 | Julianne Moore als Telly Paretta |
 | Dominic West als Ash Correll |
 | Gary Sinise als Dr. Munce |
 | Anthony Edwards als Jim Paretta |
 | Alfre Woodard als Det. Anne Pope |
 | Linus Roache als A Friendly Man |
 | Robert Wisdom als Carl Dayton |
 | Jessica Hecht als Eliot |
 | Christopher Kovaleski als Sam |
 | Matthew Pleszewicz als Sam at 5 |
| Katie Cooper als Library Clerk |
 | Scott Nicholson als Cop |
| P.J. Morrison als Cop |
 | Tim Kang als Agent Alec Wong |
| Kathryn Faughnan als Lauren Correll |
 | Felix Solis als Brasher |
 | Susan Misner als Agent Lisa Franks |
 | Lee Tergesen als Al Petalis |
| Ken Abraham als Gas Station Attendant |
 | J. Tucker Smith als Sheriff Howell |
 | Ann Dowd als Eileen the Accountant |
 | Brielle Barbusca als Child Walking with Mother (uncredited) |
 | Dono Cunningham als Warehouse Worker (uncredited) |
| Kathrina Miccio als Mrs. Munce (uncredited) |
 | Frank Stellato als NSA Agent (uncredited) |
| Zoë Raye als Additional Voices (voice) (uncredited) |
| Joseph Ruben | Director |
| James Horner | Original Music Composer |
| Bruce Cohen | Producer |
| Gerald Di Pego | Screenplay |
| Dan Jinks | Producer |
| Richard Francis-Bruce | Editor |
| Joe Roth | Producer |
| Anastas N. Michos | Director of Photography |
| Margery Simkin | Casting |
| Cindy Evans | Costume Design |
| Raymond M. Samitz | Construction Coordinator |
| John Roesch | Foley |
| Steven Kirshoff | Special Effects Coordinator |
| Susan Bode Tyson | Set Decoration |
| Alan D'Angerio | Hairstylist |
| Myron Nettinga | Sound Re-Recording Mixer |
| Fred Kraemer | Special Effects Coordinator |
| Elaine L. Offers | Makeup Artist |
| Dick Tice | Leadman |
| Krzysztof J. Bratun | Scenic Artist |
| David Boyd | Scenic Artist |
| Dane A. Davis | Supervising Sound Editor |
| Eric Lindemann | Sound Effects Editor |
| Lyndell Quiyou | Hairstylist |
| Amy Safhay | Greensman |
| Lauren Buckley | Art Department Coordinator |
| Miguel López-Castillo | Set Designer |
| Dane A. Davis | Sound Designer |
| Margot Boccia | Makeup Artist |
| Benjamin Robin | Makeup Artist |
| Paul D. Kelly | Art Direction |
| Michael Minkler | Sound Re-Recording Mixer |
| Alyson Dee Moore | Foley |
| Bill Groom | Production Design |
| Guy T. Wiedmann | Visual Effects Editor |
| Carey Villegas | Visual Effects Supervisor |
| Matthew Gratzner | Visual Effects Supervisor |
| Dane Clarke | Camera Operator |
| Ramiro Belgardt | Music Editor |
| Joe E. Rand | Music Editor |
| Kathy Orloff | Unit Publicist |
| Matthew Hendershot | CG Supervisor |
| Hans Bjerno | Helicopter Camera |
| David Taritero | Visual Effects Producer |
| Jonathan Rothbart | Visual Effects Supervisor |
| David S. Dranitzke | Visual Effects Producer |
| Terry Leonard | Stunt Coordinator |
| Lyn Pinezich | Location Manager |
| Will Arnot | Steadicam Operator |
| Nathan R. Fitzgerald | Digital Intermediate |
| Jennifer Spenelli | First Assistant Editor |
| Garrett Brown | Camera Operator |
| Charlie Grubbs | Rigging Gaffer |
| Marta Font | Set Costumer |
| Barry Wetcher | Still Photographer |
| Joan Puma | Script Supervisor |
| Andy Day | Gaffer |
| Mary Beth Worzella | Visual Effects Producer |
| Daniel Moder | Camera Operator |
| Peter Masterson | Camera Operator |
| Craig Mann | Sound Recordist |
| David M. Dunlap | Second Unit Director of Photography |
| David Gulick | Property Master |
| Michael Barosky | Sound Mixer |
| Stephanie Flack | Supervising Dialogue Editor |
| Eddie Bydalek | Sound Recordist |
| Tina Mckissick | Stunts |
| Kym Washington Longino | Stunts |
| John Copeman | Stunts |
| Jodi Michelle Pynn | Stunts |
| Al Cerullo | Stunts |
| David Shumbris | Stunts |
| Aaron Walters | Stunts |
| John Cenatiempo | Stunts |
| Chris Cenatiempo | Stunts |
| Janet Paparazzo | Stunts |
| Cinda-Lin James | Stunts |
| Pat Romano | Stunts |
| Andy Gill | Stunts |
| Danny Aiello III | Stunts |
| Steve Nicolaides | Executive Producer |
| Todd Garner | Executive Producer |
| Bill Anagnos | Stunts |
| Chuck Zito | Stunts |
| Doug Snively | Stunts |
| Angela Meryl | Stunts |
| Peter Epstein | Stunts |
| Victor Chan | Stunts |
| Tony Guida | Stunts |
| Gino Lucci | Stunts |
| Ralph Ferrara | Stunts |
| Frank Ferrara | Stunts |
| Andrew Dupin | Stunts |
| Paul Bucossi | Stunts |
| Terry Leonard | Second Unit Director |
