 | Andy Samberg als Nyles |
 | Cristin Milioti als Sarah |
 | J.K. Simmons als Roy |
 | Peter Gallagher als Howard |
 | Meredith Hagner als Misty |
 | Camila Mendes als Tala |
 | Tyler Hoechlin als Abe |
 | Chris Pang als Trevor |
 | Jacqueline Obradors als Pia |
 | June Squibb als Nana Schlieffen |
 | Tongayi Chirisa als Jerry |
 | Dale Dickey als Darla |
 | Conner O'Malley als Randy |
 | Jena Friedman als Daisy the Bartender |
 | Brian Duffy als Spuds |
 | Martin Kildare als Ted the Bartender |
 | Lilli Birdsell als Jamie |
 | Ryan Sturtz als Cop |
| Clifford V. Johnson als Professor |
| Calki Garcia als DJ Nice Height |
 | Michelle Johnston als Nosy Neighbor |
| Isla Sellers als Roy's Daughter |
| Matt Smith als Out of Town Dad |
| Rebecca Smith als Out of Town Mom |
| Jake Smith als Out of Town Older Son |
| Noah Smith als Out of Town Younger Son |
| Rocky Bonifield als Wedding Guest (uncredited) |
 | Erin Flannery als Wedding Guest (uncredited) |
 | David Hutchison als Biker (uncredited) |
 | Mark Kubr als Biker (uncredited) |
| David Philip Reed als Truck Driver (uncredited) |
| Jorma Taccone | Producer |
| Becky Sloviter | Producer |
| Akiva Schaffer | Producer |
| Dylan Sellers | Producer |
| Max Barbakow | Director |
| Andy Samberg | Producer |
| Gabriela Revilla Lugo | Executive Producer |
| Quyen Tran | Director of Photography |
| Matthew Friedman | Editor |
| Matthew Compton | Original Music Composer |
| Jason Kisvarday | Production Design |
| Andrew Dickler | Editor |
| Alex Dong | Executive Producer |
| Kelsi Ephraim | Set Decoration |
| Colin Wilkes | Costume Design |
| Allison Jones | Casting |
| Jon Wakeham | Supervising Sound Editor |
| Dylan Acio | Boom Operator |
| Robert Chen | Sound Re-Recording Mixer |
| Tim Ford | Art Direction |
| Chris Parker | Producer |
| Andy Siara | Screenplay |
| Robin Urdang | Music Supervisor |
| Ken Fournier | Stunts |
| Marcy Silver | Property Master |
| Ilyana Eberhardt | Stunts |
| Chad Bennett | Stunts |
| Miluette Nalin | Stunts |
| C.J. Barbato | Associate Producer |
| Erin Thiele | Set Decoration Buyer |
| Katie Mamie | Set Decoration Buyer |
| Carlos Lugo | Unit Production Manager |
| Kristin Elshout | Set Decoration Buyer |
| Chris Carnel | Stunts |
| Ray Siegle | Stunts |
| Kim Barnard | Second Assistant Director |
| James Zahnd | Stunts |
| Kevin Beebe | Assistant Property Master |
| Brandi Benkert | Set Designer |
| Jay Schwartz | First Assistant Director |
| David Hutchison | Stunts |
| Jonas Madden-Connor | Graphic Designer |
| Rene Mousseux | Stunts |
| Susan Purkhiser | Stunts |
| Jessica Olthof | Production Coordinator |
| Terry James | Stunts |
| Alex Nawrocki | Leadman |
| Henry Kingi Jr. | Stunts |
| Tim James | Stunts |
| Mike Fisher | Graphic Designer |
| Seth Duhame | Stunts |
| Joseph Suarez | Consulting Producer |
| T.J. White | Stunt Coordinator |
| Mark Kubr | Stunts |
| Jason Tubbs | Stunts |
| Chad Persons | "B" Camera Operator |
| Pete Escobar | Best Boy Grip |
| Robyn Simms | Tailor |
| Tim Tuchrello | First Assistant Sound Editor |
| Ellen Nielsen | Set Dresser |
| Renni Pollock | Second Assistant "A" Camera |
| Jay Golden | Boom Operator |
| Tom Ceglia | Special Effects Supervisor |
| Anne Kemmeter | Set Costumer |
