 | Kurt Russell als MacReady |
 | Keith David als Childs |
 | Wilford Brimley als Blair |
 | T.K. Carter als Nauls |
 | David Clennon als Palmer |
 | Richard Dysart als Dr. Copper |
 | Charles Hallahan als Norris |
 | Peter Maloney als Bennings |
 | Richard Masur als Clark |
 | Donald Moffat als Garry |
 | Joel Polis als Fuchs |
 | Thomas G. Waites als Windows |
 | Norbert Weisser als Norwegian |
 | Larry J. Franco als Norwegian Passenger with Rifle |
 | Nate Irwin als Helicopter Pilot |
| William Zeman als Pilot |
 | Adrienne Barbeau als Computer (voice) (uncredited) |
 | John Carpenter als Norwegian (video footage) (uncredited) |
 | Jed als The Dog (uncredited) |
| Bill Lancaster | Screenplay |
| John Carpenter | Director |
| Wilbur Stark | Executive Producer |
| Todd C. Ramsay | Editor |
| David Foster | Producer |
| Dean Cundey | Director of Photography |
| Ennio Morricone | Original Music Composer |
| John M. Dwyer | Set Decoration |
| Anita Dann | Casting |
| Henry Larrecq | Art Direction |
| John J. Lloyd | Production Design |
| Stuart Cohen | Co-Producer |
| Cyrus Block | Camera Operator |
| Ronald I. Caplan | Costume Supervisor |
| Gilbert Loe | Costume Supervisor |
| Trish Keating | Costume Supervisor |
| David Lewis Yewdall | Supervising Sound Editor |
| Steve Maslow | Sound Re-Recording Mixer |
| Cliff Kohlweck | Music Editor |
| Warren Hamilton Jr. | Sound Effects Editor |
| Thomas Marshall | Gaffer |
| Barton M. Susman | Leadman |
| Raymond Stella | Camera Operator |
| Colin C. Mouat | Supervising Sound Editor |
| Charles E. Nippell | Best Boy Electric |
| Candy Artmont | Script Supervisor |
| Ken Diaz | Makeup Effects |
| Lawrence Turman | Producer |
| Larry J. Franco | Associate Producer |
| Christine Wilson | Script Supervisor |
| Ken Strain | Pilot |
| Lawrence Perry | Pilot |
| Ronald Woodward | Key Grip |
| Kris Krosskove | Dolly Grip |
| Dillard Brinson | Key Grip |
| Dave Gordon | Dolly Grip |
| Alan Howarth | Original Music Composer |
| John Carpenter | Original Music Composer |
| Phyllis Newman | Makeup Artist |
| Ken Chase | Makeup Artist |
| Rock A. Walker | Stunts |
| Ernesto Mas | Assistant Sound Editor |
| John K. Adams | Foley Supervisor |
| Fitch Cady | Unit Production Manager |
| Clint Rowe | Stunts |
| Jerry Wills | Stunts |
| Ray Kinzer | Grip |
| Michael Steele | Second Assistant Director |
| Nate Irwin | Pilot |
| Kent Hays | Stunts |
| Dick Warlock | Stunt Coordinator |
| James Callan | Painter |
| Paul R. Prince | First Assistant Camera |
| Eric Mansker | Stunts |
| Ken Strain | Stunts |
| Mark Walthour | Gaffer |
| Mentor Huebner | Production Illustrator |
| Robert Latham Brown | Production Manager |
| Graeme Murray | Set Decoration |
| Karen Kalton | Production Secretary |
| Larry Holt | Stunts |
| Melvin Jones | Stunts |
| Denver Mattson | Stunts |
| Bob Cornell | Transportation Captain |
| Kendrick Sweet | Sound Editor |
| Milton Wilson | Swing |
| Michael R. Gannon | Assistant Property Master |
| George Lawson | Driver |
| Steve Tate | Second Assistant Camera |
| Lee Routly | Special Effects |
| Chris Helcermanas-Benge | Still Photographer |
| Larry J. Franco | First Assistant Director |
| Yervant Babasin | Craft Service |
| Hans Metz | Special Effects Assistant |
| Rocky Corsini | Craft Service |
| Gary Meyer | Production Illustrator |
| James L. Hurford | Best Boy Grip |
| Anthony Cecere | Stunts |
| Roy Arbogast | Special Effects |
| Jeffrey Chernov | Second Assistant Director |
| Dan Anglin | Transportation Captain |
| Joseph R. Savko | Swing |
| Ron MacInnes | Production Assistant |
| Robin Mounsey | Technical Advisor |
| Alois Stranan | Transportation Captain |
| Spencer Hyde | Craft Service |
| Richard A. Gonzales | Swing |
| Debbie Collier | Production Secretary |
| David Geddes | Second Assistant Camera |
| Douglas Pruss | Second Assistant Camera |
| Clyde E. Bryan | First Assistant Camera |
| John K. Stirber | Special Effects Assistant |
| Michael Ploog | Production Illustrator |
| Michael A. Clifford | Special Effects |
| Len Wolfe | Best Boy Electric |
| Rob Bottin | Makeup Effects |
| Barrett J. Reid | Generator Operator |
| Rob Bottin | Makeup Effects Designer |
| Albert Whitlock | Visual Effects |
| Henry Schoessler | Visual Effects |
| John Zemansky | Property Master |
| John W. Campbell Jr. | Novel |
| David R. Anderson | Gaffer |
