 | Dwayne Johnson als Capt. Charles 'Chuck' Baker (voice) |
 | Seann William Scott als Skiff (voice) |
 | Jessica Biel als Neera (voice) |
 | Justin Long als Lem / Rover (voice) |
 | Gary Oldman als General Grawl (voice) |
 | John Cleese als Professor Kipple (voice) |
 | Alan Marriott als Glar (voice) |
 | Freddie Benedict als Eckle (voice) |
 | Mathew Horne als Soldier Vesklin (voice) |
 | James Corden als Soldier Vernkot (voice) |
 | Lewis Macleod als Additional Voices (voice) |
 | Rupert Degas als Additional Voices / Chief Gorlock (voice) |
 | Rebecca Front als Additional Voices (voice) |
 | Vincent Marzello als Additional Voices (voice) |
 | Emma Tate als Additional Voices (voice) |
 | Pete Atkin als Additional Voices (voice) |
 | Laurence Bouvard als Additional Voices (voice) |
 | Brian Bowles als Additional Voices (voice) |
| Guy Collins | Producer |
| Ignacio Pérez Dolset | Producer |
| Joe Stillman | Writer |
| Jorge Blanco | Director |
| Fernando Juárez | Art Direction |
| Alex Rodríguez | Editor |
| James Seymour Brett | Original Music Composer |
| Yannick Honore | Animation |
| Chris Brown | Music |
| Martin Cantwell | Sound Effects Designer |
| Javier Abad | Co-Director |
| Marcos Martínez | Co-Director |
| Carolina Jiménez | Layout |
| Javier Abad | Idea |
| Jorge Blanco | Idea |
| Marcos Martínez | Idea |
| Ignacio Pérez Dolset | Idea |
| Ruth Lambert | Casting |
| Robert McGee | Casting |
| Ed Colyer | Foley Mixer |
| Peter Burgis | Foley Artist |
| Andie Derrick | Foley Artist |
| Chris Burdon | Sound Re-Recording Mixer |
| Max Bygrave | Sound Effects Editor |
| Larry Hopkins | Sound Mixer |
| Roberto H.G. | Sound Editor |
| Álvaro de Iscar | Sound Editor |
| Derek Trigg | Foley Editor |
| Jack Stew | Foley Artist |
| James Harrison | Sound Effects |
| Nick Foley | ADR Mixer |
| Mercedes Gamero | Executive Producer |
| Ricardo García Arrojo | Executive Producer |
| Peter D. Graves | Executive Producer |
| Albie Hecht | Executive Producer |
| Michael Maker | Executive Producer |
| Stephen Margolis | Executive Producer |
| Albert Martínez Martín | Executive Producer |
| Patrick Meehan | Executive Producer |
| Javier Dolset | Executive Producer |
| Juan Antonio Perez Ramirez | Executive Producer |
| Mercedes Rey | Executive Producer |
| José A. Rodriguez Diaz | Executive Producer |
| Michael Ryan | Executive Producer |
| Julian Muñoz Romero | Production Design |
| Joseph Stracey | Sound Effects Designer |
| Karen Lindsay-Stewart | Casting |
| Danny Hambrook | Sound Effects Editor |
| Dillon Bennett | Sound Editor |
| Glen Gathard | Foley Mixer |
