 | Nia Vardalos als Toula Portokalos-Miller |
 | John Corbett als Ian Miller |
 | Elena Kampouris als Paris Miller |
 | Michael Constantine als Kostas "Gus" Portokalos |
 | Lainie Kazan als Maria Portokalos |
 | Andrea Martin als Aunt Voula |
 | Gia Carides als Nikki Portokalos |
 | Joey Fatone als Angelo |
 | Louis Mandylor als Nick Portokalos |
 | Alex Wolff als Bennett |
 | Bess Meisler als Mana-YiaYia |
 | Bruce Gray als Rodney Miller |
 | Fiona Reid als Harriet Miller |
 | Ian Gomez als Mike |
 | Jayne Eastwood als Mrs. White |
 | Rob Riggle als Northwestern Rep |
 | Mark Margolis als Panos |
 | Rita Wilson als Anna |
 | John Stamos als George |
 | Jeanie Calleja als Ilaria |
| Michael Sofos als Costa |
 | Stavroula Logothettis als Athena |
 | Leonidas Castrounis als Aristotle |
| Peter Tharos als Yianni |
 | Harper Gunn als Paris at 4 |
 | Hershel Blatt als Tommy |
 | Tannis Burnett als Edie |
 | Kathryn Greenwood als Marge |
 | Teresa Pavlinek als Dominique |
 | Aniela Kurylo als Physical Therapist |
 | Sam Moses als Kaveh |
| Roger Wong als Pim |
| Alec Stockwell als Baird |
 | Gerry Mendicino als Uncle Taki |
 | Kathryn Haggis als Marianthi |
 | Kolton Stewart als Clifford |
| Theodore Paraskevopoulos als Priest |
 | Ethan Pugiotto als Theadore |
| Ashleigh Rains als Wedding Planner |
| Chrissy Paraskevopoulos als Jennie |
 | Maria Vacratsis als Aunt Freida |
| Julia Gartha als Tiahn |
 | Jeff White als Patrick |
| Constantine Vardalos als Chanter |
| Lauren Saarimaki als Elizabeth |
| Robert Bellissimo als Toula's Nephew (uncredited) |
| Dave Reachill als Teacher (uncredited) |
| Maxillian Grimm als Chef (uncredited) |
| Christopher D. Lindsay als Student (uncredited) |
| Kirk Jones | Director |
| Nia Vardalos | Writer |
| Nori Chia | Associate Producer |
| Paul Brooks | Executive Producer |
| David Coatsworth | Co-Producer |
| Markus Czyzewski | Editor |
| Siân McArthur | Associate Producer |
| Nia Vardalos | Executive Producer |
| Tom Hanks | Producer |
| Steven Shareshian | Executive Producer |
| Jonathan Shore | Associate Producer |
| Christopher Lennertz | Music Editor |
| Scott Niemeyer | Executive Producer |
| Gregory P. Keen | Production Design |
| Rita Wilson | Producer |
| Gersha Phillips | Costume Design |
| Jim Denault | Cinematography |
| James Banos | Set Decoration |
| Christopher Lennertz | Music |
| D.J. Carson | Unit Production Manager |
| David Coatsworth | Unit Production Manager |
| Bryan C. Knight | First Assistant Director |
| Patrick Murphy | Second Assistant Director |
| Branko Racki | Stunt Coordinator |
| Marco Bianco | Stunts |
| Gannon Racki | Stunts |
| Joseph Racki | Stunts |
| Robert Racki | Stunts |
| Ashley Dawn Szabadi | Stunts |
| Keith Murphy | Steadicam Operator |
| Tom Starnes | Gaffer |
| Robert Johnson | Key Grip |
| Glen Gauthier | Production Sound Mixer |
| Brad Besser | First Assistant Editor |
| John Ross | Sound Re-Recording Mixer |
| Christian P. Minkler | Sound Re-Recording Mixer |
| Martyn Zub | Supervising Sound Editor |
| Michele Perrone | Supervising ADR Editor |
| Michele Perrone | Supervising Dialogue Editor |
| Nigel Churcher | Art Direction |
| Patricia Cuccia | Set Decoration |
| Tory Bellingham | Property Master |
| Marie Nardella | Makeup Department Head |
| Paul R.J. Elliot | Hair Department Head |
| Robin D. Cook | Local Casting |
| Debbie Van Dusen | Production Accountant |
| Susan Marucci | Script Supervisor |
| Megan Oppenheimer | Assistant Costume Designer |
| Vladislav Fedorov | First Assistant Art Direction |
| Jonathan Gotfryd | Second Assistant Art Director |
| Sean Scoffield | Graphic Designer |
| Jamie Frith | Art Department Coordinator |
| Greg Langham | Leadman |
| Vincent Harper | Leadman |
| Jamie Lynn Vaughan | On Set Dresser |
| James Banos | Set Dressing Buyer |
| Andrea Tóth | Set Dressing Buyer |
| George Stouros | Set Dresser |
| Brandon Calvert | Set Dresser |
| Jane Janigan | Set Dresser |
| Darren Kelly | Set Dresser |
| Peeter Tammemagi | Property Buyer |
| Cylvan Desrouleaux | First Assistant Camera |
| Jay Jay Callan | Second Assistant Camera |
| JP Locherer | "B" Camera Operator |
| Mark Giles | First Assistant "B" Camera |
| Rudolf Mammitzsch | Second Assistant "B" Camera |
| George Kraychyk | Still Photographer |
| Steve Switzer | Boom Operator |
| Vivian Orgill | Key Makeup Artist |
| Rose-Mary Holosko | Assistant Makeup Artist |
| Sondra Treilhard | Key Hair Stylist |
| Albena Zlatanov | Assistant Hairstylist |
| Patricia Boulden | Costume Supervisor |
| Jenn Burton | Truck Supervisor |
| Blake Connell | Best Boy Electric |
| Sean Osadzuk | Electrician |
| Vincent Borg | Electrician |
| Andrew Meredith | Electrician |
| Ko Maddock | Electrician |
| John Piva | Generator Operator |
| Jason Dodds | Rigging Gaffer |
| James Holmes | Best Boy Grip |
| Ron Renzetti | Dolly Grip |
| Mike Yabuta | Dolly Grip |
| Andrew Caney | Grip |
| Robert Rice | Grip |
| Wilton Higgins | Grip |
| Shawn McCarthy | Grip |
| Jonathan Billings | Key Rigging Grip |
| Fabian MacDonald | Rigging Grip |
| Paul Sweeney | Rigging Grip |
| Keith Large | Location Manager |
| Alexander McNaughton | Assistant Location Manager |
| Mark Moore | Assistant Location Manager |
| Alberto Patella | Assistant Location Manager |
| John Rakich | Location Scout |
| Chris Vargas | Location Production Assistant |
| Brandon Scherenzel | Location Production Assistant |
| Kimberley Bradley | Production Coordinator |
| Norm Waitt | Thanks |
