 | Tobin Bell als John Kramer / Jigsaw |
 | Costas Mandylor als Mark Hoffman |
 | Mark Rolston als Dan Erickson |
 | Betsy Russell als Jill Tuck |
 | Shawnee Smith als Amanda Young |
 | Peter Outerbridge als William |
 | Athena Karkanis als Agent Perez |
 | Samantha Lemole als Pamela Jenkins |
 | Tanedra Howard als Simone |
 | Marty Moreau als Eddie |
 | Shawn Ahmed als Allen |
 | Janelle Hutchison als Addy |
 | Gerry Mendicino als Janitor |
 | Caroline Cave als Debbie |
 | George Newbern als Harold |
 | Shauna MacDonald als Tara |
 | Devon Bostick als Brent |
 | Darius McCrary als Dave |
 | Shawn Mathieson als Josh |
 | Melanie Scrofano als Gena |
 | Karen Cliche als Shelby |
 | James Gilbert als Aaron |
 | Larissa Gomes als Emily |
 | Dan Duran als Newscaster |
 | Billy Otis als Cecil |
 | James Van Patten als Coroner |
 | Jon Mack als Female Addict |
 | François Sagat als Male Addict |
 | Elle Downs als Clinic Nurse |
 | Tenika Davis als Irate Clinic Woman |
 | Karl Campbell als Security Guard |
| Ginger Ruriko Busch als Sachi |
 | Jessie Rusu als Female Officer |
 | Mpho Koaho als Tim |
 | Chris Owens als Additional Voice Talent |
 | Vickie Papavs als Additional Voice Talent |
| Catherine Rix als Additional Voice Talent |
| John Watson als Additional Voice Talent |
 | Joris Jarsky als Seth (uncredited) |
 | Angus Macfadyen als Jeff Denlon (uncredited) |
 | Scott Patterson als Agent Strahm (uncredited) |
 | Bahar Soomekh als Lynn Denlon (uncredited) |
 | Niamh Wilson als Corbett Denlon (uncredited) |
| Kevin Greutert | Director |
| Gregg Hoffman | Producer |
| Alex Kavanagh | Costume Design |
| Anthony Ianni | Production Design |
| Oren Koules | Producer |
| Elis Y. Lam | Art Direction |
| Stephanie Gorin | Casting |
| Mark Burg | Producer |
| Dale Lennon | Dialogue Editor |
| Angel Gonzalez | Camera Operator |
| Stephanie Ingram | Key Hair Stylist |
| Clive Turner | Sound Effects Editor |
| Robert McRae | Gaffer |
| Doug Reid | Best Boy Electric |
| Gary Bower | Dolly Grip |
| Andrew Coutts | Editor |
| Tom Bjelic | Sound Designer |
| Rob Sanderson | Special Effects Supervisor |
| Jon Campfens | Visual Effects Supervisor |
| Tony Guerin | Camera Operator |
| Jonathan Scott Miller | Music Supervisor |
| Tim Lovell | Rigging Gaffer |
| Mongo Andrews | Rigging Grip |
| Patrick King | Dolly Grip |
| Monty Montgomerie | Key Grip |
| Motassem Younes | Digital Intermediate |
| Mark Gingras | Supervising Sound Editor |
| Ciara Brennan | Assistant Costume Designer |
| Keith Elliott | Sound Re-Recording Mixer |
| Allan Fung | Supervising Sound Editor |
| Jonathan McHugh | Music Supervisor |
| David A. Armstrong | Director of Photography |
| Steve Webb | First Assistant Director |
| Sean Paul Armstrong | Boom Operator |
| Nigel Draper | Electrician |
| Trevor Pickard | Digital Intermediate |
| Liesl Deslauriers | Set Decoration |
| Colin Penman | Key Makeup Artist |
| François Dagenais | Prosthetic Designer |
| Andrew Tay | Sound Re-Recording Mixer |
| Steve Wilkie | Still Photographer |
| Beau Parsons | Visual Effects Coordinator |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| John Laing | Supervising Sound Editor |
| Steve Ferrier | Electrician |
| Jonathan Platt | Music Supervisor |
| Peter Armstrong | Digital Intermediate |
| Alan Letts | Construction Coordinator |
| Steve Baine | Foley |
| Peter Denomme | Visual Effects Producer |
| Brian Gedge | Steadicam Operator |
| Kym Crepin | Production Manager |
| James R. Murray | Property Master |
| Gary Brown | Digital Intermediate |
| Tom Mayclim | Digital Intermediate |
| Paul Intson | Music Editor |
| Elizabeth Tremblay | Script Supervisor |
| Lee Hughes | Digital Intermediate |
| Robert Doyle | First Assistant Editor |
| Peter Block | Executive Producer |
| Leigh Whannell | Executive Producer |
| Daniel J. Heffner | Executive Producer |
| Kaleigh Kavanagh | Associate Producer |
| Stacey Testro | Executive Producer |
| Marcus Dunstan | Screenplay |
| James Wan | Executive Producer |
| Jason Constantine | Executive Producer |
| Patrick Melton | Screenplay |
| Troy Begnaud | Co-Producer |
| Charlie Clouser | Original Music Composer |
| Shelley Cook | Stunt Coordinator |
| Sarah Buell | Second Assistant Director |
| Blair Johannes | Stunt Double |
| Joe Lalogga | Stunt Double |
| Joanne Leach | Stunt Double |
| Duncan McLeod | Stunt Double |
| Billy Oliver | Stunt Double |
| Efosa Otuomagie | Stunt Double |
| Allissa Ourakova | Stunt Double |
| Sue Parker | Stunt Double |
| Steven Ciancamerla | Set Dresser |
| Cherie Spencer | Set Dresser |
| Erika Schengili-Roberts | Production Sound Mixer |
| James Wan | Original Film Writer |
| Leigh Whannell | Original Film Writer |
