 | Ioan Gruffudd als Reed Richards / Mr. Fantastic |
 | Jessica Alba als Sue Storm / Invisible Woman |
 | Chris Evans als Johnny Storm / Human Torch |
 | Michael Chiklis als Ben Grimm / The Thing |
 | Julian McMahon als Victor von Doom / Doctor Doom |
 | Hamish Linklater als Leonard |
 | Kerry Washington als Alicia Masters |
 | Laurie Holden als Debbie McIlvane |
 | David Parker als Ernie |
 | Kevin McNulty als Jimmy O'Hoolihan |
 | Maria Menounos als Sexy Nurse |
 | Michael Kopsa als Ned Cecil |
 | Andrew Airlie als Compound Doctor |
 | Pascale Hutton als Nightclub Girlfriend |
 | G. Michael Gray als Nightclub Boyfriend |
 | David Richmond-Peck als Gallery Patron |
 | Penelope Parkes als Bohemian Girl 1 |
 | Aonika Laurent als Bohemian Girl 2 |
 | Jason Schombing als Bridge Businessman |
 | Jason Diablo als NYPD Bridge Cop 1 |
 | Colin Lawrence als NYPD Bridge Cop 2 |
 | Paul Belsito als NYPD Bridge Cop 3 |
 | Dee Jay Jackson als Chief Fireman |
| Morgan Reynolds als Corvette Redhead |
 | Gina Holden als LV Receptionist |
 | Donavon Stinson als X Games Announcer |
 | Douglas Weston als Victor's Doctor |
 | Tony Alcantar als Compound Reporter #1 |
 | Brenda Crichlow als Compound Reporter #2 |
 | Peter Bryant als Lame Joke Businessman |
 | Lorena Gale als Old Lady With Car #1 |
| Danielle Dunn-Morris als Old Lady With Car #2 |
 | Nicole Muñoz als Little Girl |
 | Daniel Bacon als Bridge Reporter |
| Bobby Bysouth als Compound Reporter #3 |
 | Kenny Bartram als Himself |
| Ronnie Renner als Himself |
 | Brian Deegan als X Games Rider |
 | Marlaina Mah als Lusting Model |
| Tre Verhoeven als Lusting Model |
| Juanita Mirehouse als Lusting Model |
| Stefanie Singer als Lusting Model |
 | Jamie Little als X Games Reporter |
 | Doug Abrahams als Truck Driver |
 | Ron Chartier als Hotel Guest |
 | Stan Lee als Willie Lumpkin |
| Barbara Christabella als Girl in Park |
| Sanja Banic als Girl in Park |
| Ed Hodson als Construction Worker |
 | John Speredakos als Construction Worker |
 | Jason Kaufman als Cop |
| Preston Thomas Peet als Goth Guy |
| Steven Fulani Hart als Newsstand Pedestrian |
| Bethann Schebece als Newsstand Pedestrian |
| Lou Torres als Cab Driver |
 | Peggy Gormley als Homeless Woman |
| Maurice Tyson als Homeless Guy |
| Jaimie McVittie als Little Girl On Bridge |
| Jenni Squair als Elevator Lady |
| Lia Salmond als Elevator Lady |
 | Ellen Ewusie als Elevator Lady |
 | Ylenia Aurucci als Elevator Lady |
| Michelle Zembruski als Elevator Lady |
| Kathleen Mullan als Elevator Lady |
| Georgia Dewson als Elevator Lady |
| Sienna Rose als Storm's Fan |
| Hector A. Leguillow als Newsstand Vendor |
 | Ben Mulroney als Etalk Daily CTV |
 | Terry David Mulligan als CityTV |
 | Lauren Sánchez als KCOP / KTTV |
| Mark S. Allen als KMAX-TV(IND) Sacramento |
| Jon Brady als Fox Network News |
| Taryn Winter Brill als Aol.com |
| Sara Edwards als The Comcast Network |
| Heidi Eng als King-TV(NBC) Seattle |
| Jim Ferguson als ABC-KGUN 9-TV Tucson |
