 | Annette Bening als Diana Nyad |
 | Jodie Foster als Bonnie Stoll |
 | Rhys Ifans als John Bartlett |
 | Ethan Jones Romero als Nico |
 | Luke Cosgrove als Luke Tipple |
 | Jeena Yi als Angel Yanigahara |
 | Eric T. Miller als Coach Jack Nelson |
| Anne Marie Kempf als Candace |
 | Carolyn McCormick als Elise |
| Marcos Diaz als Dude |
| Belle Darling als Diana, Age 5 |
| Pearl Darling als Diana, Age 5 |
 | Johnny Solo als Aris |
| Anna Harriette Pittman als Diana, Age 14 |
| Hanler Rodriguez als Miguel |
| Harraka Eliana als Lucy |
| Marcella Acuña Báez als Suzanne |
| Sophia Hernandez als Opposing Girl |
 | Katherine Klosterman als Woman Swimmer |
 | Toussaint Merionne als Taxi Driver |
| Tisola Logan als Anna |
| Orpha Salimata als Mia |
 | Erica Cho als Naomi |
| Marina Vasarhelyi-Chin als St. Maarten Kid #1 |
| James Vasarhelyi-Chin als St. Maarten Kid #2 |
| Nadia Lorencz als Nadia |
 | Marcus Young als Diver |
 | Karly Rothenberg als Dee Brady |
 | Grace Subervi als Medic |
 | Stephen Schnetzer als Commentator |
 | Elizabeth Chahin als Reporter |
 | Garland Scott als Jon Rose |
| Iván Oleaga als Trainer |
 | Jose Mota Prestol als Fisherman James |
 | Melissa R. Stubbs als Female Cop |
| Mauricio Adrian als Paramedic (uncredited) |
 | Samantha Gordon als Katie (Register Girl) (uncredited) |
 | Lilo Grunwald als Nina (uncredited) |
 | Diana Nyad als Self (archive footage) |
| Bonnie Stoll als Self (archive footage) |
 | John F. Kennedy als Self (archive footage) |
| John Bartlett als Self (archive footage) |
 | Ellen DeGeneres als Self (archive footage) |
| Dee Brady als Self (archive footage) |
 | Kate McKinnon als Self (archive footage) |
| Elizabeth Chai Vasarhelyi | Director |
| Jimmy Chin | Director |
| Andrew Lazar | Producer |
| Teddy Schwarzman | Producer |
| Jamie Marshall | Co-Producer |
| Jim Seibel | Executive Producer |
| D. Scott Lumpkin | Executive Producer |
| Bill Johnson | Executive Producer |
| Michael Heimler | Executive Producer |
| Julia Cox | Executive Producer |
| Claudio Miranda | Director of Photography |
| Avy Kaufman | Casting |
| Kara Lindstrom | Production Design |
| María Fernanda Sabogal | Art Direction |
| Kelli Jones | Costume Design |
| Deborah Wallach | Supervising Sound Editor |
| Agueda Anaya Angulo | Third Assistant Director |
| Mauricio Coronado | Third Assistant Director |
| Amalia Ramírez Atiles | Second Assistant Director |
| Peter Zuccarini | Second Unit Director |
| Tom Fleischman | Sound Re-Recording Mixer |
| Marco Vargas Garcia | Utility Sound |
| Diana Nyad | Book |
| Vanessa Humphrey | Executive Producer |
| Mark Rayner | Second Unit Director |
| Melissa R. Stubbs | Stunt Double |
| Lauren Shaw | Stunt Double |
| Héctor Alfaro | Key Grip |
| Salim Bensrhir | Gaffer |
| Mateo Bourdieu | First Assistant "A" Camera |
| Rohan Chitrakar | Digital Imaging Technician |
| Josh Coffin | Underwater Camera |
| Daniel De La Cruz Corporán | Video Assist Operator |
| Alex C. Coyle | Loader |
| Melanie De Jesus | Best Boy Electric |
| Martín de Jesús | Gaffer |
| Gabriel De La Parra | Drone Operator |
| Miguel Batista El Chévere | Key Rigging Grip |
| Kiley Etter | Lighting Programmer |
| Kimberly French | Still Photographer |
| Sean P. Gilbert | Underwater Camera |
| Blake Hooks | Second Assistant "B" Camera |
| Luis Alfaro Imaz | Best Boy Electric |
| Dubin Kim | Best Boy Grip |
| BJ McDonnell | Steadicam Operator |
| Manny Emmanuel Medina | Assistant Camera |
| Javier Mejía | Grip |
| Kim Olsen | Key Grip |
| Jordan Pellegrini | Second Assistant "A" Camera |
| Francisco Javier Peña | Best Boy Grip |
| Robert Smathers | First Assistant "B" Camera |
| Juan Alberto Ureña | Grip |
| Peter Zuccarini | Underwater Director of Photography |
| Loretta Castellanos | Art Department Coordinator |
| Mariel Demorizi | Graphic Designer |
