 | Sean Hayes als Larry |
 | Will Sasso als Curly |
 | Chris Diamantopoulos als Moe |
 | Jane Lynch als Mother Superior |
 | Sofía Vergara als Lydia |
 | Jennifer Hudson als Sister Rosemary |
 | Craig Bierko als Mac |
 | Stephen Collins als Mr. Harter |
 | Larry David als Sister Mary-Mengele |
 | Kirby Heyborne als Teddy |
 | Carly Craig als Mrs. Harter |
 | Kate Upton als Sister Bernice |
 | Marianne Leone Cooper als Sister Ricarda |
 | Brian Doyle-Murray als Monsignor Ratliffe |
 | Mike Sorrentino als The Situation |
 | Snooki als Snooki |
 | JWoww als JWoww |
 | Ronnie Ortiz-Magro als Ronnie |
 | Samantha Giancola als Sammi |
 | Skyler Gisondo als Young Moe |
 | Lance Chantiles-Wertz als Young Larry |
 | Robert Capron als Young Curly |
 | Avalon Robbins als Murph |
 | Max Charles als Peezer |
| Jake Peck als Young Teddy |
 | Isaiah Mustafa als Moe's Hip Executive |
 | Steve Tyler als Camera Man |
 | Patty Ross als Head Nurse |
 | Emy Coligado als Ling |
| Ray Collins als Carbunkle |
 | Mark Kogan als Executive |
 | Jackie Flynn als Golf Superintendent Dave Lamson |
 | Sandra Dorsey als Heavyset Woman |
 | Vince Canlas als Japanese Chef |
 | Ric Reitz als Jon Hamm |
| Caryl Lippman West als Maid |
 | Sayed Badreya als Orderly |
| Debbie Walker als Terrified Nun |
| Michael L. Kuhn als Tour Guide |
 | Pam Smith als Woman Reporter |
 | Kyla Kenedy als Balloon Girl |
 | Erin Allin O'Reilly als Nun |
 | Caitlin Colford als Nun |
| Mariann Neary als Nun |
| Jesse Farrelly als Gangbanger |
 | Patricia French als Laundry Worker |
 | Roy Jenkins als Officer Mycroft |
| Barry Guy als Staple in Hat Guy |
| Matthew L. Collins als Policeman #3 |
| Jonathan S. Kennedy als Party Security |
 | Lin Shaye als Nurse Crotchet |
 | Myron Parker Wright als Orphan |
| J.R. Fondessy als Orphan |
 | Reid Meadows als Weezer |
 | Abby Goldberg als Dancer |
| Lee Armstrong als Officer Armstrong |
 | Dwight Howard als Dwight Howard |
 | Antonio Sabàto, Jr. als Handsome Guy #1 |
| Danny Smith als French Chef |
 | Jeremy Ambler als Zoo Protester (uncredited) |
 | Mark Axelowitz als Doctor Gray (uncredited) |
 | Hannah Marie Bailey als Modern Day Orphan (uncredited) |
| Tanner Baker als Skateboarder (uncredited) |
| Chance Bartels als Party Guest (uncredited) |
| Tim Blanchard als Valet (uncredited) |
| Beth Blevins als Bus Patron (uncredited) |
| William R. Brock als Party Guest (uncredited) |
| Tiffany Burke als Nun (uncredited) |
 | Matthew Cardarople als Camera Guy (uncredited) |
| Brett Lee Clark als Party Guest (uncredited) |
| Greg Crews als Bartender (uncredited) |
| Craig Crumpton als Party Guest (uncredited) |
| Brent Duffey als Pinkberry Employee (uncredited) |
| Apple Farrelly als Child #2 (as Apple Kocsis) |
| Delonte Harris als Zoo Kid (uncredited) |
| DJ Harris als Zoo Kid (uncredited) |
| Landon Hoffman als Orphan (uncredited) |
 | Addy Miller als Modern Day Orphan (uncredited) |
 | Katherine Neslund als Woman on Street (uncredited) |
| Jade Nicolette als Modern Day Golfing Orphan (uncredited) |
| Shannon Reis als Lydia's Friend (uncredited) |
| Joel Rogers als Upscale Party Guy (uncredited) |
| Timothy Scott als Party Guest (uncredited) |
 | Richard Tavernaro als Doorman (uncredited) |
| Steve Warren als Party Guest (uncredited) |
| Marvin E. West als Party Guest (uncredited) |
| Bobby Farrelly | Director |
| Peter Farrelly | Director |
| Mike Cerrone | Screenplay |
| Bobby Farrelly | Screenplay |
| Peter Farrelly | Screenplay |
| John Debney | Original Music Composer |
| Sam Seig | Editor |
| Kerry Barden | Casting |
| Bradley Thomas | Producer |
| Matthew F. Leonetti | Director of Photography |
| Kevin Kaska | Orchestrator |