| Sam Hallenbeck als NBC Tampa |
| Mike Waco als Fox Network News |
| Marian Etoile Watson als UPN 9 / Fox |
| Richard Ho als Wizard: The Comics Magazine |
| Dave Holmes als FX |
| Andrew Hunsaker als Yahoo Entertainment |
| Taylor Johnson als MSN.com |
| Bonnie Laufer-Krebs als Tribute TV |
| Lisa Fuller Magee als KTVK-TV(IND) Phoenix |
| Bret Martin als Fox 5 / WAGA Atlanta |
| Liam Mayclem als KRON-TV(IND) San Francisco |
| Scott Patrick als KUSA-TV(NBC) Denver |
| Shaheem Reid als MTV News |
| Sam Rubin als KTLA |
| Maria Salas als NBC Entertainment Reporter Miami |
| Devon Soltendieck als MuchMusic |
| Patrick Stoner als WHYY-TV Philadelphia |
| Lee Thomas als Fox 2 Detroit |
| Tony Toscano als Talking Pictures / KJZZ-TV(IND) Salt Lake City |
| Jennifer Lothrop als FX |
| Lorna Joan Barrie als Woman on bridge (uncredited) |
 | Doug Chapman als Fireman Hanging Off Bridge (uncredited) |
| Sean Bennett als Newsstand Pedestrian (uncredited) |
 | Christopher Gordon als Fireman (uncredited) |
| Richard Rigby als Cafe Patron / Party Goer (uncredited) |
 | Yvonne Myers als Principal (uncredited) |
 | Ralph Winter als Ship Worker (uncredited) |
 | Lynnanne Zager als Computer (voice) (uncredited) |
| Avi Arad | Producer |
| Michael Barnathan | Executive Producer |
| Chris Columbus | Executive Producer |
| Bernd Eichinger | Producer |
| Kevin Feige | Executive Producer |
| Stan Lee | Executive Producer |
| Mark Radcliffe | Executive Producer |
| Ralph Winter | Producer |
| John Ottman | Original Music Composer |
| Oliver Wood | Director of Photography |
| William Hoy | Editor |
| Tim Story | Director |
| Jack Kirby | Comic Book |
| Bill Boes | Production Design |
| Lee Cleary | Associate Producer |
| Ross T. Fanger | Co-Producer |
| David Gorder | Associate Producer |
| Kurt Williams | Associate Producer |
| Nancy Klopper | Casting |
| Mark Frost | Writer |
| Michael France | Writer |
| Stan Lee | Comic Book |
| Shepherd Frankel | Supervising Art Director |
| Don MacAulay | Art Direction |
| Elizabeth Wilcox | Set Decoration |
| Jose Fernandez | Costume Design |
| Rikki Gagne | Stunts |
| Mark N. Tompkins | Painter |
| Lee Anne Elaschuk | Art Department Assistant |
| Lisa Leung | Art Department Coordinator |
| Mira Caveno | Assistant Art Director |
| Constantine Sekeris | Conceptual Design |
| Jonas Kirk | Construction Coordinator |
| Lynn Chaulk | Lead Painter |
| Margareth Lynch | Line Producer |
| Brent Boates | Production Illustrator |
| Chet Zar | Sculptor |
| Zoe Jirik | Set Decoration Buyer |
| Nancy Anna Brown | Set Designer |
| Mark Chow | Additional Camera |
| Paul Mitchnick | Camera Operator |
| Steven J. Winslow | Camera Technician |
| Aristidi Georgiopoulos | First Assistant Camera |
| Steve Smith | Key Grip |
| Mike West | Grip |
| Richard Roles | Aerial Director of Photography |
| Jim Van Dijk | Steadicam Operator |
| Kerry Hayes | Still Photographer |
| Ann Foley | Assistant Costume Designer |
| James W. Tyson | Costume Supervisor |