| Laura Jean Bransky | Script Supervisor |
| Armando Macias | Production Sound Mixer |
| Rachael Hranka | Costumer |
| Peter Kukla | Hairstylist |
| Lisa Wax | Assistant Location Manager |
| Justin Olthof | Production Secretary |
| Paul Pirola | Sound Designer |
| Cory Milano | Music Editor |
| Fernando Acosta | Set Dresser |
| Ellie O'Neill | Set Dresser |
| Kirsti Schroder | Costumer |
| Tesa Diaz | Tailor |
| Chelsea Orduno | Makeup Artist |
| Patrick Cyccone Jr. | Sound Re-Recording Mixer |
| Stephan Dalyai | Chief Lighting Technician |
| Rene Diamante | Special Effects Technician |
| Chris Wienckowski | Transportation Captain |
| Mario Gonzalez | Set Dresser |
| Dana Carr | Costumer |
| Emily Buntyn | Casting Assistant |
| Shane Carlson | First Assistant "B" Camera |
| Matthew Berner | First Assistant "B" Camera |
| Chris Willard | Still Photographer |
| Sandra Waesche | Costumer |
| Patricia Vecchio | Hairstylist |
| Catherine Charpentier | Costumer |
| Margo Rombough | Costumer |
| Galaxy San Juan | Makeup Department Head |
| Cory Hart | Aerial Director of Photography |
| S. Dylan Kirkland | Location Manager |
| Grant Cdebaca | Set Dresser |
| Kieran Roberts | Set Dresser |
| Chris De La Riva | Second Assistant "B" Camera |
| Brian Wells | First Assistant "A" Camera |
| Michael Romano | Digital Imaging Technician |
| Max Duck | Set Dresser |
| Gabriel DeMonte-Finn | Set Dresser |
| Patrick H. McGinness | Key Grip |
| Tom Scott-Toft | Sound Effects Editor |
| Alicia Pharris | Second Assistant "B" Camera |
| Kevan Tucker | Assistant Location Manager |
| Mark Webb | Transportation Coordinator |
| Bill Lynch | Assistant Editor |
| Megan Drayton | Second Assistant "A" Camera |
| Anthony Ceglia | Special Effects Technician |
| Karrel Graves | Special Effects Technician |
| Bridget Chapman | Set Costumer |
| Teresa Aguilera | Makeup Artist |
| Ben Harris | Casting Associate |
| Corey Askins | Transportation Captain |
| Sarah Schueler | Picture Car Coordinator |
| Robert Settlemire | Underwater Director of Photography |
| Willie Berumen | Transportation Captain |
| Brendan Hill | Sound Effects Editor |
| Brad McLaughlin | Associate Editor |
| Robert Chen | Supervising ADR Editor |
| Scenery Samundra | Music Coordinator |
| Taylor Bentley | Set Dresser |
| Ryan Salisbury | Set Dresser |
| Alexandra Cason | First Assistant "A" Camera |
| Edward C. Peters | Dolly Grip |
| Safowa Bright-Asare | Costume Supervisor |
| Kimberley Spiteri | Hair Department Head |
| Julia Tasker | Script Supervisor |
| Peggy Yen | Production Accountant |
| Craig Fikse | "B" Camera Operator |
| Vanessa Portillo | Extras Casting |
| Louie Schultz | Music Editor |
| Jack Van Nuis | Digital Compositor |
| Ndosi Anyabwile | Digital Compositor |
| Joshua Bailor | Digital Compositor |
| Adam Pere | Visual Effects Producer |
| Tim LeDoux | Visual Effects Supervisor |
| Brian Fortune | Digital Compositor |
| John Brubaker | Compositing Supervisor |
| Jasper M. Baltzersen | Digital Compositor |
| Nicholas Daniels | Digital Compositor |
| Daniel Dupre | Matte Painter |
| Joshua Little | CG Artist |
| Andrew Kalicki | Visual Effects Coordinator |
| Tomohiko Fukuda | Digital Compositor |
| Sam Winkler | Visual Effects Supervisor |
| Max Barbakow | Story |
| Andy Siara | Story |