| Walter Jennings Fowler | Assistant Property Master |
| Alejandro Pérez Félix | Leadman |
| Braulio Gil | Set Decoration Buyer |
| Vera Gomez | Assistant Set Designer |
| Hector M. Gonzalez | Property Master |
| Ereminda Imbert | Construction Coordinator |
| Richard Poulain | Storyboard Artist |
| John Pundt | Graphic Designer |
| Ernesto Solo | Supervising Art Director |
| Milechka Sterlin | Set Designer |
| Trino Madriz | ADR Mixer |
| John Moros | Dialogue Editor |
| Bartek Swiatek | Production Sound Mixer |
| Marco Vargas Garcia | Sound |
| Fabricio Aquino | Special Effects Assistant |
| Radhames Bido | Special Effects Assistant |
| Diego Fabian Lozada Bocanegra | Special Effects |
| George A. Cabrera | Special Effects Assistant |
| Carlos Manuel Capellán | Special Effects Assistant |
| Nayiver Castaño | Special Effects Assistant |
| Jaime Castillo | Special Effects Supervisor |
| Prospero Felix | Special Effects Assistant |
| Jose Grassal | Special Effects Technician |
| Jeremy Hays | Special Effects Supervisor |
| Eliezer Llenas Sosa | Special Effects Technician |
| Fernando E. Medina | Special Effects Coordinator |
| Eury Rodriguez | Special Effects Technician |
| Miguel Basulto | Digital Compositor |
| Syed Arafath Apsar | Visual Effects Producer |
| Chris Watts | Visual Effects Supervisor |
| Katherine Klosterman | Stunt Double |
| Mark Rayner | Stunt Coordinator |
| Marcos Caraballo | Dailies Manager |
| Maria Elias | Dailies Operator |
| Jordan Farewell | Assistant Editor |
| Tom Klane | Colorist |
| Zachary A. Schwartz | First Assistant Editor |
| Julia Cox | Screenplay |
| Christopher Tellefsen | Editor |
| Luca Borghese | Co-Producer |
| Alexandre Desplat | Original Music Composer |
| Susan Jacobs | Music Supervisor |
| Jake Braver | Visual Effects Supervisor |
| D. Scott Lumpkin | Unit Production Manager |
| Jamie Marshall | First Assistant Director |
| Rafael Sanz | Second Assistant Director |
| Fiona Campbell Westgate | Associate Producer |
| Timothy Wheeler | Consulting Producer |
| Diz Sharpe | Stunt Coordinator |
| Matthew H. O'Connor | Stunts |
| Marcus Young | Stunts |
| Nadia Lorencz | Stunts |
| Ivan A. Reynoso | Production Manager |
| Carlos Rey del Castillo | Production Supervisor |
| Patricia Pachy Ramírez | Production Supervisor |
| David Rogow | First Assistant Editor |
| Courtney Marquard | Assistant Editor |
| David Alexander Smith | Visual Effects Editor |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Grant Elder | Sound Re-Recording Mixer |
| Julia Frey | Visual Effects Producer |
| David C. Sales | Visual Effects |
| Lauren Orban | Post Production Coordinator |
| Elizabeth Boller | Art Direction |
| Karla Feliz | Set Decoration |
| Sharlyn Navarro | Set Decorating Coordinator |
| Rolando Ozuna | Set Dresser |
| José Argenis Minyeti | Set Dresser |
| Rusbelt Sierra | Set Dresser |
| Julio César Collado | Set Dresser |
| Javier Coco | Set Dresser |
| Ronnie Fernandez | Set Dresser |
| Deulin Alexander Pineda | Swing |
| Juan Ramón Ortiz | Swing |
| José F. Lugo | Swing |
| Rafael Cuevas | Swing |
| Héctor Ramos | Assistant Property Master |
| Jean-Paul Chreky | Script Supervisor |
| BJ McDonnell | "B" Camera Operator |
| Kalli Kouf | Second Assistant "B" Camera |
| David Darwin | Lighting Programmer |
| Felix Rivera | Rigging Gaffer |
| Ramón Taylor | Rigging Gaffer |
| Yordani Mejía | Electrician |
| Juan Michael Peña | Electrician |
| Cristian Liriano | Electrician |
| Winsthon Junior de Jesús | Electrician |
| Stalin Perez | Electrician |
| Mariano Rosario | Electrician |
| Lenin Pérez | Electrician |
| Federico Méndez | Electrician |
| Eduard De Jesús | Electrician |
| Juan Evangelista Fernández | Electrician |
| Walther López | Electrician |
| Jack Cruikshank | Dolly Grip |
| Mike Dodd | Dolly Grip |
| Felix Danilo Valerio | Dolly Grip |
| Jherson Missahell Pierre | Grip |