| Elke Gordon | Hairstylist |
| Anji Bemben | Key Hair Stylist |
| Kathryn Bihr | Makeup Artist |
| Patti Bishop | Set Costumer |
| Keith Burk | Set Dressing Artist |
| Stacey Butterworth | Wigmaker |
| Derek Del Puppo | Carpenter |
| Mike Hardison | CG Supervisor |
| Bob Bedard | Chef |
| Steven Wargo | Craft Service |
| Susan Hegarty | Dialect Coach |
| Andre Bustanoby | Digital Effects Supervisor |
| Dave Miller | Driver |
| Audrey Dennison | Loader |
| Jamie Clarke | Post Production Assistant |
| Patrick Esposito | Post-Production Manager |
| Charlie Davis | Post Production Supervisor |
| Sid Nicholson | Propmaker |
| James H. Chow | Property Master |
| John B. Keys | Scenic Artist |
| Martineau David | Security |
| Stefan Herz | Software Engineer |
| Tim Gomillion | Sound Recordist |
| Steven Kirshoff | Special Effects Coordinator |
| Zack Abramowitz | Stand In |
| John Branagan | Stunt Coordinator |
| Dave Alexander | Stunts |
| Bill Haller | Supervising Animator |
| Devin Bunje | Systems Administrators & Support |
| David Holm | Transportation Captain |
| Scott Irvine | Transportation Coordinator |
| Ross T. Fanger | Unit Production Manager |
| Joe Everett | Unit Publicist |
| Leslie McMichael | Utility Stunts |
| Rob Graham | Video Assist Operator |
| Peter S. Elliot | Visual Effects Editor |
| Lee Cleary | First Assistant Director |
| Jigesh Gajjar | Layout |
| Jim Passon | Color Timer |
| Breanne Larrett | Editorial Production Assistant |
| Danny Rafic | First Assistant Editor |
| Doug Dalisera | Best Boy Electric |
| Peter Ronan | Electrician |
| Dennis Brock | Gaffer |
| Jonathan Germain | Lighting Artist |
| James S. Harvey | Lighting Technician |
| Jarrod Tiffin | Rigging Gaffer |
| Errin Lally | Casting Associate |
| Damon Michael Gordon | Location Manager |
| Maryjane Layani | Production Accountant |
| Rebecca Adams | Production Coordinator |
| Stewart Bethune | Production Manager |
| Brian Walsh | Production Supervisor |
| Jim Brookshire | ADR Supervisor |
| Chris Glyn-Jones | Boom Operator |
| Skip Longfellow | First Assistant Sound Editor |
| Amanda Goodpaster | Music Editor |
| Dave Jordan | Music Supervisor |
| Eric Batut | Production Sound Mixer |
| Casey Stone | Scoring Mixer |
| Charles Maynes | Sound Designer |
| Phil Jeffers | Sound Editor |
| Erik Aadahl | Sound Effects Editor |
| John A. Larsen | Supervising Sound Editor |
| Paul Griffin | Animatronics Supervisor |
| David Zbriger | I/O Supervisor |
| Tommy Frazier | Special Effects Supervisor |
| Alp Altiner | Visual Effects |
| Dean Gula | Visual Effects Coordinator |
| Melissa Brockman | Visual Effects Producer |
| Berj Bannayan | Visual Effects Supervisor |
| Eric Clement | Sequence Leads |
| Amy Beresford | Digital Producer |
| Kent Beyda | Additional Editing |
| Yvonne Melville | Unit Manager |
| James Start | Thanks |
| Matthew Adams | Digital Compositors |
| Diego Garzon | Script Supervisor |
| Susan Dawes | Dialogue Editor |
