 | Glenn Close als Cruella de Vil |
 | Jeff Daniels als Roger |
 | Joely Richardson als Anita |
 | Joan Plowright als Nanny |
 | Hugh Laurie als Jasper |
 | Mark Williams als Horace |
 | John Shrapnel als Skinner |
 | Tim McInnerny als Alonzo |
 | Hugh Fraser als Frederick |
 | Zohren Weiss als Herbert |
 | Mark Haddigan als Alan |
 | Michael Percival als Police Inspector |
 | Neville Phillips als Minister |
| John Evans als Pensioner with Bulldog |
| Hilda Braid als Woman On Park Bench |
 | Margery Mason als Woman On Park Bench |
 | John Benfield als Doorman |
 | Andrew Readman als Police Officer #1 |
 | John Peters als Police Officer #2 |
 | Bill Stewart als Arresting Officer |
 | Gerald Paris als Doctor |
| Joe Lacey als Veterinarian |
 | Brian Capron als Television News Reporter |
| John Hughes | Screenplay |
| Edward S. Feldman | Executive Producer |
| Michael Kamen | Music |
| John Hughes | Producer |
| Stephen Herek | Director |
| Ricardo Mestres | Producer |
| Trudy Ship | Editor |
| Adrian Biddle | Director of Photography |
| Rich Draper | Animation |
| John Dillon | Animation |
| Peter N. Brown | Carpenter |
| David Molina | Creative Producer |
| Larry Bock | Additional Editor |
| Anthony Powell | Costume Design |
| Rosemary Burrows | Costume Design |
| Assheton Gorton | Production Design |
| Fraser Taggart | Focus Puller |
| Michael D. Moore | Second Unit Director |
| Dodie Smith | Novel |
| Rebekah Rudd | Associate Producer |
| John Ralph | Art Direction |
| Alan Tomkins | Supervising Art Director |
| Joanne Woollard | Set Decoration |
| Lynda Armstrong | Makeup Artist |
| Martial Corneville | Hairdresser |
| Belinda Hodgson | Makeup Artist |
| Jean-Luc Russier | Makeup Artist |
| Robert Grayson | Third Assistant Director |
| Toby Hosking | Assistant Director |
| Adam Somner | Second Assistant Director |
| David Tringham | First Assistant Director |
| Carmen Baker | First Assistant Sound Editor |
| Jim Brookshire | Sound Effects Editor |
| Ed Callahan | Sound Effects Editor |
| Tim Chau | Supervising Sound Editor |
| Tim Chau | Sound Designer |
| Albert Gasser | Sound Effects Editor |
| Nils C. Jensen | Sound Effects Editor |
| David Kern | Sound Effects Editor |
| Donald J. Malouf | Sound Designer |
| Donald J. Malouf | Supervising Sound Editor |
| Piero Mura | Sound Effects Editor |
| Marion Appleton | Creature Design |
| Nigel Booth | Creature Design |
| Gary Cohen | Special Effects Technician |
| Carol De Jong | Creature Design |
| Paul Dimmer | Special Effects Technician |
| Robin Ellis | Animatronics Designer |
| Graham High | Creature Design |
| Mathew Horton | Special Effects Technician |
| Chris 'Flimsy' Howes | Animatronics Designer |
