 | Ron Perlman als Hellboy (voice) |
 | Selma Blair als Liz Sherman (voice) |
 | Doug Jones als Abe Sapien (voice) |
 | Peri Gilpin als Professor Kate Corrigan (voice) |
 | Gwendoline Yeo als Kitsune (voice) |
 | Dee Bradley Baker als Lightning / Kappa / Pilot (voice) |
 | Phil LaMarr als Bureau Member / Pilot / Additional Voices (voice) |
 | Mitchell Whitfield als Russell Thorne (voice) |
 | Kim Mai Guest als Additional Voices (voice) |
 | Michael Hagiwara als Additional Voices (voice) |
 | Yuriana Kim als Additional Voices (voice) |
 | Clyde Kusatsu als Additional Voices (voice) |
 | Liza del Mundo als Additional Voices (voice) |
 | Paul Nakauchi als Additional Voices (voice) |
 | James Sie als Additional Voices (voice) |
| Phil Weinstein | Director |
| Tad Stones | Director |
| Mike Mignola | Characters |
| Karen Inwood Somers | Documentation & Support |
| Tad Stones | Screenplay |
| Matthew Waynee | Screenplay |
| Karen Inwood Somers | Screenplay |
| Art Vitello | Animation Director |
| Mike Mignola | Story |
| Tad Stones | Story |
| Sidney Clifton | Producer |
| Scott Greenberg | Producer |
| Morris Berger | Executive Producer |
| Stephen R. Brown | Executive Producer |
| Guillermo del Toro | Creative Producer |
| Lawrence Gordon | Executive Producer |
| Scott Hemming | Executive Producer |
| John W. Hyde | Executive Producer |
| Lloyd Levin | Executive Producer |
| Mike Mignola | Consulting Producer |
| Mike Richardson | Executive Producer |
| Tad Stones | Supervising Producer |
| Michael Wolf | Executive Producer |
| Stephanie Elliott | Producer |
| Christopher Drake | Music |
| John Hoyos | Editor |
| Jeffrey Perlmutter | Editor |
| Bryndon Smith | Camera Operator |
