 | Christopher Plummer als Sherlock Holmes |
 | James Mason als Dr. John H. Watson |
 | David Hemmings als Inspector Foxborough |
 | Susan Clark als Mary Kelly |
 | Anthony Quayle als Sir Charles Warren |
 | John Gielgud als Prime Minister Lord Salisbury |
 | Frank Finlay als Inspector Lestrade |
 | Donald Sutherland als Robert Lees |
 | Geneviève Bujold als Annie Crook |
 | Chris Wiggins als Doctor Hardy |
 | Tedde Moore als Mrs. Lees |
 | Peter Jonfield als William Slade |
 | Roy Lansford als Sir Thomas Spivey |
 | Catherine Kessler als Carrie |
 | Ron Pember als Makins |
 | June Brown als Anne Chapman |
 | Ken Jones als Dock Guard |
| Terry Duggan als Danny |
| Hilary Sesta als Catherine Eddowes |
| Anthony May als Lanier |
| Betty Woolfe als Mrs. Dobson |
| Iris Fry als Elizabeth Stride |
| Geoffrey Russell als Home Secretary Henry Matthews |
| Peggy Ann Clifford als Lees' Housekeeper |
 | Ann Mitchell als Jane |
| Katherine Stark als Molly |
| Elaine Ives-Cameron als Ellen |
| Stella Courtney als Betty |
| Judy Wilson als Emily |
| Roy Pattison als Carroll |
| Victor Langley als Prince of Wales |
| Pamela Abbott als Princess Alexandra |
| Robin Marchal als Duke of Clarence |
| Richard Pescud als Doctor |
| Pat Brackenbury als Nurse |
| Dan Long als Constable Long |
 | Michael Cashman als Constable Watkins |
 | Tony Clarkin als Police Sergeant (uncredited) |
| Peter Dean als Police Constable (uncredited) |
 | Jim McManus als Policeman (uncredited) |
| Elwyn Jones | Novel |
| John Hopkins | Screenplay |
| Bob Clark | Director |
| Arthur Conan Doyle | Characters |
| John Lloyd | Novel |
| Carl Zittrer | Original Music Composer |
| Stan Cole | Editor |
| Paul Zaza | Original Music Composer |
| Reginald H. Morris | Director of Photography |
| David Wynn-Jones | Focus Puller |
| Ariel Levy | Assistant Director |
| Bob Clark | Producer |
| René Dupont | Producer |
| Robert A. Goldston | Producer |
| Len Herberman | Executive Producer |
| Karen Hazzard | Casting |
| Irene Lamb | Casting |
| Harry Pottle | Production Design |
| Denise Exshaw | Set Decoration |
| Judy Moorcroft | Costume Design |
| Colin Jamison | Hair Department Head |
| Peter Robb-King | Makeup Artist |
| Jane Royle | Makeup Artist |
| Jan Jamison | Assistant Hairdresser |
| Kenneth Heeley-Ray | Supervising Sound Editor |
| John Davis | Production Manager |
| Ted Rouse | Production Manager |
| Jimmy Turrell | Camera Operator |
| John W. Mitchell | Sound Recordist |
| Peter Childs | Art Direction |
| Joe Grimaldi | Sound Re-Recording Mixer |
| David Appleby | Sound Re-Recording Mixer |
| Ian McBride | Assistant Editor |
| Patrick Drummond | Sound Editor |
| Wayne Griffin | Sound Editor |
| Dennis Drummond | Sound Editor |
| Peter Robb-King | Makeup Supervisor |
| Ron Beck | Wardrobe Supervisor |
| Andy Birmingham | Production Accountant |
| Colin Jamison | Key Hairdresser |
| Ken Pattenden | Construction Manager |
| Michael Albrechtsen | Special Effects |
| Marjorie Lavelly | Continuity |
| Ray Meehan | Gaffer |
| Andy Andrews | Property Master |
| Denis Fraser | Grip |
| Janet Tebrooke | Wardrobe Master |
| Terry Lewis | Best Boy Grip |
| Guy Travers | Second Assistant Director |
| Ken Goch | Second Assistant Director |
| Liz Taylor | Production Secretary |
| Keith Pamplin | Boom Operator |
| Ron Butcher | Sound Engineer |
| Edward Morton | Wardrobe Assistant |
| Jan Jamison | Hair Assistant |
| Jock Kay | Scenic Artist |
| Lynda Levy | Unit Publicist |
| David Farrell | Still Photographer |
| Martin Ashbee | Assistant Sound Editor |
| Steven Cole | Assistant Sound Editor |
