 | Aaron Eckhart als Nick Naylor |
 | Maria Bello als Polly Bailey |
 | Cameron Bright als Joey Naylor |
 | Adam Brody als Jack |
 | Sam Elliott als Lorne Lutch |
 | Katie Holmes als Heather Holloway |
 | Rob Lowe als Jeff Megall |
 | William H. Macy als Senator Ortolan Finistirre |
 | Robert Duvall als The Captain |
 | David Koechner als Bobby Jay Bliss |
 | J.K. Simmons als BR |
 | Kim Dickens als Jill Naylor |
 | Connie Ray als Pearl |
 | Joan Lunden als Joan Lunden |
 | Mary Jo Smith als Sue Maclean |
 | Todd Louiso als Ron Goode |
 | Jeff Witzke als Kidnapper |
 | Marianne Muellerleile als Teacher |
 | Jordan Garrett als Kid #2 |
 | Courtney Taylor Burness als Kid #3 |
 | Daniel Travis als Brad |
 | Richard Speight Jr. als Trainee |
| Renée Graham als Tiffany |
 | Timothy Dowling als EGO Assistant |
 | Dennis Miller als Dennis Miller |
| Terry James als Ski Mask #1 |
 | Marc Scizak als Ski Mask #2 |
| Rachel Thorp als Flighty Girl |
 | Aaron Lustig als Doctor |
 | Melora Hardin als Interviewer |
 | Brian Palermo als FBI Agent (voice) |
 | Michael Mantell als Dr. Meisenbach |
 | Spencer Garrett als Senator Lothridge |
 | Earl Billings als Senator Dupree |
 | Catherine Reitman als Reporter #1 |
 | Sean Patrick Murphy als Reporter #2 |
 | David O. Sacks als Oil Lobbyist |
 | Nancy O'Dell als Nancy Humphries O'Dell |
 | Roy Jenkins als Debate Moderator |
 | Bruce French als Gentleman #2 |
| Christopher Buckley als Man at Metro Station (uncredited) |
 | Dana E. Glauberman als Hotel Phone Operator (voice) (uncredited) |
 | Eva La Dare als Flight Attendant (uncredited) |
| Robert Malina als Peter (uncredited) |
 | Aloma Wright als Gizelle (voice) (uncredited) |
 | Elon Musk als Valet (uncredited) |
| Alessandro Camon | Executive Producer |
| James Whitaker | Director of Photography |
| Christopher Buckley | Novel |
| Max Levchin | Executive Producer |
| David O. Sacks | Producer |
| Jason Reitman | Screenplay |
| John Schmidt | Executive Producer |
| Edward R. Pressman | Executive Producer |
| Dana E. Glauberman | Editor |
| Elon Musk | Executive Producer |
| Jason Reitman | Director |
| Michael Beugg | Executive Producer |
| Rolfe Kent | Original Music Composer |
| Peter Thiel | Executive Producer |
| Mark Woolway | Executive Producer |
| Bob Dohrmann | Production Supervisor |
| Marsha Lewis | Hair Department Head |
| Steve Saklad | Production Design |
| Carl Catanese | Leadman |
| Mindy Marin | Co-Producer |
| Kurt Meisenbach | Set Decoration |
| David Bloomfield | Co-Executive Producer |
| John E. Jackson | Makeup Department Head |
| Robin L. Neal | Makeup Artist |
| Mindy Marin | Casting |
| Joe Fineman | Post Production Supervisor |
| Danny Glicker | Costume Design |
| Michael Toji | Post Production Supervisor |
| Daniel Dubiecki | Co-Producer |
| Sherri Bramlett | Key Hair Stylist |
| Elisabeth Fry | Makeup Artist |
| Michael Beugg | Unit Production Manager |
| Stephen Belafonte | Associate Producer |
| Casey B. Garrett | Propmaker |
| Theresa Greene | Art Department Coordinator |
| Larry Fioritto | Special Effects Coordinator |
| Steven Samanen | Assistant Art Director |
| Kara Lipson | Casting Associate |
| Nick South | Music Editor |
| Greg Townley | Scoring Mixer |
| Margaret Yen | Music Supervisor |
| Julie Stevens | Studio Teachers |
| Brad Bryan | Cableman |
| Alex E. Burns | Driver |
| Mary Anne Seward | Script Supervisor |
| David Presley | Camera Operator |
| Ember Truesdell | Casting Associate |
| John Latenser V | Location Manager |
| Christopher Miller | Location Manager |
| Adam Jenkins | Sound Re-Recording Mixer |
| Scott Sanders | Sound Re-Recording Mixer |
| Craig Dollinger | Boom Operator |
| Josh Bower | Boom Operator |
| J. Armin Garza II | Driver |
| Damiano Fusca | Craft Service |
| Kevin Zimmerman | First Assistant Sound Editor |
