 | Shia LaBeouf als Jerry Shaw |
 | Michelle Monaghan als Rachel Holloman |
 | Rosario Dawson als Zoe Perez |
 | Michael Chiklis als Defense Secretary Callister |
 | Anthony Mackie als William Bowman |
 | Ethan Embry als Toby Grant |
 | Billy Bob Thornton als Thomas Morgan |
 | Anthony Azizi als Ranim Khalid |
 | Cameron Boyce als Sam Holloman |
 | Lynn Cohen als Mrs. Wierzbowski |
 | Bill Smitrovich als Admiral Thompson |
 | Charles Carroll als Mr. Miller |
 | William Sadler als Jerry's Dad |
 | Deborah Strang als Jerry's Mom |
 | Dariush Kashani als Translator |
 | Bob Morrisey als Director of Intelligence |
| J. Patrick McCormack als Pentagon General Council |
| Lorenzo Eduardo als Kwame |
 | Madylin Sweeten als Becky |
 | Jorge-Luis Pallo als Intel Officer |
 | James Huang als Intel Officer |
 | Gerald Downey als Console Tech |
 | Tony Flores als Team Leader |
 | Donnie Jeffcoat als FBI Agent |
 | Craig J. Harris als Man on Train |
| Jimmie L. Akins als Transit Cop on Train |
 | Eric Christian Olsen als Craig |
 | Marc Singer als Explosives Developer |
 | Michael Maize als Master Sergeant |
 | Eiko Nijo als Masako Tour Guide |
| Peter Gail als PFPA Officer |
 | Brad Grunberg als Circuit City Salesperson |
 | Cylk Cozart als Sectran Courier |
 | Manny Perry als Sectran Courier |
| James C. Gohrick als Agent in Alley |
 | Josh Todd als Convenience Store Clerk |
 | Colby French als Console Tech |
 | Matt DeCaro als Stranger at Airport |
 | Judith Moreland als Security Attendant at Airport |
 | Rolando Molina als TSA Agent |
 | Michael Kostroff als Jeweler |
 | Nigel Gibbs als Callister Aide |
 | Michael Daniel Cassady als White House Staffer |
 | David Grant Wright als Secret Service Agent #1 |
 | Jarod Einsohn als Reaper Control Tech |
| David Heckel als Squadron Commander |
 | Jamie Martz als Northcom Control Tech |
 | Greg Collins als Two Star General |
 | McKay Stewart als F-16 Pilot |
 | Terry Walters als Woman in Prius |
 | Katija Pevec als Teenage Page |
| Chase Penny als Capitol Policeman #1 |
 | Madison Mason als President |
 | Kevin Quinn als Pentagon Aide |
 | Sebastian Tillinger als Pentagon Agent |
 | Enver Gjokaj als Remote Pilot |
 | Michael Potter als Doorkeeper |
 | Webster Williams als Committee Head |
 | Peggy Roeder als Forensics Agents |
 | Gary Houston als Forensics Agents |
 | Jonathan Chase als Suited Agent |
 | Dean Cudworth als Capitol Policeman #2 |
| Lindsay Corinn Luecht als Girl on Train |
 | Nicol Paone als Rachel's Friend |
 | Brittany Ishibashi als Rachel's Friend |
 | Stacey Scowley als Waitress |
 | Stephen Simon als Secret Service Agent #2 |
| David Arakelyan als Ballochi Kid |
| Salah Salea als Funeral Chanter |
| Susan Armon als Woman in Ballochi Village |
 | Fahim Fazli als Al Kohei |
 | Elijah Moreland als Guard at Library of Congress |
| David Rowden als Sectran Truck Driver |
| Brenda Goodbeard als Speaker of the House |
| Caroline A. Jenks als Page |
| Roger Groh als Executive Aide to Callister |
| Leslie Stahl als Newscaster |
| Leyna Nguyen als Newscaster |
 | Ralph Garman als Newscaster |
 | Rick Chambers als Newscaster |
 | Sharon Tay als Newscaster |
| Kent Schocknek als Newscaster |
| Brandon Caruso als Boy on Train |
 | Julianne Moore als ARIIA (voice) (uncredited) |
 | Jerry Ferrara als Jerry's Friend #1 (uncredited) |
 | G. Larry Butler als Pentagon General Council (uncredited) |
 | Ali Olomi als Al Kohei - Afghan Soldier (uncredited) |
 | Nick Searcy als David Johnson (uncredited) |
 | Eric Bays als Man at ATM (uncredited) |
| Eddie Kunz als Catholic School Boy (uncredited) |
| Sean Kinney als JTAC Team Leader |
 | Angelina Lyubomirova als ATM Client (uncredited) |
| D. J. Caruso | Director |
| Patrick Crowley | Producer |
| Roberto Orci | Producer |
| Tricia Wood | Casting |
| Marie-Sylvie Deveau | Costume Design |
| Alex Kurtzman | Producer |
| Jennifer L. Smith | Casting |
| Steven Spielberg | Executive Producer |
| Sean Haworth | Art Direction |
| Naaman Marshall | Art Direction |
| Russell O'Connor | Construction Coordinator |
| John J. Slove Jr. | Construction Coordinator |
| Bob Peitzman | CG Supervisor |
| Marc Fisichella | Art Direction |
| Janice Kinigopoulos | Hairstylist |
| Jenne Lee | Art Department Coordinator |
| Peter Chesney | Special Effects Coordinator |
