 | Ben Stiller als Alex (voice) |
 | Chris Rock als Marty / Additional Zebras (voice) |
 | David Schwimmer als Melman (voice) |
 | Jada Pinkett Smith als Gloria (voice) |
 | Sacha Baron Cohen als Julien (voice) |
 | Cedric the Entertainer als Maurice (voice) |
 | Andy Richter als Mort (voice) |
 | Bernie Mac als Zuba (voice) |
 | Alec Baldwin als Makunga (voice) |
 | Sherri Shepherd als Mom (voice) |
 | Will.i.am als Moto Moto (voice) |
 | Elisa Gabrielli als Nana (voice) |
 | Tom McGrath als Skipper / Lemur (voice) |
 | Chris Miller als Kowalski (voice) |
 | Christopher Knights als Private (voice) |
 | Conrad Vernon als Mason (voice) |
 | Quinn Dempsey Stiller als Baby Alex (voice) |
 | Declan Swift als Baby Alex (voice) |
 | Fred Tatasciore als Teetsi / Poacher #1 / Elephant (voice) |
 | Eric Darnell als Joe the Witch Doctor / Poacher #2 (voice) |
 | Willow Smith als Baby Glorida (voice) |
 | Thomas Stanley als Baby Marty (voice) |
 | Zachary Gordon als Baby Melman (voice) |
 | Meredith Vieira als Newscaster (voice) |
 | Lesley Stahl als Newscaster (voice) |
 | Al Roker als Newscaster (voice) |
 | David Soren als Lemur (voice) |
 | Phil LaMarr als Guide (voice) |
 | Stephen Kearin als Stephen the Giraffe / Tourist with Video Camera / Rhino (voice) |
 | Dan O'Connor als Tourist with University Shirt / Cape Buffalo (voice) |
 | Edie Mirman als Telephone Recording (voice) |
 | Fergie als Hippo Girlfriend (voice) |
 | Harland Williams als Additional Giraffe (voice) |
 | Danny Jacobs als Tourist with New York T-Shirt (voice) |
 | Bridget Hoffman als Female Tourist (voice) |
 | Terrence Hardy Jr. als Cub (voice) |
 | Conner Rayburn als Little Giraffe (voice) |
 | Holly Dorff als Fish (voice) |
 | David P. Smith als Bobby the Dik Dik (voice) |
 | Lynnanne Zager als Lioness (voice) |
 | Jackie Gonneau als Additional Dik Dik (voice) |
| Eric Darnell | Director |
| Tom McGrath | Director |
| Emilio Ghorayeb | Animation |
| Paul Carrera | First Assistant Editor |
| Kevin Kaska | Orchestrator |
| Ryan Savas | Art Department Assistant |
| John O'Sullivan | Systems Administrators & Support |
| Jannette Eng | Production Supervisor |
| Craig Rittenbaum | Production Supervisor |
| Bill Diaz | Animation |
| Alexander Fleisig | Animation |
| Ron Pucherelli | Animation |
| David Spivack | Animation |
| Hans Zimmer | Original Music Composer |
| Alan Meyerson | Scoring Mixer |
| Evan Smyth | Software Engineer |
| Tony Mitzelfelt | Lighting Artist |
| Mark Berrow | Musician |
| Kevin Edwards | Lighting Artist |
| Jessi Stumpfel | Lighting Artist |
| Jessie Carbonaro | Production Supervisor |
| Rick Giovinazzo | Orchestrator |
| Randy Thom | Sound Designer |
| Ryan Gong | Animation |
| Rani Naamani | Animation |
| Jerome Fournier | Background Designer |
| Will Files | Supervising Sound Editor |
| Jin Liou | CG Supervisor |
| Eric Roth | Lighting Artist |
| Gavin Greenaway | Conductor |
| Jeffrey Joe | Animation |
| Bryce McGovern | Animation |
| Cory Rogers | Animation |
| Tony Cosanella | Thanks |
| Mireille Soria | Producer |
| Jeff Lee | Systems Administrators & Support |
| Annmarie Koenig | CG Supervisor |
| Mark A. Decker | Lighting Artist |
| Rupali Parekh | Lighting Artist |
| Joyce Powell | Lighting Artist |
| Hannah Sherman | Lighting Artist |
| Matt Robertson | Administration |
| Debbie L. O'Keeffe | Thanks |
| Luis Jardim | Musician |
| Spencer Filichia | Production Supervisor |
| Will.i.am | Songs |
| David Yanover | Post Production Supervisor |
