 | Madonna als Self |
 | Erika Belle als Dancer (segment "Lucky Star") (segment "Papa Don't Preach") |
| Christopher Ciccone als Dancer (segment "Lucky Star") |
 | John Leguizamo als Friend of Boyfriend (segment "Borderline") |
| Louie Louie als Boyfriend (segment "Borderline") |
 | Deke Anderson als The Director (segment "Material Girl") |
 | Keith Carradine als Boyfriend (segment "Material Girl") |
| Sharon Oreck als Woman in clown costume (segment "Material Girl") |
 | Robert Wuhl als Pitch Man (segment "Material Girl") |
 | Danny Aiello als Papa (segment "Papa Don't Preach") |
 | Debi Mazar als Friend (segment "Papa Don't Preach") |
 | Alex McArthur als Boyfriend (segment "Papa Don't Preach") |
 | Mailon Rivera als Friend (segment "Papa Don't Preach") |
 | Felix Howard als Kid (segment "Open Your Heart") |
 | Benicio del Toro als Kid Sitting on Car (segment "La Isla Bonita") |
 | Leon als Innocent Man / Saint (segment "Like a Prayer") |
 | Cameron Alborzian als Man (segment "Express Yourself") |
 | Todd Gordon als Factory Worker (segment "Express Yourself") |
 | Gustav Vintas als Prison Wardon (segment "Express Yourself") |
 | Tony Ward als Merman (segment "Cherish") |
| Mark Romano als Father (segment "Oh Father") |
| Luis Camacho als Voguer (segment "Vogue") |
| Oliver Crumes Jr. als Voguer (segment "Vogue") |
 | Donna DeLory als Voguer (segment "Vogue") |
 | Salim Gauwloos als Voguer (segment "Vogue") |
| Jose Guitierez als Voguer (segment "Vogue") |
 | Niki Haris als Voguer (segment "Vogue") |
 | Kevin Stea als Voguer (segment "Vogue") |
| Gabriel Trupin als Voguer (segment "Vogue") |
 | Carlton Wilborn als Voguer (segment "Vogue") |
| Arthur Pierson | Director |
| Michele Ferrone | Director |
| Mary Lambert | Director |
| James Foley | Director |
| Jean-Baptiste Mondino | Director |
| David Fincher | Director |
| Herb Ritts | Director |
| Bruce Gowers | Director |
| Brian Elliot | Writer |
| James Foley | Writer |
| Madonna | Writer |
| Keith Williams | Writer |
| Madonna | Songs |
| Stephen Bray | Songs |
| Peter H. Brown | Songs |
| Gardner Cole | Songs |
| Brian Elliot | Songs |
| Bruce Gaitsch | Songs |
| Tom Kelly | Songs |
| Patrick Leonard | Songs |
| Reggie Lucas | Songs |
| Shep Pettibone | Songs |
| Peter Rafelson | Songs |
| Robert Rans | Songs |
| Billy Steinberg | Songs |
| Michael Ballhaus | Director of Photography |
| Jordan Cronenweth | Director of Photography |
| Andrea Dietrich | Director of Photography |
| Wayne Isham | Director of Photography |
| Pascal Lebègue | Director of Photography |
| Bryan Loftus | Director of Photography |
| Mark Plummer | Director of Photography |
| Steven Poster | Director of Photography |
| Herb Ritts | Director of Photography |
| Peter Sinclair | Director of Photography |
