 | Emily Blunt als Liza Drake |
 | Chris Evans als Pete Brenner |
 | Catherine O'Hara als Jackie |
 | Jay Duplass als Larkin |
 | Andy García als Dr. Neel |
 | Brian d'Arcy James als Dr. Lydell |
 | Chloe Coleman als Phoebe |
 | Amit Shah als Eric Paley |
 | Aubrey Dollar als Andy |
 | Willie Raysor als Matt Elliston |
 | Britt Rentschler als Camille Trask |
 | Selena Anduze als Kate Elliston |
 | Nicholas Christopher McNeil als Randy |
 | Sharon Conley als Judge Susan Holman |
 | Michael Kosta als Guy Schatz |
 | Valerie LeBlanc als Laurene |
 | Adrian Eppley als Heather |
 | Josh Ventura als Dr. Jimmy |
 | Michael Lowry als Dan Watt |
 | Greyson Chadwick als Maria |
 | Alex Klein als Sidney Trask |
 | Erin Ownbey als Young Jackie |
 | Mandi Christine Kerr als Clinic RN |
| Alexis Baca als Pharmaceutical model |
 | Pat Dortch als Nervous Doctor |
 | Elle Lisic als Daughter #2 |
| Mary Ann Hagan als Patient #1 |
 | Tris Marie als Lydell Nurse |
| Quinn Bozza als Paul |
 | Shelley Jane als Nervous Doctor's Crush |
 | Avis-Marie Barnes als Principal |
 | Omer Mughal als Agent Simonetti |
| Tristan Shufford als Matt's Son #1 |
| Chris Marks als Jeff |
| Bella Winkowski als Luna |
| Samantha Kacho als Catherine |
| Jackson Abram als Matt's Son #2 |
 | A.K. Benninghofen als Dr. Bowen |
| Abigail Susan Williams als Lindsay |
| Becca Breitfeller als Applicant #2 |
| Rebecca Barnes als Office Staffer |
| Trace Haynes als Customer (uncredited) |
| Rowan Joseph als Podiatrist #2 (uncredited) |
 | Chinet Scott als Nicole |
 | Hannah Pniewski als Surgical Nurse |
| David Yates | Director |
| Wells Tower | Writer |
| Lawrence Grey | Producer |
| Lewis Taylor | Executive Producer |
| Ben Everard | Executive Producer |
| Cyrus Mojibi | Co-Producer |
| Patrick Wade | Co-Producer |
| Lloyd Everard | Co-Producer |
| Cliff Lanning | Co-Producer |
| Molly Hughes | Production Design |
| Kim Leoleis | Set Decoration |
| Bridget Keefe | Assistant Set Decoration |
| Cliff Lanning | First Assistant Director |
| Dixon McPhillips | Second Assistant Director |
| Adam Horwitz | Stunt Double |
| Taryn Terrell | Stunts |
| Todd Warren | Stunt Coordinator |
| Tricia Yoo | Costumer |
| Dodd Vickers | Location Scout |
| Michael Dzenowagis | Special Effects |
| Eric Kaufman | Special Effects Supervisor |
| Marc Casey | Underwater Camera |
| Brian Douglas | Still Photographer |
| Daniel A Hernandez | Digital Imaging Technician |
| Erik D. Magnus | Production Sound Mixer |
| Glenn Freemantle | Supervising Sound Editor |
| Patrick Fuhrman | Leadman |
| Michael Glynn | Property Master |
| Aaron Robert Hall | On Set Dresser |
| Candace Rochelle Lee | Art Department Coordinator |
| Christopher McGee | Set Designer |
| John Greg Moncrief | Scenic Artist |
| Steven M. Saylor | Set Designer |
| James Bryant Wactor | Construction Foreman |
| Nina A. White | Set Dresser |
| Stan J. White | Set Dresser |
| Donald Reynolds Jr. | Production Supervisor |
| Ash Anderson | Other |
| London Bicknell | Tailor |
| Ashley Marie Parker | Set Costumer |
| Sara Alread | Assistant Location Manager |
| Oliver Pearce | Assistant Location Manager |
| Jessica Lichtner | Script Supervisor |
| Annie Thompson | Additional Script Supervisor |
| George Richmond | Director of Photography |
| Mark Day | Editor |
| Fiona Weir | Casting Director |
| Hannah Hildebrandt | Assistant Art Director |
| Haven J. Kim | Assistant Art Director |
| Dennis Bailey | Key Hair Stylist |
| Mandy Bisesti | Key Makeup Artist |
| Erin Chaney | Makeup Artist |
| Heather Grippaldi | Makeup Artist |
| Lauren Killip | Key Makeup Artist |
| Courtney Mark | Makeup Artist |
| Tana Medina | Makeup Artist |
| Evelyne Noraz | Makeup Department Head |
| Rondi Scott | Makeup Artist |
| Tammi Terrell | Hairstylist |
| Kaylee Alvarez | Set Designer |
| David Yates | Producer |
| James Newton Howard | Original Music Composer |
| Lauren Shaw | Stunt Double |
| Meagan Marie Kautz | Stunt Double |
| Shawn Kautz | Stunt Coordinator |
| David Turner | Stunt Driver |
| Samantha Parisi | Stunt Driver |
| Jared Corum | Stunt Driver |
| Lawrence Kao | Co-Producer |
| Evan Hughes | Book |
| Emily Blunt | Executive Producer |
| Mark Moran | Executive Producer |
| Yvonne Walcott-Yates | Executive Producer |
| Colleen Atwood | Costume Design |
| Michael Dean Parsons | Original Music Composer |
