 | Ryan Reynolds als Jerry Hickfang / Mr. Whiskers (voice) / Bosco (voice) / Deer (voice) / Bunny Monkey (voice) |
 | Gemma Arterton als Fiona |
 | Anna Kendrick als Lisa |
 | Jacki Weaver als Dr. Warren |
 | Ella Smith als Alison |
 | Paul Chahidi als Dennis Kowalski |
 | Stanley Townsend als Sheriff Weinbacher |
 | Adi Shankar als John |
 | Sam Spruell als Dave |
 | Valerie Koch als Jerry's Mother |
 | Gulliver McGrath als Jerry (12 years old) |
 | Paul Brightwell als Jerry's Stepfather |
 | Alessa Kordeck als Sheryl |
 | Michael Pink als Jesus |
 | Ricardia Bramley als Sheila Hammer |
 | Alex Tondowski als Tom |
| Marjane Satrapi | Director |
| Maxime Alexandre | Director of Photography |
| Stéphane Roche | Editor |
| Udo Kramer | Production Design |
| Bettina Helmi | Costume Design |
| Roy Lee | Producer |
| Michael R. Perry | Writer |
| Matthew Rhodes | Producer |
| Adi Shankar | Producer |
| Spencer Silna | Producer |
| Nicole Barton | Co-Producer |
| Alex Foster | Co-Producer |
| Marco Mehlitz | Co-Producer |
| Thomas Nickel | Co-Producer |
| Mathias Schwerbrock | Line Producer |
| Christoph Fisser | Executive Producer |
| John Powers Middleton | Executive Producer |
| Henning Molfenter | Executive Producer |
| Elika Portnoy | Executive Producer |
| Douglas Saylor Jr. | Executive Producer |
| Cathy Schulman | Executive Producer |
| Adam C. Stone | Executive Producer |
| Olivier Bernet | Original Music Composer |
| Charlie Woebcken | Executive Producer |
| Larry Blake | ADR Mixer |
| Nathalie Tissier | Key Makeup Artist |
| Nathalie Tissier | Makeup Designer |
