 | Oakes Fegley als Ben |
 | Millicent Simmonds als Rose |
 | Julianne Moore als Lillian Mayhew / Rose |
 | Michelle Williams als Elaine |
 | Cory Michael Smith als Walter |
 | James Urbaniak als Dr. Kincaid, Rose's Father |
 | Damian Young als Otto, Museum Guard |
 | Patrick Murney als Workman |
 | Lauren Ridloff als Pearl, The Maid |
 | Anthony Natale als Dr. Gill, Teacher of the Deaf |
 | Carole Addabbo als Miss Conrad at the Museum |
| Howard Seago als Remy Rubin, Theater Director |
 | Brian Berrebbi als Stage Manager |
 | John P. McGinty als Valentin |
| Mark A. Keeton als Shopkeeper |
| Patrick Wiley als Window Dresser |
 | Garrett Zuercher als Officer Engel |
 | Jared Johnston als Officer Murtha |
 | Murphy Guyer als Security Chief |
 | Ekaterina Samsonov als Hannah |
 | Sawyer Niehaus als Blessing |
| Lilianne Rojek als Florence |
| Michael W. Gaines als Butler |
 | Jaden Michael als Jamie |
 | Tom Noonan als Walter |
 | Morgan Turner als Janet |
 | Amy Hargreaves als Aunt Jenny |
 | Sawyer Nunes als Robbie |
 | Raul Torres als Jamie's Father |
 | Mandela Bellamy als Woman on Bus |
 | Jim Lavin als ER Doctor |
| Colleen Cosgrove als ER Nurse |
 | Hays Wellford als Greg Coons at the Bus Stop |
| Asa Liebmann als Thief |
 | John Boyd als Danny |
| Oladamolami Adisa als Signing Hands |
| Mylo Barrett als Signing Hands |
| Robinho Cruz als Signing Hands |
| Vanessa DeLeon als Signing Hands |
| Jordana Lurman als Signing Hands |
| Tom Waters als 1970's Business Man (uncredited) |
| Connor Moeller als Museum Boy (uncredited) |
| Mackenzie Grace Castle als Museum Girl (uncredited) |
 | Derek Chadwick als Liam (uncredited) |
| Logan Taylor als Promenade Child / Museum Child (uncredited) |
| Edward Lachman | Director of Photography |
| Todd Haynes | Director |
| Brian Selznick | Writer |
| Brian Selznick | Novel |
| Paul Molnar | Makeup Artist |
| Suzy Mazzarese-Allison | Hairstylist |
| Leann Murphy | Art Department Coordinator |
| Drew Kunin | Sound Mixer |
| Wesley Petersen | Transportation Captain |
| Kim Jennings | Art Direction |
| Stephen Barth | Scenic Artist |
| Eric Fehlberg | Conceptual Illustrator |
| Tina Khayat | Set Decorating Coordinator |
| Michael Gallart | Rigging Gaffer |
| Michael A. Leo | Lighting Technician |
| Kim Ostroy | Casting Assistant |
| Kathi Scharer | Production Accountant |
| Sandy Powell | Costume Design |
| Jim Lillis | Set Dresser |
| Roxanne Roca | Stunts |
| Laura Rosenthal | Casting |
| Nathaniel Davis | Set Dresser |
| Roman Greller | Set Dresser |
| Joe Taglairino | Set Dresser |
| Debra Schutt | Set Decoration |
| Timothy Bird | First Assistant Director |
| Patrick Wiley | Assistant Costume Designer |
| Frank Murray | Co-Producer |
| Patricia Regan | Makeup Department Head |
| Tomasina Smith | Makeup Artist |
| Brian Bell | Unit Production Manager |
| John M. Souto | Set Dresser |
| Joel Weaver | Assistant Property Master |
| Todd Kasow | Music Editor |
| Pamela Koffler | Producer |
| Jerry DeCarlo | Hair Department Head |
| James McMillan | Second Unit Director of Photography |
| David Davenport | Costume Supervisor |
| Amanda Dudzinski | Post Production Assistant |
| Warwick Hewett | Visual Effects Producer |
| Timothy Healy | Electrician |
| Brian Bell | Executive Producer |
| Christine Vachon | Producer |
| Ryan Heck | Art Direction |
| Eric Lewis Beauzay | Assistant Art Director |
| Brad Goss | Key Grip |
| Anna Elizabeth Ritter | Post Production Assistant |
| John Sloss | Producer |
| Katya Blumenberg | Assistant Art Director |
| Rumiko Ishii | Assistant Art Director |
| Jeffrey D. McDonald | Assistant Art Director |
| Mary Bailey | Script Supervisor |
| Gary Martyn | Production Coordinator |
| Mark Friedberg | Production Design |
| Christopher Kay | Scenic Artist |
| Maribeth Fox | Casting Associate |
| Theresa Bradley | Set Medic |
| Gary Martori | Hairstylist |
| Marc Connor | Scenic Artist |
| Erica Hohf | Assistant Art Director |
| Lionel Jacobs | Digital Compositors |
| Matthew Kania | Location Manager |
| Dan Decelle | Set Dresser |
| Sandy Hamilton | Property Master |
| Timothy Metzger | Leadman |
| Diane Rich | Scenic Artist |
| Vicky Daneau | VFX Editor |
| Michael Auszura | Assistant Art Director |
| David Swayze | Conceptual Illustrator |
| Chad Strohmayer | Electrician |
| Susan Antonelli | Set Costumer |
| Rich Moody | Assistant Production Coordinator |
| Affonso Gonçalves | Editor |
| Monique Benoit | Makeup Artist |
| Hugh Sicotte | Conceptual Illustrator |
| Nhu-Anh Le | Costume Coordinator |
| Carter Burwell | Music |
| Candis Heiland | Set Dresser |
| Bob Calandro | Grip |
| Jodi Angstreich | Casting Associate |
| Lara Greene | Tailor |
| Daniel Ward | Sound Effects Editor |
| Avi Laniado | Sound Engineer |
| Brian Adler | Visual Effects |
| Joseph S. Alfieri | Construction Coordinator |
| Keith Stiegelbauer | Set Dresser |
| Marie-France Henri | Rotoscoping Artist |
| Mark Friedberg | Second Unit Director |
| Marlene McCarty | Title Designer |
