 | Jonathan Pryce als Sherlock Holmes |
 | Bill Paterson als Dr Watson |
 | Anna Chancellor als Irene Adler |
 | Michael Maloney als Inspector Stirling |
 | Aaron Taylor-Johnson als Finch |
 | Patrick Gibson als Laundry Boy |
 | Rory Nolan als Guard at the Mint |
 | Frank Murray als Mallory |
 | Chris McHallem als Footman |
 | Jack Walsh als French Chef |
| Julian Kemp | Director |
| Arthur Conan Doyle | Characters |
| Suzanne Smith | Casting |
| Niamh Buckley | Assistant Costume Designer |
| Leonie Prendergast | Costume Design |
| Andrew Rowley | Producer |
| Karen Rigg | Assistant Costume Designer |
| Caitriona Ní Threasaigh | Assistant Costume Designer |
| Bev Doyle | Writer |
| Richard Kurti | Writer |
| Debbie Wiseman | Music |
| Ciarán Tanham | Director of Photography |
| Tony Noble | Art Direction |
| Suzanne Keogh | Assistant Costume Designer |
| Liz Treacy | Costume Supervisor |
| Grant Hicks | Production Design |
| Ray Roantree | Editor |
| Andrew Lowe | Executive Producer |
| Rory Bruen | Assistant Art Director |
