 | George Clooney als Bob Barnes |
 | Matt Damon als Bryan Woodman |
 | Jeffrey Wright als Bennett Holiday |
 | Chris Cooper als Jimmy Pope |
 | Amanda Peet als Julie Woodman |
 | William Hurt als Stan |
 | Christopher Plummer als Dean Whiting |
 | Alexander Siddig als Prince Nasir Al-Subaai |
 | Kayvan Novak als Arash |
 | Amr Waked als Mohammed Sheik Agiza |
 | Robert Foxworth als Tommy Barton |
 | Nicky Henson als Sydney Hewitt |
 | Nicholas Art als Riley Woodman |
 | Steven Hinkle als Max Woodman |
 | Daisy Tormé als Rebecca |
 | Peter Gerety als Leland "Lee" Janus |
 | Richard Lintern als Bryan's Boss |
| Mazhar Munir als Wasim Khan |
 | Jocelyn Quivrin als Vincent |
 | Shahid Ahmed als Saleem Ahmed Khan |
| Bikram Singh Bhamra als Pakistani Translator |
 | Roger Yuan als Chinese Engineer |
 | Jamey Sheridan als Division Chief |
 | Randall Boffman als Distinguished Gentleman #1 |
 | Max Minghella als Robby Barnes |
 | Nadim Sawalha als Emir Hamed Al-Subaai |
 | Akbar Kurtha als Prince Meshal Al-Subaai |
| Sonnell Dadral als Farooq |
 | Tim Blake Nelson als Danny Dalton |
 | Mark Strong als Mussawi |
| Badria Timimi als Nasir's Wife |
 | Viola Davis als CIA Chairwoman |
 | Ozzie Yue als Chinese Oil Executive |
 | Donna Mitchell als Pat Janus |
 | David Clennon als Donald |
| Susan Allenback als Paralegal #1 |
| Katherine Hoskins Mackey als Paralegal |
| Linda E. Williams als Paralegal |
 | Susan Duvall als Assistant at CIA |
 | Bahar Soomekh als Yassi (uncredited) |
| Susan Halsey Singer als Mother (uncredited) |
| Elena Rosa als CIA Operations Specialist (uncredited) |
| Lauren Minite als Restaurant Girl (uncredited) |
 | Anna George als Reza's Sister (uncredited) |
| Wendy Kush als Witness (uncredited) |
| Mike Monroe als Lawyer (uncredited) |
| Dan Weil | Production Design |
| Robert Elswit | Director of Photography |
| Tim Squyres | Editor |
| Jennifer Fox | Producer |
| Lora Kennedy | Casting |
| Stephen Gaghan | Screenplay |
| Estelle Crottaz | Casting |
| Avy Kaufman | Casting |
| Alexandre Desplat | Original Music Composer |
| Lucinda Syson | Casting |
| Stephen Gaghan | Director |
| Georgia Kacandes | Producer |
| Michael Nozik | Producer |
| Robert Baer | Book |
| John Casey | Costume Supervisor |
| Waldo Sanchez | Hairstylist |
| Kay Georgiou | Hairstylist |
| Christine Beveridge | Makeup Department Head |
| Marilyn MacDonald | Makeup Artist |
| Barry R. Koper | Makeup Artist |
| Jana Chovancova | Art Department Coordinator |
| Louise Frogley | Costume Design |
| Mary Cybulski | Script Supervisor |
| Jeff Skoll | Executive Producer |
| Elizabeth Kirk | Associate Producer |
| Ben Cosgrove | Executive Producer |
| Steve Dent | Stunt Coordinator |
| Olivia Bloch-Lainé | Set Decoration |
| Eric Durst | Visual Effects Supervisor |
| Nick Vidar | Music Editor |
| Larry Blake | Sound Re-Recording Mixer |
| Shannon Lail | Associate Producer |
| Glen Wilson | Still Photographer |
| Colin Anderson | Camera Operator |
| Steven Soderbergh | Executive Producer |
| Sarah Bradshaw | Associate Producer |
| Ken Regan | Still Photographer |
| Vanessa Lapato | Sound Editor |
| Jeena M. Phelps | Sound Editor |
| Jeff Sawyer | Sound Editor |
| Sidney Ray Baldwin | Still Photographer |
| Larry Blake | Supervising Sound Editor |
| François Duhamel | Still Photographer |
| Colin Anderson | Steadicam Operator |
| Petur Hliddal | Sound mixer |
| Julie Feiner | Sound Editor |
| Jan Pascale | Set Decoration |
| George Clooney | Executive Producer |
| Patrick Tendai Pfupajena | Production Assistant |
| Jasmine Yuen Carrucan | Second Assistant "A" Camera |
| Will Dearborn | Second Assistant "A" Camera |
| Barry Idoine | First Assistant "A" Camera |
| Gregor Tavenner | First Assistant "B" Camera |
| David R. Morton | VFX Artist |
| Alan Hook | Art Direction |