| Helen Luttrell | Dialogue Editor |
| Dennis Rogers | Sound Recordist |
| Tim Maxwell | Sound Recordist |
| Mike Carpenter | Rigging Grip |
| Tamar Ouziel | Assistant Makeup Artist |
| Michelle Baines | Costume Set Supervisor |
| Rena Campbell | Costumer |
| Wendy Snowdon | First Assistant Makeup Artist |
| Dawn Y. Line | Key Costumer |
| Mike Elizalde | Makeup Supervisor |
| Andre Brouwer | Truck Costumer |
| Lance Peverley | Additional Third Assistant Director |
| Catherine Kretz | Second Second Assistant Director |
| Brian Smrz | Second Unit Director |
| Ashley Bell | Third Assistant Director |
| Jason B. Landels | Assistant Property Master |
| Patrick Janicke | Concept Artist |
| Warren Flanagan | Conceptual Illustrator |
| Sharon Dever | Construction Buyer |
| Julio Ferrario | Creative Director |
| Leah Hong | Graphic Designer |
| Dave Emmonds | Head Greensman |
| Claudio Palavecino | On Set Props |
| Herminio Kam | Paint Coordinator |
| Niles Heckman | Set Supervisor |
| Trevor Goring | Storyboard Artist |
| Derek Casari | ADR Engineer |
| Charleen Richards-Steeves | ADR Mixer |
| David Lucarelli | ADR Recordist |
| James Bolt | Additional Sound Re-Recording Mixer |
| John T. Cucci | Foley Artist |
| James Ashwill | Foley Mixer |
| John Murray | Foley Supervisor |
| Blake R. Cornett | Second Assistant Sound |
| Chris Higgins | Sound Assistant |
| Miki Bang | Special Effects Assistant |
| Colin Naso | Special Effects Best Boy |
| Dennis Briest | Special Effects Technician |
| Jeffrey A. Okun | Additional Visual Effects |
| Anthony Alvaro | Visual Effects Production Assistant |
| Garvin Cross | Stunt Double |
| Ed Anders | Stunt Driver |
| Jim Van Dijk | First Assistant "A" Camera |
| Richard Porta | Assistant Camera |
| Paul Arnel | Best Boy Grip |
| Scott Koenigsberg | Camera Loader |
| Vince Krochak | Camera Trainee |
| Reid Cohoon | Dolly Grip |
| Larry Portmann | Focus Puller |
| Joe Buxton | Libra Head Technician |
| Justin Bergler | Second Assistant Camera |
| Joshua Cordes | Senior Animator |
| Caitlin McKenna | ADR Voice Casting |
| Susan Paley Abramson | Casting Assistant |
| Caroline Hardon | Assistant Editor |
| Sean Lawrence | Colorist |
| Ron Barr | Digital Intermediate Editor |
| Chris Holt | Digital Intermediate Producer |
| Gary Burritt | Negative Cutter |
| Jason Farrar | Assistant Location Manager |
| Alex Borys | Location Assistant |
| Josh Pickens | Location Production Assistant |
| Damon Intrabartolo | Conductor |
| Jojo Villanueva | Music Coordinator |
| Steve Flynn | Aerial Coordinator |
| Paul Jasper | Animal Coordinator |
| Amanda Bronswyk | Assistant Accountant |
| Brian Emerson | CG Artist |
| Patrick Flanagan | Compositing Artist |
| Kathryn Bolt | Compositing Supervisor |
| Alexandra Altrocchi | Digital Effects Producer |
| Greg Gladstone | Effects Supervisor |
| Andrea Brown | Extras Casting |
| Ali Merhi | Extras Casting Assistant |
| Christian Feldhaus | First Assistant Accountant |
| Jay Anderson | Generator Operator |
