 | J. Robert Oppenheimer als Self (archive footage) |
 | Ellen Bradbury Reid als Self - Daughter of Los Alamos Scientist |
 | Christopher Nolan als Self - Writer / Director, "Oppenheimer" |
 | Jon Else als Self - Filmmaker, "The Day After Trinity" |
| Kai Bird als Self - Co-Author, "American Prometheus" |
 | Bill Nye als Self - Science Educator |
| Richard Rhodes als Self - Author, "The Making of the Atomic Bomb" |
| Mareena Robinson Snowden als Self - Nuclear Security Expert |
| Alan B. Carr als Self - Senior Historian, Los Alamos National Laboratory |
| Gregg Herken als Self - Author, "Brotherhood of the Bomb" |
| Jennet Conant als Self - Author, "109 East Palace" |
| David Eisenbach als Self - History Professor, Columbia University |
| Alex Wellerstein als Self - Nuclear Historian |
| Martin J. Sherwin als Self - Co-Author, "American Prometheus" (voice) |
 | Michio Kaku als Self - Theoretical Physicist |
 | Leslie Groves als Self - Director, Manhattan Project (voice) (archive footage) |
| Charles Oppenheimer als Self - Grandson |
| Robert Christy als Self - Theoretical Physicist (voice) (archive footage) |
| Robert S. Norris als Self - Author, "Racing for the Bomb" |
| Hideko Tamura als Self - Hiroshima Survivor (Age 10) |
| Roy Glauber als Self - Scientist, Manhattan Project (voice) (archive footage) |
 | Edward Teller als Self - Theoretical Physicist (archive footage) |
 | Eleanor Roosevelt als Self (archive footage) |
 | Judy Woodruff als Self (voice) (archive footage) |
 | Adolf Hitler als Self (archive footage) |
 | Vladimir Putin als Self (archive Footage) |
 | Xi Jinping als Self (archive Footage) |
 | Albert Einstein als Self (archive Footage) |
| Christopher Cassel | Director |
| Liz Cole | Executive Producer |
| Molly O'Brien | Executive Producer |
| Elizabeth Fischer | Executive Producer |
| Christopher Cassel | Executive Producer |
| Tim Metzger | Director of Photography |
| Barry Blaschke | Editor |
| Rosie Walunas | Editor |
| Anna Drubich | Original Music Composer |
| Joel Schneider | Producer |
| Thaddeus Bouska | Producer |
| Eleanor West | Co-Producer |
| Laura Juncadella | Associate Producer |
| Kira Leinonen | Line Producer |
| Micky Haney | Production Manager |
| Marisa Reilly | Head of Production |
| Zeke Dunn | Line Producer |
| Amanda Moore | Production Manager |
| Brandon Ripley | Additional Director of Photography |
| George Alvarez | First Assistant Camera |
| Ben Carolan | First Assistant Camera |
| Will Dauel | First Assistant Camera |
| Coburn Erskine | First Assistant Camera |
| Andrew Goh | First Assistant Camera |
| Meghan Noce | First Assistant Camera |
| Joshua Jones | Second Assistant Camera |
| Nick Misisco | Second Assistant Camera |
| Donovon O'Neill | Second Assistant Camera |
| Oleksandr Shvachko | Second Assistant Camera |
| Madison Stonefield | Second Assistant Camera |
| Ryan Halsey | Gaffer |
| Curt Jentsch | Gaffer |
| Xavier Gomez | Gaffer |
| Greg Smith | Gaffer |
| Isaak van der Meulen | Gaffer |
| Michael Wilson | Gaffer |
| Phillip Yu | Gaffer |
| Aaron Johnson | Grip |
| Colleen Newberry | Grip |
| Jose "FX" Rodriquez | Grip |
| Henry Sime | Grip |
| Brandon Taylor | Grip |
| James Wilson | Grip |
| Phillip Yu | Grip |
| Christopher Burke | Swing |
| Dylan Henderson | Swing |
| David Hsu | Swing |
| Joe Kosty | Swing |
| David Persaud | Swing |
| Caley Bisson | Production Design |
| Sarah Loeppke | Production Design |
| Anna Kendall | Set Dresser |
| David Thompson | Sound Mixer |
| Adriano Bravo | Sound Mixer |
| Stu Chacon | Sound Mixer |
| Dave Richards | Sound Mixer |
| Wally Skinner | Sound Mixer |
| Tony Smith | Sound Mixer |
| Christopher Nolan | Thanks |
| Emma Thomas | Thanks |
| Emma Belcher | Thanks |
| Michael Oppenheimer | Thanks |
| Dr. Jorge López | Thanks |
| Hideko Tamura | Thanks |
| Noriko Hansen | Thanks |
| John "Drew" Hamilton | Thanks |
| Alex Pilkington | Post Production Supervisor |
| Jake Vest | Post Production Coordinator |
| Sophia Oliveri | Assistant Editor |
| Mike Sweeney | Animation Director |
| Jonathan Hunt | Art Direction |
| Jeff Gess | Art Direction |
| Mike Sweeney | Animation |
| Jeff Gess | Animation |
| Jonathan Hunt | Animation |
| Shane Douberly | Animation |
| Katie Janse | Producer |
| Anthony Campagna | Digital Intermediate Colorist |
| Ben Kiviat | Digital Intermediate Editor |
| Dan Walsh | Supervising Sound Editor |
| Dan Walsh | Sound Re-Recording Mixer |
| Joe DiCosola | Sound Effects Editor |
| Tanner DeMain | Production Assistant |
| DeDric Hohman | Production Assistant |
| Mikey Slavich | Production Assistant |
| Edgar Polkat | Production Assistant |
| Sam Worrin | Production Assistant |
