 | Jake Gyllenhaal als Donnie Darko |
 | Jena Malone als Gretchen Ross |
 | James Duval als Frank |
 | Drew Barrymore als Karen Pomeroy |
 | Beth Grant als Kitty Farmer |
 | Maggie Gyllenhaal als Elizabeth Darko |
 | Mary McDonnell als Mrs. Rose Darko |
 | Holmes Osborne als Eddie Darko |
 | Noah Wyle als Prof. Kenneth Monnitoff |
 | Katharine Ross als Dr. Lilian Thurman |
 | Patrick Swayze als Jim Cunningham |
 | Daveigh Chase als Samantha Darko |
 | Arthur Taxier als Dr. Fisher |
 | David St. James als Bob Garland |
 | Patience Cleveland als Roberta Sparrow / Grandma Death |
 | Jazzie Mahannah als Joanie James |
 | Jolene Purdy als Cherita Chen |
 | David Moreland als Principal Cole |
| Kristina Malota als Susie Bates |
| Marina Malota als Emily Bates |
 | Scotty Leavenworth als David |
 | Phyllis Lyons als Anne Fisher |
| Gary Lundy als Sean Smith |
 | Alex Greenwald als Seth Devlin |
 | Stuart Stone als Ronald Fisher |
 | Joan Blair als Mystery Woman |
 | Seth Rogen als Ricky Danforth |
| Mark Hoffman als Police Officer |
 | Jerry Trainor als Lanky Kid |
| Tom Tangen als Man in Red Jogging Suit |
| Carly Naples als Suzy Bailey |
 | Lisa K. Wyatt als Linda Connie |
 | Rachel Winfree als Shanda Riesman |
 | Ashley Tisdale als Kim |
 | Tiler Peck als Beth Farmer |
 | Fran Kranz als Passanger |
 | Sarah Hudson als Friend |
| Alison Jones als Dorky Half-Sister |
 | Lee Weaver als Leroy |
 | Jack Salvatore, Jr. als Larry Riesman |
| Aaron Ryder | Executive Producer |
| Richard Kelly | Screenplay |
| Richard Kelly | Director |
| Adam Fields | Producer |
| Sean McKittrick | Producer |
| Nancy Juvonen | Producer |
| Michael Andrews | Original Music Composer |
| Steven Poster | Director of Photography |
| Sam Bauer | Editor |
| Eric Strand | Editor |
| Joseph Middleton | Casting |
| Michelle Morris | Casting |
| Jennifer Barak | Music Editor |
| Michael Payne | Sound Designer |
| Drew Barrymore | Executive Producer |
| April Ferry | Costume Design |
| Donna Berwick | Assistant Costume Designer |
| Dan Bradley | Stunts |
| Alec Hammond | Production Design |
| Victoria Rose Sampson | Dialogue Editor |
| Victoria Rose Sampson | ADR Editor |
| Hunt Lowry | Executive Producer |
| Richard Crudo | Camera Operator |
| Christopher Ball | Executive Producer |
| William Tyrer | Executive Producer |
| Richard L. Fox | First Assistant Director |
| Heather Grierson | Second Assistant Director |
| Casey La Scala | Executive Producer |
| Steve Gainer | Camera Operator |
| Dan Lynch | Grip |
| David Chameides | Steadicam Operator |
| Coleman Metts | Production Sound Mixer |
| Dale Robinette | Still Photographer |
| Kimberly Greene | Makeup Artist |
| Jeff Higinbotham | Set Dresser |
| Michael Scott | Camera Operator |
| Mickey Giacomazzi | Stunt Coordinator |
| Lex Rawlins | First Assistant Camera |
| Sean Graham | Stunts |
| Jeff Zucker | Gaffer |
| Nancy Tracy | Dialogue Editor |
| Nancy Tracy | ADR Editor |
| Rebecca Asher | Script Supervisor |
| Richard Bloom | Art Department Coordinator |
| Julia K. Levine | Set Designer |
