 | Tobin Bell als John Kramer / Jigsaw |
 | Costas Mandylor als Mark Hoffman |
 | Scott Patterson als Agent Strahm |
 | Betsy Russell als Jill Tuck |
 | Lyriq Bent als Rigg |
 | Athena Karkanis als Agent Perez |
 | Louis Ferreira als Art |
 | Simon Reynolds als Lamanna |
 | Donnie Wahlberg als Eric Matthews |
 | Angus Macfadyen als Jeff Denlon |
 | Shawnee Smith als Amanda Young |
 | Bahar Soomekh als Lynn Denlon |
 | Dina Meyer als Detective Allison Kerry |
 | Mike Realba als Fisk |
 | Marty Adams als Ivan |
 | Sarain Boylan als Brenda |
 | Billy Otis als Cecill |
 | James Van Patten als Dr. Heffner / Coroner |
 | David Boyce als Pathologist |
 | Kevin Rushton als Trevor |
 | Julian Richings als Vagrant |
 | Kelly Jones als SWAT Pete |
 | Ingrid Hart als Tracy Rigg |
 | Niamh Wilson als Corbett Denlon |
 | Janet Land als Morgan |
 | Ron Lea als Rex |
 | Joanne Boland als Crime Scene Photographer |
| Zoe Heath als Lab Technician |
| Bill Vibert als Young Cop |
 | Eric Gores als Matt |
 | Devon Bostick als Derek |
 | Tony Nappo als Gus |
 | Emmanuelle Vaugier als Addison Corday |
 | Noam Jenkins als Michael Marks |
 | Mike Butters als Paul Leahy |
 | J. LaRose als Troy |
 | Oren Koules als The Man |
| Alison Luther als Young Girl |
 | Kim Roberts als Nurse Deborah |
| David Webster als Dr. Steve |
| Sandra Manson als Nurse Patti |
| Shauna Black als Additional Voice Talent (voice) |
 | Darrell Dennis als Additional Voice Talent (voice) |
 | Tracey Ferencz als Additional Voice Talent (voice) |
| Catherine Fitch als Additional Voice Talent (voice) |
 | Christopher Marren als Additional Voice Talent (voice) |
| Christopher Morris als Additional Voice Talent (voice) |
 | Geoffrey Pounsett als Additional Voice Talent (voice) |
| Charlie Clouser | Original Music Composer |
| Kevin Greutert | Editor |
| James Wan | Executive Producer |
| Peter Block | Executive Producer |
| Gregg Hoffman | Producer |
| David A. Armstrong | Director of Photography |
| Darren Lynn Bousman | Director |
| Stacey Testro | Executive Producer |
| Jason Constantine | Executive Producer |
| Oren Koules | Producer |
| Marcus Dunstan | Screenplay |
| Brett Sullivan | Editor |
| Leigh Whannell | Executive Producer |
| Mark Burg | Producer |
| Alex Kavanagh | Costume Design |
| Patrick Melton | Screenplay |
| Daniel J. Heffner | Executive Producer |
| Liesl Deslauriers | Set Decoration |
| David Hackl | Production Design |
| Stephanie Gorin | Casting |
| Anthony Ianni | Art Direction |
| Steve Baine | Foley |
| Ernest Spiteri | First Assistant Camera |
| Monty Montgomerie | Key Grip |
| Trevor Lewis | Digital Intermediate |
| François Dagenais | Prosthetic Makeup Artist |
| Stephen Myers | Electrician |
| Jon Campfens | Visual Effects Supervisor |
| Brian Gedge | Camera Operator |
| Ira Cohen | Gaffer |
| Jonathan Scott Miller | Music Supervisor |
| James Jeffery | Camera Operator |
| Robert DaPrato | Rigging Grip |
| Candice Ornstein | Key Makeup Artist |
| Jason Hopfner | Boom Operator |
| Allan Fung | Dialogue Editor |
| Thomas Care | Dolly Grip |
| Patrick Melton | Story |
| Thomas Fenton | Story |
| John Douglas Smith | Supervising Sound Editor |
| Voytek Kufner | Animation |
| Stephanie Ingram | Key Hair Stylist |
| Tracy Shaw | Rigging Grip |
| Jonathan Platt | Music Supervisor |
| Marcus Dunstan | Story |
| Keith Elliott | Sound Re-Recording Mixer |
| Mark Gingras | Supervising Sound Editor |
| Elizabeth Scherberger | First Assistant Director |
| Tom Bjelic | Sound Effects Editor |
| Jamie Burke | Construction Coordinator |
| John Laing | ADR Editor |
| Christopher Takacs | Best Boy Electrician |
| Pete Daprato | Rigging Grip |
| Steve Wilkie | Still Photographer |
| Nick Iannelli | Digital Intermediate |
| Chris MacKenzie | Digital Intermediate |
| Paul Intson | Music Editor |
| James R. Murray | Property Master |
| Andrew Tay | Sound Re-Recording Mixer |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| Peter Denomme | Visual Effects Producer |
| Kevin LeBlanc | First Assistant Camera |
| Ciara Brennan | Costume Coordinator |
| Elizabeth Tremblay | Script Supervisor |
| Sean Dawes | Electrician |
| Philip Charles Whitfield | Electrician |
| Nick Paulozza | Digital Intermediate |
| Dave Muscat | Digital Intermediate |
| Warren Appleby | Special Effects Coordinator |
| Richard Berube | Electrician |
| Stephanie Lees | Assistant Costume Designer |
| Jonathan McHugh | Music Supervisor |
| Tavia Charlton | Digital Intermediate |
| Tom Mayclim | Negative Cutter |
| Greg Copeland | Production Manager |
| Greg Copeland | Co-Producer |
| Troy Begnaud | Associate Producer |
| Alison Reid | Stunt Coordinator |
| Jane Rogers | Extras Casting |
| Shawn Stewart | Stunt Double |
| Billy Oliver | Stunt Double |
| Neil Davison | Stunt Double |
| Marco Bianco | Stunt Double |
| Leigh Whannell | Original Film Writer |
| James Wan | Original Film Writer |
