 | Dwayne Johnson als Boxer Santaros / Jericho Cane |
 | Seann William Scott als Roland Taverner / Ronald Taverner |
 | Sarah Michelle Gellar als Krysta Kapowski / Krysta Now |
 | Justin Timberlake als Private Pilot Abilene |
 | Mandy Moore als Madeline Frost-Santaros |
 | Will Sasso als Fortunio Balducci |
 | Jon Lovitz als Bart Bookman |
 | Beth Grant als Dr. Inga Von Westphalen |
 | Jill Ritchie als Shoshana Kapowski |
 | Bai Ling als Serpentine |
 | Lisa K. Wyatt als Teri Riley |
 | Curtis Armstrong als Dr. Soberin Exx |
 | Todd Berger als Bing Zinneman |
 | Rebekah Del Rio als Vanessa Vera Cruz |
 | Nora Dunn als Cyndi Pinziki |
 | Christophe Lambert als Walter Mung |
 | John Larroquette als Vaughn Smallhouse |
 | Janeane Garofalo als General Teena MacArthur |
 | Abbey DiGregorio als Sheena Gee |
 | Cheri Oteri als Zora Charmichaels |
 | Amy Poehler als Veronica Mung / Dream |
 | Miranda Richardson als Nana Mae Frost |
 | Wallace Shawn als Baron Von Westphalen |
 | Sab Shimono als Hideo Takehashi |
 | Kevin Smith als Simon Theory |
 | Robert Benz als Tab Taverner |
| Joe Campana als Brandt Huntington |
| Chris Andrew Ciulla als UPU 4 Officer 3 |
| Aaron Dillar als Jimmy Hermosa |
| Shari Dunn als USI Dent Reporter |
| Michele Durrett als Starla Von Luft |
| Jon Falcone als Soldier Falcon |
| Jaret Gardiner als Shane Laverne |
 | Wood Harris als Dion Element |
 | Shannon Lee Holmes als Todd Zinneman |
 | Katherine Kendall als Megazeppelin Waitress |
| Jinah Kim als Dr. Linda Lao |
| Gianna Luchini als Deena Storm |
| Mike Nielsen als Kenny Chan |
 | Holmes Osborne als Senator Bobby Frost |
 | Lou Taylor Pucci als Martin Kefauver |
| Kevin Robertson als Seamus Storm |
 | Zelda Rubinstein als Dr. Katarina Kuntzler |
| Philip Sternberg als Dennis Voogler |
 | Sarah Christine Smith als Dancer #1 |
| Nicole Sciacca als Dancer #2 |
| Aliane Baquerot als Dancer #3 |
 | Becca Sweitzer als Dancer #4 |
| Chi Johnson als Dancer #5 |
| Jenna Stewart als Dancer #6 |
 | Rachael Markarian als Dancer #7 |
 | Marcy McCusker als Dancer #8 |
| Dave Carlin als News Reporter |
 | Katarina Hyde als Isabella / Interpreter |
 | Sharon Jordan als Secretary |
| Sean LoGrasso als US Ident Worker |
 | Paulah May als Hysterical Passenger |
 | Matt McColm als Bar Bouncer |
| John T. O'Brien als SWAT Team Officer |
| Philip Roosevelt als Homeless Terrorist |
 | Eli Roth als Man Who Gets Shot on Toilet |
 | Gary Sievers als Homeless Terrorist |
| Richard Kelly | Director |
| Bo Hyde | Producer |
| Sean McKittrick | Producer |
| Kendall Morgan | Producer |
| Matthew Rhodes | Producer |
| Moby | Original Music Composer |
| Steven Poster | Director of Photography |
| Sam Bauer | Editor |
| Venus Kanani | Casting |
| Mary Vernieu | Casting |
| Alec Hammond | Production Design |
| Tracey A. Doyle | Art Direction |
| April Ferry | Costume Design |
| Priscilla Elliott | Assistant Art Director |
| Edward H. Hamm Jr. | Executive Producer |
| Oliver Hengst | Executive Producer |
| Katarina Hyde | Executive Producer |
| Bill Johnson | Executive Producer |
| Kevin Loughery | Executive Producer |
| Judd Payne | Executive Producer |