| Earl M. Benjamin | Executive Producer |
| Robert Benjamin | Executive Producer |
| Mark Charpentier | Co-Producer |
| Ellen Dumouchel | Associate Producer |
| Bobby Farrelly | Producer |
| Peter Farrelly | Producer |
| Marc S. Fischer | Executive Producer |
| Adam McCarthy | Co-Producer |
| Kris Meyer | Co-Producer |
| George Paige | Co-Executive Producer |
| J.B. Rogers | Co-Producer |
| Charles B. Wessler | Producer |
| Rick Montgomery | Casting |
| Paul Schnee | Casting |
| Arlan Jay Vetter | Production Design |
| Amy Lee Wheeler | Art Direction |
| Cindy Carr | Set Decoration |
| Denise Wingate | Costume Design |
| Amy Greene | Production Supervisor |
| Lily Gwyer-Miller | Post Production Supervisor |
| Adam McCarthy | Production Supervisor |
| Stacie McKinnon | Art Department Coordinator |
| Shannon Cain | Casting Assistant |
| Nicky Cotton | Casting Associate |
| Allison Estrin | Casting Associate |
| Michael Fredlund | Casting Assistant |
| Kimberly Helms Stewart | Casting Assistant |
| Jason James | Casting Associate |
| Norman Bielowicz | Location Manager |
| Melanie Manning | Location Scout |
| Fernand Bos | Music Editor |
| Jeff Carson | Music Editor |
| Manish Raval | Music Supervisor |
| Tom Wolfe | Music Supervisor |
| Martin Kitrosser | Script Supervisor |
| Day Permuy | Production Coordinator |
| Karl J. Martin | Set Designer |
| Ilana McAllistor | Production Accountant |
| Shane Reed | Leadman |
| Ryan Kutch | Set Dresser |
| Mark Keever | Set Dresser |
| Andy Rusk | Set Dresser |
| Burt Welleford | Set Dresser |
| Ryan Falkner | Storyboard Artist |
| John Bonaccorse | Second Second Assistant Director |
| Marc S. Fischer | Unit Production Manager |
| J.B. Rogers | First Assistant Director |
| Dawn Massaro | Second Assistant Director |
| Peter Iovino | Still Photographer |
| Jacques Jouffret | "A" Camera Operator |
| Jacques Jouffret | Steadicam Operator |
| Michael St. Hilaire | "B" Camera Operator |
| Steve Cantamessa | Production Sound Mixer |
| Gary Thomas | Boom Operator |
| Larry Madaras | Additional Editor |
| Ryan Stafford | Visual Effects Producer |
| Dan Cornwall | Gaffer |
| John A. Larsen | Supervising Sound Editor |
| James Bolt | Sound Re-Recording Mixer |
| Anna Behlmer | Sound Re-Recording Mixer |
| Andy Nelson | Sound Re-Recording Mixer |
| C. Alan Rawlins Sr. | Key Grip |
| Riko Schatke | Best Boy Grip |
| Tom Fendley | Rigging Gaffer |
| Hope Slepak | Costume Supervisor |
| Elizabeth McEntire Williams | Key Costumer |
| Cylinda Nesmith Davison | Seamstress |
| Kimberly Greene | Makeup Department Head |
| Travis Pates | Key Makeup Artist |
| Micah Laine | Makeup Artist |
| Bill 'Splat' Johnson | Makeup Artist |
| Kelly Muldoon | Hair Department Head |
| Shunika Terry | Key Hair Stylist |
| Heather Morris | Hairstylist |
| Michael Sabo | Property Master |
| Jim Passon | Color Timer |
| Joe Matthews | Musician |
| Sean Patrick Burke | Production Assistant |
| Elizabeth Davidovich | Stunt Driver |
| Emily Brobst | Stunt Double |
| Eddie Braun | Stunts |
| Keith Adams | Stunts |
| Sarah Reagin | Stunts |
| Derek Graf | Stunt Double |
| Philip Dido | Stunt Double |
| Joel Kramer | Stunt Driver |
| Tom McComas | Stunt Double |
| Ben Hernandez Bray | Stunts |
| Diana R. Lupo | Stunts |
| Eric Norris | Stunt Double |
| John Rottger | Stunts |
| Rene Mousseux | Stunt Double |
| Natasha Paul | Stunts |
| Michael Trisler | Stunts |
| Frank Torres | Stunts |
| Gerard 'Gus' Williams | Stunts |
| Madison Turner | Stunts |
| Tierre Turner | Stunt Coordinator |
| Greg Harris | Stunts |
| Kevin Abercrombie | Stunts |
| Jay Pearson | Stunts |
| R.J. De La Fuente | Stunt Double |
| Cody Robinson | Stunt Double |