| Kristina Vogel | Makeup Department Head |
| Masako Masuda | Set Designer |
| Jim Berney | Visual Effects Supervisor |
| Martin Schaer | Camera Operator |
| David B. Nowell | Helicopter Camera |
| Nick Monton | Digital Intermediate |
| Thomas E. Sanders | Production Design |
| Nick Stanton | Leadman |
| Christopher Assells | Sound Effects Editor |
| Bob Beemer | Sound Re-Recording Mixer |
| Robert Q. Mathews | Costume Supervisor |
| Missy Papageorge | Digital Intermediate |
| Dan Hegeman | Sound Effects Editor |
| Cory Mandel | Sound Re-Recording Mixer |
| David C. Bryant | CGI Supervisor |
| Eugene F. Crededio | Rigging Gaffer |
| Stefan Sonnenfeld | Digital Intermediate |
| Linda Rizzuto | Hairstylist |
| Keith Sayer | Makeup Department Head |
| Quentin Matthys | Leadman |
| Domenic Silvestri | Set Designer |
| Amy L. Disarro | Makeup Artist |
| Shane Reed | Leadman |
| Unjoo Lee Byars | Visual Effects Producer |
| Crystal Dowd | Visual Effects Producer |
| David Sosalla | Visual Effects Supervisor |
| Karen Baker Landers | Supervising Sound Editor |
| Jim Page | Editor |
| Tom Cummins | Set Costumer |
| Debi Young | Makeup Artist |
| Joe Ondrejko | Construction Coordinator |
| Bruce Tanis | Sound Effects Editor |
| Don Parsons | Special Effects Coordinator |
| Jody Williams | Camera Operator |
| Kerry Hayes | Still Photographer |
| Tom Rebber | Picture Car Coordinator |
| Cheryl Eckert | Hairstylist |
| Michael Minkler | Sound Effects Editor |
| Steve Rhee | Visual Effects Editor |
| Patrick B. O'Brien | Additional Camera |
| Jordan Corngold | Music Editor |
| Cindy Carr | Set Decoration |
| Katherine Rees | Hairstylist |
| Per Hallberg | Supervising Sound Editor |
| Ralph Nelson Jr. | Still Photographer |
| Joani Yarbrough | Hairstylist |
| Lynne K. Eagan | Makeup Artist |
| Lindsay Good | Art Department Coordinator |
| Dewaldt Hicks | Sculptor |
| Amy Heinz-Barnett | Set Designer |
| Peter Staubli | Sound Effects Editor |
| Kim Lee | Visual Effects Producer |
| Don Lee | Visual Effects Supervisor |
| Roger Meilink | Rigging Gaffer |
| Karen Golden | Script Supervisor |
| Ed W. Marsh | Visual Effects Editor |
| Steve Duncan | Transportation Coordinator |
| Marina Marit | Set Costumer |
| Deborah Wuliger | Unit Publicist |
| Maurice K. McGuire | Camera Operator |
| Jim Rygiel | Visual Effects Supervisor |
| Gregg Smrz | Stunt Coordinator |
| Jay Kemp | Gaffer |
| Charlotte Parker | Hairstylist |
| Martha Johnston | Assistant Art Director |
| Scott Troha | Leadman |
| Dan O'Connell | Foley |
| Dino DiMuro | Sound Effects Editor |
| Albert Gasser | Sound Effects Editor |
| Crys Forsyth-Smith | Visual Effects Producer |
| Cari Thomas | Visual Effects Producer |
| Jacques Jouffret | Steadicam Operator |
| Jennifer Jobst | Costume Supervisor |
| Kevin Kavanaugh | Supervising Art Director |
| Dariusz Wolski | Director of Photography |
| Brian Tyler | Original Music Composer |
| Tim Rigby | Stunts |
| Hillary Seitz | Screenplay |
| Kimaree Long | Dialogue Editor |
| Chris Jargo | ADR Supervisor |
| John Glenn | Screenplay |
| Chris Hogan | Dialogue Editor |
| Kirk Francis | Sound Mixer |
| Frederick H. Stahly | Dialogue Editor |
| Dan McDermott | Screenplay |
| Joseph Timothy Conway | Property Master |
| Michelle Pazer | ADR Editor |
| Travis Wright | Screenplay |
| Dan McDermott | Story |
| Michael D. Gianneschi | Property Master |
| Larry Blanford | Second Unit Director of Photography |
| Colin Follenweider | Stunts |
| Donna Evans | Stunts |
| Alex Madison | Stunts |
| Horace Knight Jr. | Stunts |
| Rick LeFevour | Stunts |
| Brett A. Jones | Stunts |
| Dean Bailey | Stunts |
| Jake Brake | Stunts |
| Gilbert B. Combs | Stunts |
| Tobiasz Daszkiewicz | Stunts |
| Corey Michael Eubanks | Stunts |
| Keii Johnston | Stunts |
| Paul M. Lane | Stunts |
| Johnny Martin | Stunts |
| Carl Paoli | Stunts |
| Kevin Scott | Stunts |
| Kevin Swigert | Stunts |
| Merritt Yohnka | Stunts |
| Allen Kupetsky | Second Assistant Director |
| Shauna Duggins | Stunts |
| Henry Kingi | Stunts |
| Eliza Coleman | Stunts |
| Linda Perlin | Stunts |
| Jimmy N. Roberts | Stunts |
| Brian Smrz | Second Unit Director |
| Natalie M. Meyer | Stunts |
| Dane Farwell | Stunts |
| Danny Wynands | Stunts |
| Al Goto | Stunts |
| Casey O'Neill | Stunt Double |
| Mickey Giacomazzi | Stunt Double |
