 | Charles Fleischer als Roger Rabbit (voice) |
 | Kathleen Turner als Jessica Rabbit (voice) |
 | April Winchell als Young Baby Herman / Mrs. Herman (voice) |
 | Lou Hirsch als Adult Baby Herman (voice) |
 | Corey Burton als Droopy Dog (voice) |
 | Frank Welker als Bear / Beaver (voice) |
| Mark Kausler | Story |
| Pam Coats | Producer |
| Kathleen Kennedy | Executive Producer |
| Steven Spielberg | Executive Producer |
| Gary K. Wolf | Characters |
| Barry Cook | Story |
| Patrick A. Ventura | Story |
| Victor Livingston | Editor |
| Barry Cook | Director |
| Rob Minkoff | Story |
| Rob Minkoff | Executive Producer |
| Frank Marshall | Executive Producer |
| Bruce Broughton | Original Music Composer |
| Aaron Blaise | Animation |
