 | Owen Wilson als Carl Nargle |
 | Michaela Watkins als Katherine |
 | Wendi McLendon-Covey als Wendy |
 | Ciara Renée als Ambrosia |
 | Lusia Strus als Beverly |
 | Stephen Root als Tony |
 | Lucy Freyer als Jenna |
 | Denny Dillon als PBS Host |
 | Evander Duck Jr. als Reuben |
 | Elisabeth Henry-Macari als Bridget |
 | Michael Pemberton als Dr. Bradford Lenihan |
 | Rob Figueroa als Donald Moore |
 | Elizabeth Loyacano als Alexandra Moore |
| Sonia Darmei Lopes als Mary |
 | Joel Leffert als Sydney |
 | Noa Graham als Dean Gregory |
| Paul Kosopod als Bridget's Best Friend |
 | Ryan Czerwonko als Young Bar Regular |
| Aidan T.K. Baker als Strong Bar Regular |
 | Vin Craig als SuperFan |
 | Chris Gaunt als Waiter |
 | Lynda Suarez als Ambrosia's Mom |
 | Sarah Baker als Lady in the Window |
 | Brit McAdams als The Whittler |
| Sylvia Fletcher als Ventriloquist |
 | Ryan Gaul als Vermont Mountain Express |
| Phoenix Na als Female Student |
 | Crystal Tweed als PBS President Vermont |
| Dina Washington als Ambrosia's Grandma |
 | Colin J. Sweeney als Milk and Cheese Man |
 | Kristin Hensley als Milk and Cheese Woman |
 | Scott Beehner als Newscaster 1 |
 | Jen Smedley als Newscaster 2 |
| Brit McAdams | Director |
| Brit McAdams | Writer |
| Sam Maydew | Producer |
| Peter Brant | Producer |
| Owen Wilson | Executive Producer |
| Richard J. Bosner | Executive Producer |
| Joel David Moore | Executive Producer |
| Sofi Marshall | Editor |
| Patrick Cady | Director of Photography |
| Todd Jeffery | Production Design |
| Cassandra Holden | Art Direction |
| Kierra Jordan | Set Decoration |
| Elizabeth Fox | Makeup Department Head |
| Josie Rodriguez | Makeup Department Head |
| Kristy Strate | Key Makeup Artist |
| Kekepania Vasquez-Tamali'i | Hair Designer |
| Erica Villanueva | Key Hair Stylist |
| Michael Odmark | Sound Effects Editor |
| Michael Odmark | Sound Mixer |
| Michael Kurihara | Sound Re-Recording Mixer |
| Mike Uguccioni | Visual Effects Supervisor |
| Jake Martin | First Assistant Director |
| Hannah Sheinkopf | Second Assistant Director |
| Alexis Vail | Second Second Assistant Director |
| Stratton Bailey | Key Grip |
| Jade Brennan | Assistant Camera |
| Josh Haslup | Dolly Grip |
| Chase Lowenstein | Second Assistant "A" Camera |
| Nick Negersmith | Grip |
| Mike Prisco | Gaffer |
| Imanuel Smith | Digital Imaging Technician |
| Jennie Shea | ADR Recordist |
| Lyle Workman | Original Music Composer |
| Aana Myers | Associate Producer |
| Chad Knorr | Stunt Coordinator |
| Mark Pettograsso | Stunt Driver |
| Jason A. Iannacone | Stunt Double |
| Thomas Place | Stunt Driver |
| Sonia Foltarz | Art Department Coordinator |
| Amy Jarvela | Executive Producer |
| Michael Turner | Music Supervisor |
| Allison Pearce | Costume Design |
| Rebecca Dealy | Casting |
| Amy Jarvela | Unit Production Manager |
| Ryan Bojanovic | Graphic Designer |
| Michael D'Alessio | On Set Dresser |
| Thomas Jedlicka | Set Dresser |
| Alexis Lasky | Set Dresser |
| Shane McDonaugh | Set Dresser |
| Thorstein Foss | Property Master |
| Noa Rachel Bricklin | Assistant Property Master |
| Jesse Coyote Sanchez-Strauss | "A" Camera Operator |
| Cameron S. Mitchell | "B" Camera Operator |
| Logan Gee | First Assistant "B" Camera |
| Richard Martin | First Assistant "A" Camera |
| Jade Brennan | Second Assistant "B" Camera |
| Matt Martin | Digital Imaging Technician |
| Dan Holodak | Camera Production Assistant |
| Willa Pisarski | Camera Production Assistant |
| Matthew Kane | Best Boy Electric |
| Sean Girton | Electrician |
| Jason Yip | Electrician |
| Stephen Long | Best Boy Grip |
| Paul Losada | Production Sound Mixer |
| Bret Scheinfeld | Boom Operator |
| Maren Reese | Wardrobe Supervisor |
| Ricardo Louison | Key Costumer |
| Kekepania Vasquez-Tamali'i | Wig Designer |
| Kekepania Vasquez-Tamali'i | Hair Department Head |
| Yulitzin Alvarez | Hairstylist |
| Brooke Lynski | Additional Hairstylist |
| Benjamin Gamer | Location Manager |
| Greg Ronayne | Assistant Location Manager |
| Kaitlin Nash | Location Assistant |
| David Snyder | Location Assistant |
| Wesley Swanson III | Script Supervisor |
| Anthony Argento | Production Supervisor |
| Betty Chin | Production Coordinator |
| Laura Archer | Assistant Production Coordinator |
| Wonnie Shen | Production Secretary |
| Ariel Loewenthal | Key Production Assistant |
| David Snook | Production Accountant |
| Rebecca Birstock | Casting Associate |
| Heidi K. Eklund | Local Casting |
| Warren Ciootte | Key Construction Grip |
| Taylor Barry | Scenic Artist |
| Robert Joseph Taylor IV | Scenic Artist |
| Richard Christie Jr. | Transportation Captain |
| Brian Spitzfaden | Transportation Co-Captain |
| Angel Pina | Chef |
| John Salinas | Assistant Chef |
| Janna Emig | Additional Editor |
| Isabel Henderson | Post Production Supervisor |
| Christi Kurihara | Post Production Coordinator |
| Griffin Bruce | Post Production Assistant |
| Gyooheon Lee | Post Production Assistant |
| Michael Kurihara | Supervising Sound Editor |
| Rachel Wardell | Dialogue Editor |
| Mark DeSimone | ADR Mixer |
| Chris White | ADR Mixer |
| Kristin Catuogno | ADR Recordist |
| Jevon Johnson | Sound Re-Recording Assistant |
| Leslie Bloome | Foley Artist |
| Ryan Collison | Foley Mixer |
| Connor Nagy | Foley Mixer |
| Nick Seaman | Foley Editor |
| Annie Taylor | Foley Supervisor |
| Wade Ivy | VFX Supervisor |
| Frank Fieser | VFX Supervisor |
