 | Yoshimasa Hosoya als John H. Watson (voice) |
 | Ayumu Murase als Friday (voice) |
 | Akio Otsuka als M (voice) |
 | Takayuki Sugo als The One (voice) |
 | Taiten Kusunoki als Frederick Barnaby (voice) |
 | Kana Hanazawa als Hadaly Lilith (voice) |
 | Shin-ichiro Miki als Alexei Karamazov (voice) |
 | Daiki Yamashita als Nikolai Krasotkin (voice) |
 | Jiro Saito als Seigo Yamazawa (voice) |
 | Koji Ishii als Ulysses Grant (voice) |
 | Houko Kuwashima als Moneypenny (voice) |
 | Kouji Takeda als Thomas Edison (voice) |
 | Yoshimitsu Takasugi als Sherlock Holmes (voice) |
 | Issei Futamata als Narrator (voice) |
| Shoji Hata | Sound Director |
| Ryotaro Makihara | Director |
| Koji Yamamoto | Screenplay |
| Keiji Ota | Executive Producer |
| Satoshi Itō | Novel |
| Hirotaka Kato | Supervising Animation Director |
| Hirotaka Kato | Key Animation |
| Yoshihiro Ike | Original Music Composer |
| Koji Yamamoto | Executive Producer |
| Yoko Matsuzaki | Executive Producer |
| Midori Goto | Screenplay |
| Takaaki Chiba | Character Designer |
| Eri Osada | Key Animation |
| Toh EnJoe | Novel |
| Hiroshi Seko | Screenplay |
| Takaaki Chiba | Supervising Animation Director |
| Manabu Kamino | Online Editor |
| Ryotaro Makihara | Storyboard Artist |
| Kumiko Kawana | Animation Director |
| Kumiko Kawana | Key Animation |
| Chiaki Nishinaka | Production Assistant |
| Koji Tanaka | Director of Photography |
| Hirofumi Masuda | Key Animation |
| Nobutake Ito | Key Animation |
| Takahiro Chiba | Key Animation |
| Yoshimichi Kameda | Key Animation |
| Naoki Tate | Key Animation |
| Atsuko Nozaki | Key Animation |
| redjuice | Character Designer |
| Yuumi Kawai | Assistant Production Manager |
| Hitomi Haga | Background Designer |
| Katsu Nozaki | Background Designer |
| Yusuke Takeda | Art Direction |
| Tsukasa Kakizakai | Art Designer |
| Yoshinori Shiozawa | Art Designer |
| Tomoyuki Aoki | Art Designer |
| Yukie Inose | Art Designer |
| Takeshi Takahashi | Art Designer |