| Bart Feliciano | Systems Administrators & Support |
| Asha Kiran Mateti | First Assistant Director |
| Jim Passon | Color Timer |
| Will Erokan | Editorial Production Assistant |
| Ben Roy | Casting Assistant |
| Chris Bancroft | Animation |
| Mariko Hoshi | Animation |
| Serguei Kouchnerov | Animation |
| Mark Roennigke | Animation |
| James Beshears | Executive In Charge Of Post Production |
| Natalia Cronembold | Post Production Assistant |
| Lorne Balfe | Additional Music |
| Tom Holkenborg | Additional Music |
| Jonathan Pollack | Creative Consultant |
| Jonathan Williams | Musician |
| Romney T. Marino | Production Coordinator |
| Derek Mann | Systems Administrators & Support |
| David Hail | Publicist |
| Lei Han | Lighting Artist |
| Meredith Narrowe | Production Coordinator |
| Christopher Leahy | Production Supervisor |
| Andre de Oliviera Araujo | Production Supervisor |
| Manuel Aparicio | Animation |
| Raffi Parikian | Systems Administrators & Support |
| Daniel Rich | Systems Administrators & Support |
| Richard Harvey | Musician |
| Christine Nguyen | Production Coordinator |
| James Bolt | Sound Mixer |
| Yoriko Ito | Production Illustrator |
| James Wood Wilson | Production Illustrator |
| Johnny Duguid | Production Intern |
| Rain Angeles | Systems Administrators & Support |
| Megan McDonald | Production Coordinator |
| Dustin Cawood | Sound Effects Editor |
| Tomoyuki Harashima | Animation |
| Titus Fotso | Thanks |
| Olivier Pinol | Sequence Leads |
| Terri Anderson | Finance |
| Ariandy Chandra | Title Designer |
| Susan Hayden | CG Supervisor |
| Dave Walvoord | CG Supervisor |
| Mo Henry | Negative Cutter |
| Sebastien Chort | Lighting Artist |
| Gabriel White | Lighting Artist |
| Brendan O’Connor | Production Coordinator |
| Ryan Genji Thomas | Production Coordinator |
| Cory Mandel | Sound Re-Recording Mixer |
| Julien Bocabeille | Animation |
| Patrick Bonneau | Animation |
| Nicolas A. Chauvelot | Animation |
| John Lai | Lighting Artist |
| Cecile Picard | Sculptor |
| Gregg Carrier | Software Engineer |
| Denis Couchon | Supervising Animator |
| Daniel Ortiz | Assistant Editor |
| Oth Khotsimeuang | Lighting Artist |
| Michel Kinfoussia | Lighting Artist |
| Meredith McIvor | Production Coordinator |
| Claudia Southmartin | Production Manager |
| Jason Bertsch | Production Supervisor |
| Robyn Mesher | Production Supervisor |
| Erik Vignau | Production Supervisor |
| Dennie Thorpe | Foley |
| Rachel Bolt | Musician |
| Morten Folmer Nielsen | ADR Editor |
| Geoff Zanelli | Additional Music |
| Ariga Parseghian | Finance |
| Tom Pigott-Smith | Musician |
| Alfred Young | Lighting Artist |
| Karen L. Whitaker | Production Coordinator |
| Alison Fedrick Donahue | Production Supervisor |
| Jason Oliver | Sound Recordist |
| Guillermo Careaga | Animation |
| Melanie Cordan | Animation |
| Lou Dellarosa | Animation |
| Ben Rush | Animation |
| Jim Dooley | Additional Music |
| Dee Lewis Clay | Additional Music |
| E. Larry Oatfield | Foley Editor |
| Paul Kegg | Musician |
| Andrew Crowley | Musician |
| Will Files | Sound Designer |
| Laura Grieve | CG Supervisor |
| Anthony Hodgson | Supervising Animator |
| Alex McDonnell | Assistant Editor |
| Stanley Kwong | Lighting Artist |
| Emily Yi | Lighting Artist |
| Betty Tom | Production Accountant |
| Heitor Pereira | Musician |
| Mac Smith | Sound Effects Editor |
| Tom Lalley | Sound Engineer |
| Katrina Conwright | Animation |
| Eric Lessard | Animation |
