 | Drew Barrymore als Beverly Donofrio |
 | Steve Zahn als Ray Hasek |
 | Adam Garcia als Jason |
 | Brittany Murphy als Fay Forrester |
 | James Woods als Leonard Donofrio |
 | Lorraine Bracco als Teresa Donofrio |
 | Rosie Perez als Shirley Perro |
 | Sara Gilbert als Tina Barr |
 | Peter Facinelli als Tommy Butcher |
 | Mika Boorem als Beverly Donofrio (Age 11) |
 | Vincent Pastore als Uncle Lou |
 | Maryann Urbano als Aunt Ann |
 | Alexia Landeau als Jenny |
 | Kristin Proctor als Cindy |
 | Celine Ordioni als Janet Donofrio (Age 8) |
| Alissa Dean als Townie Girl #1 |
| Jessica Leshnower als Townie Girl #2 |
| Temple Brooks als Karen |
| Lauren Lake als Karen's Friend |
 | Desmond Harrington als Bobby |
 | Jordan Gelber als Kevin |
| Gabriel Carpenter als Sky Barrister |
 | Kevin Thoms als Mark |
 | Vincent De Paul als Linebacker |
| Joseph Cassese als Linebacker |
 | Kevin O'Rourke als Jail Ward |
 | Susan Forristal als Mrs. Forrester |
 | John Bedford Lloyd als Mr. Forrester |
 | Paz de la Huerta als Phone Call Flirt |
| Olivia Morgan Scheck als Janet Donofrio (Age 12) |
 | David Moscow als Lizard |
| Dusty Rizzo als Wedding Singer Tony |
 | Gene Canfield als Pete |
 | Carl Capotorto als Cop #1 |
 | Robert Greenhut als Cop #2 |
| Heather Hodder als Donofrio Cousin |
| Sean Liotine als Zippy |
 | Tracy Reiner als Nurse |
| Joseph M. Cannizaro als Jason (Newborn) |
| Noah Hartwick als Jason (Newborn) |
| Briana Tilden als Jason (Baby) |
 | Skye Arens als Jason (Age 1) |
| Patrick Salerno als Jason (Age 2) |
| Robert Salerno als Jason (Age 2) |
| Logan Arens als Jason (Age 3) |
| Samantha Reale als Amelia (Age 3) |
 | Wade Mylius als Al |
| Jon Korkes als Counselor |
| Cody Arens als Jason (Age 6) |
| Samantha Lucier als Amelia (Age 6) |
| Gaetano Lisi als Sweeny's Owner |
 | Marisa Ryan als Janet Donofrio (Age 19) |
 | Maggie Gyllenhaal als Amelia |
 | Logan Lerman als Jason (Age 8) |
 | Skye McCole Bartusiak als Amelia (Age 8) |
 | Michael Linstroth als Dennis Forrester |
| Sophia Barricelli als Sophia (uncredited) |
| Shani Bayne Haller als Waitress (uncredited) |
| J.D. Brookshire als Jerk in Car (uncredited) |
| Jeff Buckner als Party Guest (uncredited) |
 | Toni D'Antonio als Tied-Dyed Girl (uncredited) |
| Anna Damergis als Cop's Wife (uncredited) |
 | Gene Gabriel als Make-Out Guy (uncredited) |
 | Jaime Gallagher als Car Passenger (uncredited) |
 | Donna Sue Jahier als Woman in Maternity Ward (uncredited) |
| Rich Keen als Passer By in Car (uncredited) |
 | Richard Keith als Heald Family Member (uncredited) |
| Sara Klingebiel als Townie Girl #3 (uncredited) |
| Randi Rosenholtz als Townie Girl #4 (uncredited) |
| Peter Austin Noto als Short Order Cook (uncredited) |
| Dana Segal als Hippie Neighbor (uncredited) |
| Mario Simone als Student (uncredited) |
| Marilyn Spanier als Mary (uncredited) |
 | Todd Wall als Nice Guy at Party (uncredited) |
 | Bill Walters als Hippie at Party (uncredited) |
| Morgan Ward | Screenplay |
| Lawrence Jordan | Editor |
| Hans Zimmer | Original Music Composer |
| Penny Marshall | Director |
| Miroslav Ondříček | Director of Photography |
| Julie Ansell | Producer |
| Richard Sakai | Producer |
| Marion Kolsby | Assistant Art Director |
| John M. Chalfant | Sound Effects Editor |
| Terel Gibson | Assistant Editor |
| Juli Vizza | Assistant Editor |
| Richard Marks | Editor |
| Don Kozma | Makeup Artist |
| Richard Corwin | Dialogue Editor |
| Alison Fisher | ADR Supervisor |
| Keith Bunting | Dolly Grip |
| Kathleen Corgan | Camera Loader |
| Gary Muller | First Assistant Camera |
