 | Jacob Tremblay als Elmer Elevator (voice) |
 | Gaten Matarazzo als Boris the Dragon (voice) |
 | Golshifteh Farahani als Dela Elevator (voice) |
 | Dianne Wiest als Iris the Rhinoceros (voice) |
 | Rita Moreno als Mrs. McClaren (voice) |
 | Chris O'Dowd als Kwan the Macaque (voice) |
 | Judy Greer als Soda the Whale (voice) |
 | Alan Cumming als Cornelius the Crocodile (voice) |
 | Yara Shahidi als Callie (voice) |
 | Jackie Earle Haley als Tamir the Tarsier (voice) |
 | Mary Kay Place als Narrator (voice) |
 | Leighton Meester als Sasha (voice) |
 | Spence Moore II als George (voice) |
 | Adam Brody als Bob (voice) |
 | Charlyne Yi als Magda (voice) |
 | Jack S. A. Smith als Eugene (voice) |
| Maggie Lincoln als Gertie (voice) |
 | Whoopi Goldberg als Cat (voice) |
 | Ian McShane als Saiwa (voice) |
| Gerry Shirren | Executive Producer |
| Paul Young | Producer |
| Ruth Coady | Executive Producer |
| Bonnie Curtis | Producer |
| Nora Twomey | Director |
| Julie Lynn | Producer |
| Ruth Stiles Gannett | Book |
| Meg LeFauve | Screenplay |
| Meg LeFauve | Story |
| Alan Moloney | Executive Producer |
| Áine Mc Guinness | Art Direction |
| Meg LeFauve | Executive Producer |
| Tomm Moore | Executive Producer |
| Jeff Danna | Original Music Composer |
| Mychael Danna | Original Music Composer |
| John C. Morgan | Story |
| John C. Morgan | Executive Producer |
| Zahra Dowlatabadi | Line Producer |
| Amy Lippens | Casting |
| Richie Cody | Editor |
| Darren T. Holmes | Editor |
| Justin M. Davey | Supervising Sound Editor |
| Justin M. Davey | Sound Re-Recording Mixer |
| Zach Seivers | Supervising Sound Editor |
| Zach Seivers | Sound Re-Recording Mixer |
| Rosa Ballester Cabo | Production Designer |
| Giovanna Ferrari | Head of Story |
| Giovanna Ferrari | Animation Director |
| Louise Bagnall | Assistant Director |
| Fabian Erlinghäuser | Assistant Director |
| Mark Mullery | Assistant Director |
| Katja Schumann | Head of Production |
| Isabel Lozano | Production Manager |
| Narissa Schander | Visual Effects Designer |
| Louise McCague | Story Coordinator |
| Lisa Dennis | Post Production Supervisor |
| Owen Peters | Assistant Editor |
| Léo Weiss | Layout Supervisor |
| Antonia Yordanova Gancheva | Layout Supervisor |
| Andrzej Radka | Animation Supervisor |
| Svend Andreas Rothmann Bonde | Animation Supervisor |
| Geoff King | Lead Animator |
| Allan Michaut | Lead Animator |
| Mathilde Vachet | Lead Animator |
| Bryony Evans | Animation |
| Anita Gaughan | Animation |
| Basil Malek | Animation |
| Lily Bernard | Visual Development |
| Lily Bernard | Conceptual Design |
| Tomm Moore | Visual Development |
| Tomm Moore | Conceptual Design |
| Ross Stewart | Visual Development |
| Ross Stewart | Conceptual Design |
| Alessandro Toccaceli | Lead Character Designer |
| Maria Blowers | Character Designer |
| Elle Power | Character Designer |
| Andrzej Radka | Character Designer |
| Erin Overmann | Prop Designer |
| Bonnie Mier | Prop Designer |
| Paul Kavanagh | Prop Designer |
| Maca Gil | Storyboard Artist |
| Julien Regnard | Storyboard Artist |
| Iker Maidagan | Storyboard Artist |
| Lara Madden | Animation Coordinator |
| Emma Hanley | Animation Coordinator |
| Narissa Schander | Visual Effects Supervisor |
| Lynn Biederer | VFX Artist |
| Paulo Passaro | VFX Artist |
| Nicole Storck | VFX Artist |
| Steven McClurg | Visual Effects Coordinator |
| Anna FitzSimons | Visual Effects Coordinator |
| Paul Ó Muiris | Compositing Supervisor |
| Damien Bayard | Compositing Artist |
| Luis Betancourt | Compositing Artist |
| Benoit Pirenne | Compositing Artist |
| Kristi Lugo | Casting Assistant |
| Michael Culleton | Production Accountant |
| Natasha Leonnet | Colorist |
| Justin M. Davey | Sound Designer |
| Jason W. Jennings | Sound Designer |
| Diego Perez | Sound Designer |
| Tim Walston | Sound Designer |
| Christopher Battaglia | Sound Effects Designer |
| Tim Farrell | Sound Effects Designer |
| Zach Seivers | ADR Supervisor |
| Beso Kacharava | Foley Supervisor |
| Biko Gogaladze | Foley Artist |
| Giorgi Lekishvili | Foley Mixer |
| Alexander Sanikidze | Foley Editor |
| Thomas J. O'Connell | ADR Mixer |
| Jason Oliver | ADR Mixer |
| Moira Marquis | Music Editor |
| Rohit Kelkar | Animation |
