 | Charles Fleischer als Roger Rabbit (voice) |
 | Kathleen Turner als Jessica Rabbit (voice) |
 | April Winchell als Young Baby Herman / Mrs. Herman (voice) |
 | Lou Hirsch als Adult Baby Herman (voice) |
 | Corey Burton als Droopy Dog (voice) |
 | Frank Welker als Bull (voice) |
 | Damian London als Fritz |
 | Joni Barnes als Secretary |
| Jimmy Bracken als Cameraman |
| Angel Cook als Fireman |
| Steven Spielberg | Executive Producer |
| Kevin Harkey | Story |
| Frank Marshall | Director |
| Thom Enriquez | Producer |
| Rob Minkoff | Director |
| Patrick A. Ventura | Story |
| Gary K. Wolf | Characters |
| Chuck Williams | Editor |
| Bill Kopp | Story |
| Donald W. Ernst | Producer |
| Frank Marshall | Executive Producer |
| Kathleen Kennedy | Executive Producer |
| Bruce Broughton | Original Music Composer |
| Lynne Naylor | Story |
| Hiro Narita | Director of Photography |
| Aaron Blaise | Animation |
