 | Charles Fleischer als Roger Rabbit (voice) |
 | April Winchell als Young Baby Herman / Mrs. Herman (voice) |
 | Lou Hirsch als Adult Baby Herman (voice) |
 | Corey Burton als Orderly (voice) |
 | Kathleen Turner als Jessica Rabbit (voice) |
 | Sol Pavlovsky als Raoul J. Raoul |
 | William Bronder als Sign Carrier |
| Charles Noland als Sign carrier |
 | Richard Williams als Droopy Dog (voice) |
 | June Foray als Nurse (voice) (uncredited) |
| Steven Spielberg | Executive Producer |
| Donald W. Ernst | Editor |
| James Horner | Original Music Composer |
| Rob Minkoff | Story |
| Kevin Harkey | Story |
| Don Hahn | Producer |
| Rob Minkoff | Director |
| Frank Marshall | Executive Producer |
| Bill Kopp | Story |
| Kathleen Kennedy | Executive Producer |
| Mark Kausler | Story |
| Patrick A. Ventura | Story |
| Frank Marshall | Director |
| Hiro Narita | Director of Photography |
| Gary K. Wolf | Characters |
