Moriana | Foley |
| Ellen Heuer | Foley |
| Cassandra King | Post Production Assistant |
| David A. Poole | Special Effects |
| Michael Wilmot | Special Effects |
| Bart Barber | Special Effects |
| Greg Polutonovich | Sculptor |
| Ed Morris | Executive Consultant |
| Jiří Zobač | Sound Engineer |
| Johanna Ray | Casting |
| Elaine J. Huzzar | Casting |
| Mary Sweeney | Editor |
| Patricia Norris | Production Design |
| Peter Deming | Director of Photography |
| Tom Sternberg | Producer |
| Mary Sweeney | Producer |
| Philip Bartko | Special Effects |
| Bruce Paul Barbour | Stunts |
| Deepak Nayar | Producer |
| David Lynch | Writer |
| Barry Gifford | Writer |
| David Grant | Dialogue Editor |
| Scott Andrew Ressler | First Assistant Camera |
| Angelo Badalamenti | Original Music Composer |
| Marilyn Graf | Foley Editor |
| David Mann | Foley Editor |
| Laura Laird | Foley Editor |
| Lucy Sustar | Foley Editor |
| Joshua E. Schneider | Foley Editor |
| Susan Shin | Dialogue Editor |
| Paul Longstaffe | Dialogue Editor |
| Louis Creveling | Dialogue Editor |
| Thomas Jones | Supervising Dialogue Editor |
| Craig Sherman Hall | Property Master |
| Robert Jauregui | Stunts |
| Hilary Schroeder | Assistant Editor |
| Rick Seaman | Stunts |
| Eric DaRe | Property Buyer |
| Cole S. McKay | Stunts |
| Jophery C. Brown | Stunts |
| Eliza Coleman | Stunts |
| Gilbert B. Combs | Stunts |
| Scott Cameron | First Assistant Director |
| Simone Farber | Second Assistant Director |
| Adam Rosen | Second Second Assistant Director |
| Patricia Miller | Hairstylist |
| Michael Burnett | Special Effects Makeup Artist |
| Hayley Cecile | Assistant Makeup Artist |
| Russell J. Smith | Art Direction |
| Patricia Norris | Costume Design |
| Marisa Aboitiz | Set Costumer |
| Chris Howell | Stunt Coordinator |
| Gene Hartline | Stunts |
| Joey Box | Stunts |