| Lane Burch | Foley Mixer |
| Galen Goodpaster | Assistant Sound Editor |
| Carin Rogers | Dialogue Editor |
| Alicia Stevenson | Foley Artist |
| Joe Collins | First Assistant Camera |
| Xavier Henselmann | Assistant Chief Lighting Technician |
| Doug Cluff | Scenic Artist |
| Sylvia Trapanese | Scenic Artist |
| Laura Graham | ADR Editor |
| Craig DiBona | Camera Operator |
| George DeTitta Jr. | Set Decoration |
| Stanley Hall | Hairstylist |
| Stewart Nelsen | Sound Effects Editor |
| Amy Leigh Johnson | Unit Publicist |
| Beverly D'Onofrio | Co-Producer |
| Sheila Jaffe | Casting |
| Christine Leiter | Makeup Artist |
| Wayne Griffin | ADR Editor |
| Matthew W. Flannery | Second Assistant "B" Camera |
| A. Lee Morris | Second Assistant Camera |
| Paul Parsons | Assistant Editor |
| Jennifer Nash | Music Editor |
| Laurence Mark | Producer |
| Bridget Johnson | Executive Producer |
| Francesca Paris | Key Hair Stylist |
| Raymond M. Samitz | Construction Coordinator |
| David A. Arnold | Dialogue Editor |
| Kira Edmunds | Assistant Sound Editor |
| Petr Hlinomaz | Chief Lighting Technician |
| Laura Perlman | Music Editor |
| Scott Kordish | Production Coordinator |
| Bernadette Mazur | Key Makeup Artist |
| Richard Patrick | First Assistant Director |
| Garf Brown | Scenic Artist |
| Stephen H. Carter | Assistant Art Director |
| Matthew Dettmann | Foley Editor |
| Joe White | Boom Operator |
| Verna Mandel | Music Editor |
| Danielle Rigby | Second Assistant Director |
| Ted Haigh | Assistant Art Director |
| Amy Safhay | Greensman |
| Billy Patsos | Rigging Grip |
| James L. Brooks | Producer |
| Cynthia Flynt | Costume Design |
| David Betancourt | Foley Mixer |
| Jeffrey J. Haboush | Sound Re-Recording Mixer |
| Michael O'Farrell | Sound Effects Editor |
| Lynn Hoffman | Assistant Costume Designer |
| Cheryl Kilbourne-Kimpton | Wardrobe Supervisor |
| Kathleen Mobley | Wardrobe Coordinator |
| Debra L. Tennant | First Assistant Editor |
| Luca Kouimelis | Script Supervisor |
| Al Cerullo | Pilot |
| Molly Mikula | Assistant Art Director |
| Christine Danelski | Foley Editor |
| Joni M. Huth | Seamstress |
| Lyn Pinezich | Location Manager |
| Beverly D'Onofrio | Book |
| Georgianne Walken | Casting |
| Kyle Rudolph | Steadicam Operator |
| Rose Wells | Wardrobe Supervisor |
| Greg Thompson | Assistant Editor |
| Bill Groom | Production Design |
| Judi Goodman | Hairstylist |
| Bill W. Benton | Sound Re-Recording Mixer |
| Ann Ducommun | Assistant Sound Editor |
| Dawn Fintor | Foley Artist |
| Howard London | ADR Mixer |
| Michele Perrone | ADR Editor |
| Sara Colleton | Producer |
| Morgan Ward | Executive Producer |
| Teresa Carriker-Thayer | Art Direction |
| Bill Burns | Assistant Sound Editor |
| Victoria Rose Sampson | Dialogue Editor |
| Marisa Morabito | Assistant Editor |
| Kimberly Greene | Makeup Artist |
| Barbara Olvera | Hairstylist |
| Richard Baratta | Unit Production Manager |
| Gerald DeTitta | Leadman |
| Gloria D'Alessandro | Dialogue Editor |
| Dana LeBlanc Frankley | Assistant Sound Editor |
| Scott G.G. Haller | Foley Editor |
| George Patsos | Key Grip |
| Andrew D. Schwartz | Still Photographer |
| John Sosenko | Camera Operator |
| Katharina Eggmann | Casting Associate |
| David H. Allen | Property Master |
| Dennis Drummond | Supervising Sound Editor |
| Kim Drummond | Dialogue Editor |
| Gary A. Hecker | Foley Artist |
| Jonathan Klein | Foley Supervisor |
| Gary Archer | Prosthetics |
| Amy Lemisch | Co-Producer |
| Timothy M. Bourne | Co-Producer |
| Heitor Pereira | Additional Soundtrack |