| Edward Moreta | Grip |
| Victor Lecio Nuñez | Grip |
| Russell Reyes | Grip |
| Junior Sánchez | Grip |
| Eduardo Diaz | Grip |
| Melvin Luis Valdez | Grip |
| Nelson García | Grip |
| Carlos Manuel Encarnación | Grip |
| José Alberto Ramos | Grip |
| Kelvin Rubio | Grip |
| Joan Placencio | Grip |
| Freddy Batista | Grip |
| Gary Engels Aquino | Grip |
| Antonio Damian | Grip |
| Miguel Tapia | Grip |
| Pud Cusack | Production Sound Mixer |
| Alex Burstein | Boom Operator |
| Dia Donnelly | Utility Sound |
| Philip Hayman | Costume Supervisor |
| Alina Julia | Costume Supervisor |
| Molly Mitchell | Assistant Costume Designer |
| Hillary Vicente | Costumer |
| Lourdes Gandía | Costumer |
| Wilson Paulino | Costume Coordinator |
| Larissa Gautreaux | Key Costumer |
| Cindy Ramirez | Key Set Costumer |
| Fanny Almonte | Costumer |
| Joel Cruz | Costumer |
| Palma Ruiz | Set Costumer |
| Daniel Aldana | Costumer |
| Caroll Maura | Ager/Dyer |
| Felicity Bowring | Makeup Department Head |
| Ann-Maree Hurley | Key Makeup Artist |
| Julie Hewett | Makeup Artist |
| Maha | Makeup Artist |
| Ana María Andrickson | Makeup Artist |
| Shantalle Hungría | Makeup Artist |
| Leo Corey Castellano | Special Effects Makeup Artist |
| Daniel Curet | Hair Department Head |
| Vanessa Colombo | Key Hair Stylist |
| Jandeira Avirón | Hairstylist |
| Lisbeth Aybar | Hairstylist |
| Tim Patterson | Production Coordinator |
| Natacha Rojas | Production Coordinator |
| Joe Colavincenzo | Assistant Production Coordinator |
| Linette Reynoso | Assistant Production Coordinator |
| Darinel Matos | Production Secretary |
| Alex Skrepnik | Production Accountant |
| Tracy Ellis | First Assistant Accountant |
| Danny Maze | Location Manager |
| Boni Canto | Location Manager |
| Gonzo Rey Del Castillo | Location Manager |
| Harold Castillo | Location Manager |
| Joan Vidal | Location Manager |
| José Pimentel | Location Manager |
| Emmanuel 'Poyo' Alcántara | Location Coordinator |
| Vicmayri Pérez | Assistant Location Manager |
| Jose Andres Roman | Assistant Location Manager |
| Reinaldo Fernández | Assistant Location Manager |
| Diego Rossi | Assistant Location Manager |
| Miguel Llorca | Construction Manager |
| Paula Jiménez Gonell | Construction Buyer |
| Manuel Fernández | Construction Foreman |
| Hemeregildo García | Carpenter |
| Paco Fernández | Carpenter |
| Candito Castro | Carpenter |
| Yomerki Parra | Carpenter |
| Franklin Pérez | Carpenter |
| Jonathan Rivas | Special Effects |
| Albeiro Villa | Special Effects Technician |
| Frank Hernández | Special Effects Technician |
| Horacio Valoy | Special Effects Assistant |
| Jeison Hernández | Special Effects Assistant |
| Enrique Granados | Transportation Coordinator |
| Brigitte Whitmire | Casting Associate |
| Nathan Francis | Casting Assistant |
| Oscar Manero | Second Second Assistant Director |
| Alejandro Durán | Third Assistant Director |
| Jana Ivanova Grozeva | Third Assistant Director |
| Eric Nieves | Post Production Assistant |
| Molly Gandour | Visual Effects Assistant Editor |
| Christopher Stack | Visual Effects Coordinator |
| Fay Gartenberg | Assistant Editor |
| Ric Schnupp | Sound Re-Recording Mixer |
| Grant Elder | Sound Designer |
| Eric Stapleton | Assistant Sound Editor |
| Roni Pillischer | Foley Editor |
| James Williams | Foley Editor |
| Leslie Bloome | Foley Artist |
| Shaun Brennan | Foley Artist |
| Curtis Henderson | Foley Artist |
| Ryan Collison | Foley Mixer |
| Connor Nagy | Foley Mixer |
| Bobby Johanson | ADR Mixer |
| Beau Emory | ADR Engineer |
| Lila Walsh | ADR Coordinator |
| Tricia Schultz | ADR Supervisor |
| Krissopher Chevannes | ADR Mixer |
| Raina Cagiao | ADR Coordinator |
| Jim Schultz | Supervising Music Editor |
| Kira Belin | Music Editor |
| Dominique Lemonnier | Music Score Producer |
| Stan Neff | Scoring Mixer |
