 | David Duchovny als Tom |
 | Julianne Moore als Rebecca |
 | Billy Crudup als Tobey |
 | Maggie Gyllenhaal als Elaine |
 | Justin Bartha als Jasper Bernard |
 | Eva Mendes als Faith Faison |
 | Ellen Barkin als Norah |
 | Garry Shandling als Dr. Beekman |
 | Sterling K. Brown als Rand |
 | Liam Broggy als David |
 | Dagmara Domińczyk als Pamela |
 | Jim Gaffigan als Gordon |
 | James Le Gros als Dante |
 | Gretchen Cleevely als Assistant Stage Manager |
 | David Greenspan als Francis, the Director |
 | Bob Balaban als Tobey's Therapist |
| Bart Freundlich | Writer |
| Bart Freundlich | Director |
| Paul Bernard | Associate Producer |
| Bart Freundlich | Producer |
| Marina Grasic | Executive Producer |
| Pamela Hirsch | Line Producer |
| Todd M. Hofacker | Producer |
| Sidney Kimmel | Producer |
| Evelyn O'Neill | Executive Producer |
| Tim Perell | Producer |
| Bruce Toll | Executive Producer |
| Meredith Zamsky | Associate Producer |
| Clint Mansell | Original Music Composer |
| Tim Orr | Director of Photography |
| John Gilroy | Editor |
| Douglas Aibel | Casting |
| Kevin Thompson | Production Design |
| John Nyomarkay | Art Direction |
| Mila Khalevich | Set Decoration |
| Michael Clancy | Costume Design |
| Annemarie Bradley | Hairstylist |
| Maya Hardinge | Makeup Artist |
| Sherry Heart | Makeup Department Head |
| Amanda Ross | Makeup Artist |
| Rachel Chancey | Foley Editor |
| Andy Kris | Sound Re-Recording Mixer |