| Yeko Ladzekpo-Cole | Thanks |
| H. Lee Peterson | Editor |
| Leslee Feldman | Casting |
| Frank Ricotti | Musician |
| Satnam Ramgotra | Musician |
| Cassidy Curtis | Supervising Animator |
| David Isetta | Production Coordinator |
| Chris McClintock | Production Coordinator |
| Blake R. Cornett | Sound Recordist |
| Kevin Vassey | Animation |
| Scott Lafleur | Animation |
| Mark A. Hester | Editor |
| Kendal Cronkhite | Production Design |
| Angela Ensele | Modeling |
| Wendy Berry Campbell | Production Supervisor |
| Milton E. Rodriguez-Rios | CG Supervisor |
| Jason Schleifer | Supervising Animator |
| John R. Miller | Systems Administrators & Support |
| Tommy Wright | Lighting Artist |
| Adrienne Belai | Casting Assistant |
| Bruce Fowler | Orchestrator |
| Carl Rydlund | Orchestrator |
| Andrew Birch | Post-Production Manager |
| John Hill | Supervising Animator |
| Jason Spencer-Galsworthy | Supervising Animator |
| Adam Chin | Lighting Artist |
| Kirsten Drummond | Lighting Artist |
| Ka Yaw Tan | Lighting Artist |
| Jennifer Dahlman | Production Manager |
| Andy Nelson | Sound Re-Recording Mixer |
| Dennis Leonard | Supervising Sound Editor |
| Tom Broderick | Score Engineer |
| Frank Marocco | Musician |
| Nicholas Bucknall | Musician |
| Steve Mair | Musician |
| Hans Zimmer | Musician |
| Dan Newell | Musician |
| Jonathan Evans-Jones | Musician |
| Sunny Ye | Production Coordinator |
| Paul Chung | Supervising Animator |
| Timothy Bud McMahon | Lighting Artist |
| Diana K. Lee | Production Supervisor |
| Mark Behm | Animation |
| Maxime Maleo | Animation |
| David Rader | Animation |
| Mark Swift | Producer |
| Scott Chapin | Systems Administrators & Support |
| Chris Clad | Musician |
| Vicki Hunter | Finance |
| Tracey Dispensa | Production Coordinator |
| Sean Mahoney | Supervising Animator |
| Stephanie Huber | Production Coordinator |
| Diana K. Lee | Production Coordinator |
| John Colt | Production Supervisor |
| Pete Horner | Sound Effects Editor |
| Bailey Brent | Animation |
| Carlos Fernandez Puertolas | Animation |
| Kevan Shorey | Animation |
| Greg Gladstone | Visual Effects |
| Max Rodriguez | Visual Effects Coordinator |
| Joshua West | Modeling |
| Tobin Jones | Visual Effects |
| Dane Stogner | Animation |
| Olive Lin | Visual Effects |
| Brett Nystul | Modeling |
| Kenard Pak | Visual Development |
| Philip To | Animation |
| Nadja Bonacina | Modeling |
| Bryan Gregg LaShelle | Visual Development |
| Ji Hyun Yoon | Visual Effects |
| Pete Oswald | Character Designer |
| Don Venhaus | Animation |
| Jeff Wagner | Modeling |
| Steve McGrath | Modeling |
| Travis Koller | Visual Development |
| Scott Singer | Visual Effects Supervisor |
| Jason Rickwald | Visual Effects |
| Benjamin Andersen | VFX Artist |
| Lindsey Caplan | Visual Effects Coordinator |
| Nara Youn | Animation |
| Alex Patanjo | Visual Effects |
| Stephanie Siebert | VFX Artist |
| Philippe Gluckman | Visual Effects Supervisor |
| Jeff Budsberg | Visual Effects |
| Eunjin Suh | Animation |
| Ruben Perez | Visual Development |
| Jason Waltman | VFX Artist |
| Greg Whittaker | Animation |
| Craig Kellman | Character Designer |
| Paul Schoeni | Modeling |
| Doug Pierce | Visual Development |
| Andy Bialk | Character Designer |
| Jinwoo Lee | Modeling |
| Kory Heinzen | Visual Development |
| Fangwei Lee | VFX Artist |
| Jonathan Groff | Creative Consultant |
| Eric Darnell | Writer |
| Tom McGrath | Writer |
| Etan Cohen | Writer |
| Bernie Mac | In Memory Of |