| Wolfgang Schamburg | Associate Producer |
| Ernst-August Schnieder | Associate Producer |
| Jim Seibel | Executive Producer |
| Dara Weintraub | Co-Producer |
| Tim Pedegana | Post Production Supervisor |
| Christa Vausbinder | Production Supervisor |
| Dara Weintraub | Unit Production Manager |
| Victor James Martinez | Set Designer |
| Sam Page | Set Designer |
| J.C. Cantu | Casting Assistant |
| Shalimar Reodica | Casting Associate |
| Ralph B. Meyer | Location Manager |
| Maxine Bergen | Script Supervisor |
| Kelly Carlton | Title Designer |
| Sara Scarritt | Production Coordinator |
| Anna Fleiner | Makeup Artist |
| Louis Lazzara | Makeup Department Head |
| Ermahn Ospina | Makeup Artist |
| Eric Rood | Set Dresser |
| Benton E. Tedlie | Set Dresser |
| Chris David | Sound Re-Recording Mixer |
| Christopher Eakins | Sound Editor |
| David Esparza | Supervising Sound Editor |
| David Esparza | Sound Designer |
| Marshall Garlington | Sound Re-Recording Mixer |
| Stuart Provine | Sound Effects Editor |
| Steve Schatz | Sound Editor |
| Lisa Varetakis | Foley Editor |
| Mandell Winter | Foley Editor |
| Jenny Foster | Visual Effects Producer |
| Danny S. Kim | Visual Effects Supervisor |
| Olcun Tan | Visual Effects Supervisor |
| Thomas Tannenberger | Visual Effects Supervisor |
| Sherman Toy | Visual Effects Supervisor |
| Donna Marcione Pollack | Costume Supervisor |
| Richard Kelly | Writer |
| Veronica Lorenz | Makeup Artist |
| Ron Cobb | Production Design |
| David DeLeon | Key Makeup Artist |
| Laura Connolly | Key Hair Stylist |
| Danielle Noe | Special Effects Makeup Artist |
| Laverne Caracuzzi | Makeup Artist |
| Mark Cotone | First Assistant Director |
| Al Goto | Stunts |
| Tanoai Reed | Stunt Coordinator |
| Tim Trella | Stunt Coordinator |
| Anita Hart | Stunt Double |
| Shawn Robinson | Stunts |
| Chris Palermo | Stunts |
| Rex Reddick | Stunts |
| Alisa Hensley | Stunts |
| Shawn Patrick Lane | Stunts |
| Edward Conna | Stunts |
| Hank Amos | Stunts |
| Kenny Alexander | Stunts |
| Brian Avery | Stunts |
| Wendi Bromley | Stunts |
| Debbie Evans | Stunts |
| Tom Elliott | Stunts |
| Michael Gilden | Stunts |
| Darin Fujimori | Stunts |
| Mike Justus | Stunts |
| James M. Halty | Stunts |
| Dennis Keiffer | Stunts |
| Lane Leavitt | Stunts |
| Luke LaFontaine | Stunts |
| Matt McColm | Stunts |
| Angela Meryl | Stunts |
| John C. Meier | Stunts |
| Troy Robinson | Stunts |
| Christopher J. Tuck | Stunts |
| Scott Workman | Stunts |
| Danny Wynands | Stunts |
| Joanna Shelmidine | Stunt Double |
| Tracey A. Doyle | Set Decoration |
| Joy Zapata | Hair Department Head |
| Christian Beckman | Special Effects Makeup Artist |
| Eli Roth | Thanks |
| Michael Runyard | Stunts |
| Doc Duhame | Stunts |
| Norm Compton | Stunts |
| Mic Rodgers | Stunts |
| Suzanne Reed | Stunts |
| Dakota Mitchell | Stunts |
| Jesse Jam Miranda | Stunts |
| Stuart F. Wilson | Stunts |
| Paul M. Lane | Utility Stunts |
| Boni Yanagisawa | Stunts |
| Thom Williams | Stunts |
| James Ryan | Stunts |
| Marguerite Pomerhn Derricks | Choreographer |
| Tim Trella | Second Unit Director |
| Kevin Turen | Thanks |
| Eliott Taylor | ADR Recordist |
