 | Tobin Bell als John Kramer / Jigsaw |
 | Costas Mandylor als Mark Hoffman |
 | Scott Patterson als Agent Strahm |
 | Betsy Russell als Jill Tuck |
 | Julie Benz als Brit |
 | Meagan Good als Luba |
 | Mark Rolston als Dan Erickson |
 | Carlo Rota als Charles |
 | Greg Bryk als Mallick |
 | Laura Gordon als Ashley |
 | Joris Jarsky als Seth |
 | Mike Butters als Paul |
 | Al Sapienza als Chief of Police |
 | Mike Realba als Detective Fisk |
 | Jeff Pustil als Bernie |
| Dana Sorman als Law Office Receptionist |
 | Sheila Shah als Special Agent Cowan |
 | Samantha Lemole als Pamela Jenkins |
 | Niamh Wilson als Corbett Denlon |
 | Lisa Berry als EMT |
| Bill Vibert als Officer |
 | Tony Nappo als Gus |
 | Brandon McGibbon als Hank |
 | Timothy Burd als Obi |
 | Natalie Brown als Heather Miller |
| Quancetia Hamilton als Person with Dog |
| Lorraine Foreman als Old Woman |
 | Sarah Power als Angelina |
 | Cory Lee als Jasmine (scenes deleted) |
| David Gale als Additional Voice Talent (voice) |
| Catherine Rix als Additional Voice Talent (voice) |
 | Michael A. Miranda als Additional Voice Talent (voice) |
| Stephen Sparks als Additional Voice Talent (voice) |
| Jennifer Donison als Additional Voice Talent (voice) |
| Wayne Curnew als Bartender (uncredited) |
| Alex Revan als Grayson Blood (uncredited) |
| David Hackl | Director |
| Oren Koules | Producer |
| Alex Kavanagh | Costume Design |
| Mark Burg | Producer |
| Anthony Ianni | Production Design |
| Liesl Deslauriers | Set Decoration |
| Gregg Hoffman | Producer |
| Stephanie Gorin | Casting |
| Elis Y. Lam | Art Direction |
| David A. Armstrong | Director of Photography |
| Alan Letts | Construction Coordinator |
| Monty Montgomerie | Key Grip |
| Trevor Lewis | Digital Intermediate |
| Stephanie Ingram | Key Hair Stylist |
| Kym Crepin | Production Manager |
| Steve Baine | Foley |
| Steve Wilkie | Still Photographer |
| Jonathan Platt | Music Supervisor |
| Nick Paulozza | Digital Intermediate |
| James R. Murray | Property Master |
| Clive Turner | Sound Effects Editor |
| Kemal Ally | 3D Animator |
| Brian Gedge | Steadicam Operator |
| Jon Campfens | Visual Effects Supervisor |
| Craig-Ryan French | Makeup Artist |
| Steve Webb | First Assistant Director |
| Tim Lovell | Rigging Gaffer |
| Andrew Tay | Sound Re-Recording Mixer |
| Doug Reid | Best Boy Electrician |
| Stephanie Lees | Assistant Costume Designer |
| Tom Mayclim | Digital Intermediate |
| Kevin Greutert | Editor |
| Keith Elliott | Sound Re-Recording Mixer |
| David Alexander | 3D Animator |
| Peter Armstrong | Digital Intermediate |
| Jonathan McHugh | Music Supervisor |
| Colin Penman | Key Makeup Artist |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| Gary Brown | Digital Intermediate |
| Pat Cassin | Boom Operator |
| Geoff Raffan | Dialogue Editor |
| Jeff Skochko | Special Effects Supervisor |
| Thomas Care | Dolly Grip |
| Robert McRae | Gaffer |
| Rob Bertola | Music Editor |
| Mark Gingras | Supervising Sound Editor |
| Edward Lipscombe | Rigging Grip |
| Motassem Younes | Digital Intermediate |
| Elizabeth Tremblay | Script Supervisor |
| John Douglas Smith | Supervising Sound Editor |
| Peter Denomme | Visual Effects Producer |
| Jonathan Scott Miller | Music Supervisor |
| Chris Wallace | Digital Intermediate |
| Peter Block | Executive Producer |
| Marcus Dunstan | Screenplay |
| Sarah Buell | Second Assistant Director |
| Patrick Melton | Screenplay |
| Troy Begnaud | Associate Producer |
| James Wan | Executive Producer |
| Leigh Whannell | Executive Producer |
| Jason Constantine | Executive Producer |
| Daniel J. Heffner | Executive Producer |
| Stacey Testro | Executive Producer |
| Charlie Clouser | Original Music Composer |
| Jane Rogers | Background Casting Director |
| Billy Oliver | Stunt Double |
| Duncan McLeod | Stunt Double |
| Dwayne McLean | Stunt Double |
| Blair Johannes | Stunt Double |
| Susan Horton | Stunt Double |
| Shelley Cook | Stunt Coordinator |
| Chad Camilleri | Stunt Double |
| Chad Camilleri | Stunts |
| Leigh Whannell | Original Film Writer |
| James Wan | Original Film Writer |
