 | Anthony Hopkins als Dr. Hannibal Lecter |
 | Julianne Moore als Clarice M. Starling |
 | Gary Oldman als Mason Verger |
 | Ray Liotta als Paul Krendler |
 | Giancarlo Giannini als Insp. Renaldo Pazzi |
 | Zeljko Ivanek als Dr. Cordell Doemling |
 | Frankie Faison als Barney Matthews |
 | Francesca Neri als Allegra Pazzi |
 | Hazelle Goodman als Evelda Drumgo |
 | David Andrews als FBI Agent Pearsall |
 | Francis Guinan als FBI Asst. Director Noonan |
 | James Opher als DEA Agent John Eldridge |
 | Enrico Lo Verso als Gnocco |
 | Ivano Marescotti als Carlo |
 | Fabrizio Gifuni als Matteo |
 | Alex Corrado als Piero |
 | Marco Greco als Tommaso |
 | Robert Rietti als Sogliato |
 | Terry Serpico als Officer Bolton |
 | Boyd Kestner als Special Agent Burke |
| Peter Shaw als Special Agent John Brigham |
| Kent Linville als Geoffrey, FBI Mail Boy |
 | Don McManus als Asst. Mayor Benny Holcombe |
| Harold Ginn als Larkin Wayne, I.A.B. |
 | Ted Koch als BATF Agent Bob Sneed |
| William Powell-Blair als FBI Agent |
 | Aaron Craig als 'Il Mostro' Detective |
 | Andrea Piedimonte als Agent Franco Benetti |
 | Ennio Coltorti als Ricci |
 | Mark Margolis als Perfume Expert |
 | Ajay Naidu als Perfume Expert |
 | Kelly Piper als Perfume Expert |
 | Judie Aronson als News Reporter |
 | Derrick Simmons als Evelda Drumgo's Bodyguard |
 | Chuck Jeffreys als Evelda Drumgo's Bodyguard |
 | Gano Grills als Evelda Drumgo's Bodyguard |
 | Giannina Facio als Verger's Fingerprint Technician |
 | Renne Gjoni als FBI Agent Michaels |
| Roberta Armani als Theatergoer |
| Branko Lustig | Executive Producer |
| Ridley Scott | Producer |
| Pietro Scalia | Editor |
| Martha De Laurentiis | Producer |
| Steven Zaillian | Screenplay |
| Dino De Laurentiis | Producer |
| David Mamet | Screenplay |
| Hans Zimmer | Original Music Composer |
| Thomas Harris | Novel |
| John Mathieson | Director of Photography |
| Ridley Scott | Director |
| Crispian Sallis | Set Decoration |
| Dan Hegeman | Sound Effects Editor |
| Scott Sanders | Sound Effects Editor |
| Christopher Assells | Sound Effects Editor |
| Emma Norton | Visual Effects Producer |
| Klemens Becker | Steadicam Operator |
| Daniele Massaccesi | Additional Camera |
| Vicki Hiatt | Music Editor |
| David Crank | Art Direction |
| Norris Spencer | Production Design |
| Halina Gebarowicz | Assistant Art Director |
| Susan Maye | Art Department Coordinator |
| Marc Streitenfeld | Music Editor |
| Mike Barbour | Picture Car Coordinator |
| Dan Bronson | Costume Supervisor |
| Janty Yates | Costume Design |
| Per Hallberg | Supervising Sound Editor |
| Laurent Hugueniot | CG Supervisor |
| David M. Dunlap | Camera Operator |
| Bill O'Leary | Gaffer |
| Bob Foster | Transportation Coordinator |
| John T. Cucci | Foley |
| Jon Title | Sound Effects Editor |
| Phil Neilson | Stunt Coordinator |
| Elisabetta De Leonardis | Hairstylist |
| Dan O'Connell | Foley |
| Doug Hemphill | Sound Re-Recording Mixer |
| Louis DiGiaimo | Casting |
| Fabrizio Sforza | Makeup Department Head |
| Karen Baker Landers | Supervising Sound Editor |
| Richard Blankenship | Construction Coordinator |
| Dino DiMuro | Sound Effects Editor |
| Paul Massey | Sound Re-Recording Mixer |
| Marci R. Johnson | Set Costumer |
| Barbara De Leonardis | Hairstylist |
| Doug Huszti | Assistant Art Director |
| Linda M. Boyland | Set Costumer |
| Aaron F. Quarles | Hairstylist |
| Alessandra Sampaolo | Makeup Artist |
| Rob Harris | Unit Publicist |
| Alberico Novelli | Gaffer |
| Catharine Fletcher Incaprera | Set Costumer |
| Nicholas Atkinson | Visual Effects Editor |
| Tim Burke | Visual Effects Supervisor |
| Phil Bray | Still Photographer |
| Richie Ford | Rigging Gaffer |
| Luca Kouimelis | Script Supervisor |
| Chisako Yokoyama | First Assistant Editor |
| Pier Luigi Basile | Supervising Art Director |
| Michelle Pazer | ADR Editor |
| Douglas T. Madison | Property Master |
| Peter Staubli | Foley Editor |
| Chris Hogan | Dialogue Editor |
| Jessica Gallavan | Supervising ADR Editor |
| Paul Jyrälä | Foley Editor |
| David A. Cohen | Dialogue Editor |
| Tim Gomillion | Sound Recordist |
| Tim McColm | Sound Recordist |
| O.J. Connell III | Boom Operator |
| Dennis Rogers | Sound Recordist |
| Philip A. Hess | Foley Editor |
| Alexander Witt | Second Unit Director of Photography |
| Danny Michael | Production Sound Mixer |
| Lauren Stephens | Dialogue Editor |
| Andrew Schmetterling | Boom Operator |
| Alexander Witt | Second Unit Director |
| Brian Smyj | Stunts |
| Cinda-Lin James | Stunts |