| Geno Hart | Transportation Coordinator |
| Lori McCoy-Bell | Hair Department Head |
| Thomas Hayslip | Line Producer |
| Jamie Maheu | Set Dresser |
| Bing Sokolsky | Camera Operator |
| Michael Ballew | Driver |
| Mark Anderson | Property Master |
| Lynn Barber | Makeup Department Head |
| Manish Raval | Music Supervisor |
| Tom Wolfe | Music Supervisor |
| Jennie Harris | Set Decoration |
| Joseph Markham | Costume Supervisor |
| Kim Percival | Production Coordinator |
| Kirk Huston | Transportation Captain |
| Spencer Wilcox | Grip |
| Billy Kane | Driver |
| Victor Svimonoff | Best Boy Electric |
| Dena Berman | Casting Assistant |
| Robin Lynn Bonaccorsi | Stunts |
| Shawn Kennelly | Foley Mixer |
| Gregory Diggins | Propmaker |
| Waide R. Allen | Electrician |
| Larry Pausback | Grip |
| Mike Reiber | Painter |
| Bob Fisher | Boom Operator |
| Richard Epper | Grip |
| Casey Mako | Second Second Assistant Director |
| Larissa Supplitt | Second Assistant Camera |
| Brian Rosso | Grip |
| Joel Jaspan | Grip |
| Hugh Aodh O'Brien | Stunts |
| William D. Wynn | Dolly Grip |
| Thomas Gibson | Painter |
| David L. Merrill | Key Grip |
| Andrew Garcia-Price | Storyboard Artist |
| Mark Morton | Best Boy Electric |
| Nisa Kellner | Costumer |
| Chris Byers | Grip |
| Mike Curtis | Electrician |
| Travis Panarisi | Electrician |
| Ignacio Woolfolk | Grip |
| Jim Chase | Grip |
| Dick Montagne | Camera Operator |
| Fritz Weber | Grip |
| John Keefer | Grip |
| Dan Scolnik | Foley Editor |
| Kevin Cook | Grip |
| Edward Tamayo | Set Dresser |
| Denise Anderson | Assistant Property Master |
| Knut Kielpinski | Driver |
| Curtis Clark | Driver |
| Michael Stewart Maahs | Grip |
| Debe Waisman | Extras Casting |
| Norman Edward Parker | First Assistant Camera |
| Michelle R. Belair | Propmaker |
| Andrew Berentis | Propmaker |
| Jonathan Bernardi | Propmaker |
| Christopher Cuneo | Propmaker |
| Dino Doane | Propmaker |
| Tim Durrell | Propmaker |
| Patrick Foyle | Propmaker |
| Gregg Hager | Propmaker |
| Ted Harms | Propmaker |
| Terry Lasko | Propmaker |
| Christian E. Lemer | Propmaker |
| Mark Mastropietro | Propmaker |
| Alejandro Poli | Propmaker |
| Ed Sher | Painter |
| J.R. Vasquez | Leadman |
| Scott Vollmer | Propmaker |
| Jeanna Marie Phillips | Stunts |
| Phil Aubrey | Grip |
| Klint Betz | Best Boy Grip |
| Pierre Cane | Electrician |
| Keith Chadwick | Grip |
| Briewen Corry | Grip |
| Steve Franklin | Grip |
| Coby Garfield | Second Assistant Camera |
| Dale Gladish | Grip |
| Bernie Horn-Bostel | Best Boy Grip |
| Derek Page | Electrician |
| Dustin Woods | Grip |
| David Ferry | Costumer |
| Lyle Atkins | Driver |
| Lynda Dedmon | Driver |
| Jennifer Duclos | Driver |
| Audrey Fitzgerald | Driver |
| Dennis Germain | Driver |
| Frank Graves | Driver |
| Jackson Iblings | Driver |
| Roger Ickes | Driver |
| Alfie Jensen | Driver |
| Rocco Mann | Driver |
| Steve Maytum | Driver |
| Hardy Ophuls | Picture Car Coordinator |
| Anthony J. Mignano | Driver |
| Joe Moreno | Driver |
| Marcus Keys | Visual Effects Supervisor |