| Terry James | Stunt Coordinator |
| Jack Lewars | Digital Intermediate |
| Daniel Nichols | Camera Operator |
| Mateo Messina | Additional Music |
| William Smallwood | Driver |
| Errol Reichow | Location Scout |
| J. Stanley Johnston | Sound Re-Recording Mixer |
| Perry Robertson | Supervising Sound Editor |
| Peter Afterman | Music Supervisor |
| Marco S. Paolini | Digital Compositors |
| Marc Scizak | Stunts |
| Joe Guzman | Grip |
| David Falicki | Set Medic |
| Lee Shapira | Grip |
| Stephen R. Sheridan | Color Timer |
| Traceigh Scottel | Production Coordinator |
| Dale Robinette | Still Photographer |
| Richard Dwan Jr. | Sound Editor |
| Gavin J. Behrman | Production Accountant |
| Robert Malina | Visual Effects Editor |
| Stephen M. Rickert Jr. | Assistant Editor |
| Neil Chisholm | Driver |
| Tim Gillis | Electrician |
| Melissa Sherwood Hofmann | Sound Re-Recording Mixer |
| Cosmas Paul Bolger Jr. | Visual Effects Producer |
| Tommy Lohmann | Steadicam Operator |
| Robert Malina | First Assistant Editor |
| Geno Hart | Transportation Coordinator |
| Julie Glick | Costume Supervisor |
| Alison Litton | Music Coordinator |
| Patrick Cabral | Foley Artist |
| Cynthia Merrill | Foley Artist |
| Geordy Sincavage | Foley Mixer |
| Nick Neutra | Foley Supervisor |
| Stephen Coleman | Music Programmer |
| Barney Cabral | Supervising ADR Editor |
| Paul Drenning | ADR Mixer |
| Robert Sharman | Utility Sound |
| Steven Morrow | Sound Mixer |
| Jason Blumenfeld | First Assistant Director |
| Xanthus Valan | Second Assistant Director |
| Sonia Bhalla | Second Assistant Director |
| Eric Hunsaker | Property Master |
| Nicole Hirsch Whitaker | Second Unit Director of Photography |
| Robert Althoff | Sound Recordist |
| Eveleen Bandy | Associate Producer |
| Daniel Brunt | Co-Producer |
| Michael R. Newman | Co-Producer |
| Kevin Wenger | Carpenter |
| Maxine Morris | Key Hair Stylist |
| M. Marcos Gonzalez | Set Dresser |
| Edward Quirk | 3D Artist |
| Robert Lukacs | Compositor |
| Tony Ayala | Grip |
| Andy Colvin | Steadicam Operator |
| Michael Crowe | Construction Coordinator |
| Natasha Leonnet | Digital Color Timer |
| Lorene Simpson | Digital Intermediate Producer |
| Dennis Janovici | Transportation Co-Captain |
| Paul Arthur Hartman | Leadman |
| Carlos Rodríguez | Chef |
| Jeff Johnson | Set Medic |
| Bob Weber | Post Production Accountant |
| Jeremy Walker | Unit Publicist |
| Joe Dornich | Set Production Assistant |
| Eddie Lin | Storyboard Artist |
| Kevin Moll | Studio Teacher |
| Konrad Sigurdsson | Best Boy Electric |
| Patrick Lennon | Gaffer |
| Stuart Abramson | Key Grip |
| Tim Clarke | Camera Loader |
| Heather Ignarro | Visual Effects Coordinator |
| Laura E. Little | Key Set Costumer |
| Julie Glick | Wardrobe Supervisor |
| Mark Brooks | On Set Dresser |
| Casey Mako | Second Second Assistant Director |
| Patrick Brennan | Electrician |
| Terry Atchison | Assistant Property Master |
| Donald Burghardt | First Assistant "A" Camera |
| Jenny Lee | Title Designer |
| Marta Villalobos | Set Costumer |
| Richard Dwan Jr. | Supervising Dialogue Editor |
| Virgil Sanchez | Special Effects Technician |
| Rick Kain | Stunt Driver |
| Charlie Newberry | Additional Second Assistant Camera |
| Quinton Reilly | Best Boy Grip |
| Shawn Stoddard | Dolly Grip |
| Brett F. Gates | Second Assistant Camera |
| Lisa Tutunjian | Digital Intermediate Editor |
| Matthew Dillon Noonan | Location Production Assistant |
| Amy Smolev | Assistant Accountant |
| Tara Chang | Assistant Production Coordinator |
| Laura Drake Mancini | Extras Casting Assistant |
| Betsy Royall | Local Casting |
| Joel Tokarsky | Payroll Accountant |
| John T. Maye | Production Assistant |
| Mike Hazlitt | Production Consultant |
| Patrick Cunningham | Key Production Assistant |
