 | Jeff Goldblum als Seth Brundle |
 | Geena Davis als Veronica Quaife |
 | John Getz als Stathis Borans |
 | Joy Boushel als Tawny |
 | Leslie Carlson als Dr. Brent Cheevers |
 | George Chuvalo als Marky |
 | Michael Copeman als 2nd Man in Bar |
 | David Cronenberg als Gynecologist |
 | Carol Lazare als Nurse |
| Shawn Hewitt als Clerk |
 | Typhoon als Baboon (uncredited) |
| Ann Green als Restaurant Patron (uncredited) |
| David Cronenberg | Director |
| Charles Edward Pogue | Screenplay |
| David Cronenberg | Screenplay |
| Stuart Cornfeld | Producer |
| Howard Shore | Original Music Composer |
| Mark Irwin | Director of Photography |
| Ronald Sanders | Editor |
| Denise Cronenberg | Costume Design |
| Rolf Harvey | Art Direction |
| Ivan Lynch | Hairstylist |
| Marc Boyman | Co-Producer |
| Kip Ohman | Co-Producer |
| Carol Spier | Production Design |
| Deirdre Bowen | Casting |
| Chris Walas | Creature Design |
| Elinor Rose Galbraith | Set Decoration |
| Shonagh Jabour | Makeup Artist |
| Nick Kosonic | Scenic Artist |
| James McAteer | Set Designer |
| Jane Tattersall | Sound Effects Editor |
| Gerry Humphreys | Sound Re-Recording Mixer |
| Robin O'Donoghue | Sound Re-Recording Mixer |
| David Evans | Supervising Sound Editor |
| Wayne Griffin | Supervising Sound Editor |
| Katherine Kean | Animation |
| Mitchell Rothzeid | Animation |
| Lee Wilson | Visual Effects Supervisor |
| Hoyt Yeatman | Visual Effects Supervisor |
| Dwayne McLean | Stunt Coordinator |
| Scotty Allan | Gaffer |
| Robin Miller | Additional Photography |
| Kenneth Post | Additional Photography |
| Attila Dory | Still Photographer |
| Michael Rea | First Assistant Editor |
| Jim Weidman | Music Editor |
| Matthew Wolchock | Transportation Coordinator |
| Gillian Richardson | Script Supervisor |
| Howard Rothschild | Location Manager |
| Prudence Emery | Unit Publicist |
| David Coatsworth | Unit Production Manager |
| Debbie Cooke | Production Coordinator |
| Jack Hooper | Negative Cutter |
| Homer Denison | Orchestrator |
| John Board | First Assistant Director |
| Kim H. Winther | Second Assistant Director |
| Marc Corriveau | Property Master |
| Richard Cadger | Dialogue Editor |
| George Langelaan | Short Story |
| Patricia Rozema | Third Assistant Director |
| Marvin Midwicki | First Assistant Camera |
| Donna Mobbs | Second Assistant Camera |
| Joe Curtin | Construction Manager |
| Danielle Fleury | Set Dresser |
| Ian Fraser | Head Carpenter |
| Gary Jack | Set Dresser |
| Nancey Pankiw | First Assistant Art Direction |
| Terry Burke | Foley Artist |
| Bryan Day | Production Sound Mixer |
| Michael LaCroix | Production Sound Mixer |
| Robin Leigh | ADR Editor |
| Louis Craig | Special Effects |
| Ted Ross | Special Effects |
| Mark Manchester | Key Grip |
| Tom Quinn | Third Assistant Director |
| Paul Hotte | Assistant Property Master |
| Ian Wheatley | Assistant Set Dresser |
| Donald Engel | Carpenter |
| Pat Calvert | Assistant Sound Editor |
| Michael Followes | Assistant Sound Editor |
| David Giammarco | Assistant Sound Editor |
| Susan Maggi | Assistant Sound Editor |
| Sandra Moffat | Assistant Sound Editor |
| Steve Munro | Assistant Sound Editor |
| Don White | ADR Recordist |
| Don White | Foley Mixer |
| Clark Johnson | Special Effects |
| Lesley Mallgrave | Visual Effects Supervisor |
| Tom Bisogno | CG Animator |
| Paul Griffin | Senior Animator |
| Brent Meyer | Stunt Double |
| Sam Bojin | Electrician |
| Charlotte Disher | Camera Trainee |
| David Hynes | Dolly Grip |
| Don Payne | Grip |
| Ian D. Scott | Electrician |
| David Willetts | Best Boy Electric |
| Trysha Bakker | Wardrobe Master |
| Cherie MacNeill | Assistant Editor |
| Carol McBride | Post Production Coordinator |
| Kant Pan | Assistant Editor |
| Susan Shipton | Assistant Editor |
| Richard Bissill | Musician |
| Michael Boddicker | Musician |
| Skaila Kanga | Musician |
| Howard Shore | Conductor |
| Jonathan Snowden | Musician |
| Doreen Davis | Production Accountant |
| Wayne Fitzgerald | Title Designer |
| Gary Kanew | Title Designer |
| Doron Kernerman | Stunt Double |
| Susan Kinnevy | Producer's Assistant |
| Susan C. MacQuarrie | Craft Service |
| Barbara Mainguy | Producer's Assistant |
| Rick Schmidlin | Producer's Assistant |
| Romuald Sunny | Stunt Double |
| Randy Auerbach | Producer's Assistant |
| Michael Lennick | Technical Advisor |
| Tony Laudati | Creature Effects Technical Director |