| Francois Garcia | Head of Production |
| Vincent Dela Luna | Key Production Assistant |
| Kent Matheson | Matte Painter |
| Jim Filippone | Pilot |
| Tana Tocher | Production Driver |
| David Ebner | Production Executive |
| Tim Coleman | Rigging Supervisor |
| Richard Wynnyk | Security Coordinator |
| Melissa Crich | Travel Coordinator |
| Ray McIntyre Jr. | Digital Effects Supervisor |
| John 'D.J.' Des Jardin | Visual Effects Supervisor |
| Jeff Miller | Production Assistant |
| Kylie Furneaux | Stunts |
| Marny Eng | Stunts |
| Rick Pearce | Stunts |
| Crystal Dalman | Stunts |
| Chris Palermo | Stunts |
| Monique Ganderton | Stunts |
| Andrea Kinsky | Stunts |
| Brett Armstrong | Stunt Double |
| Krista Bell | Stunts |
| Owen Walstrom | Stunt Coordinator |
| Dane Farwell | Stunts |
| Ashlea Earl | Stunts |
| Celia Bond | Stunts |
| Ed Anders | Stunts |
| Carolyn Anderson | Stunts |
| Charles Andre | Stunts |
| Aaron Au | Stunts |
| Scott J. Ateah | Stunts |
| Shawn Beaton | Stunts |
| Chad Bellamy | Stunts |
| Guy Bews | Stunts |
| Curt Bonn | Stunts |
| Duane Bradley | Stunts |
| Jake Brake | Stunts |
| Byron Brisco | Stunts |
| Gavin Buhr | Stunts |
| Leanne Buchanan | Stunts |
| Dave Campbell | Stunts |
| Jason Calder | Stunts |
| Kirk Caouette | Stunts |
| Clint Carleton | Stunts |
| Brett Chan | Stunts |
| Raymond Chan | Stunts |
| Alex Chiang | Stunts |
| Susan Charest | Stunts |
| Kimberly Chiang | Stunts |
| Doug Chapman | Stunts |
| Nesta Chapman | Stunts |
| Laura Lee Connery | Stunts |
| Doug Coombs | Stunts |
| Brent Connolly | Stunts |
| Mike Crestejo | Stunts |
| Mike Ching | Stunts |
| Mike Dopud | Stunts |
| Jayson Dumenigo | Stunts |
| Ryan Ennis | Stunts |
| Bill Ferguson | Stunts |
| Glenn Ennis | Stunts |
| Caroline Field | Stunts |
| Rob Fournier | Stunts |
| Alette Falle | Stunts |
| Bruce Fontaine | Stunts |
| Jason Glass | Stunts |
| Lani Gelera | Stunts |
| Christopher Gordon | Stunt Double |
| Lars Grant | Stunts |
| Mike Godenir | Stunts |
| Regis Harrington | Stunts |
| Robert Hayley | Stunts |
| Braden Haggerty | Stunts |
| Adrian Hein | Stunts |
| Dave Hospes | Stunts |
| Curtis Hibbert | Stunts |
| Kathy Hubble | Stunts |
| Kim Howey | Stunts |
| Ernie Jackson | Stunts |
| Lisa Korthals | Stunts |
| Jon Kralt | Stunts |
| David Jacox | Stunts |
| Randy Lee | Stunts |
| Jake Lombard | Stunts |
| Cody Laudan | Stunts |
| Jaimie McVittie | Stunts |
| Mike Mitchell | Stunts |
| Brian Machleit | Stunts |
| Steven McMichael | Stunts |
| Seth Longworth | Stunts |
| Leslie McMichael | Stunts |
| Scott Nicholson | Stunts |
| Ron Otis | Stunts |
| Frédéric North | Stunts |
| Jamie Payton | Stunts |
| Gerald Paetz | Stunts |
| Dan Redford | Stunts |
| James Ralph | Stunts |
| Jeffrey C. Robinson | Stunts |
| Raymond Sammel | Stunts |
| Darryl Scheelar | Stunts |
| Jeff Sanca | Stunts |
| Chris Sayour | Stunts |
| Todd Scott | Stunts |
| Dan Shea | Stunts |
| Ryan Schroeder | Stunts |
| Larry M. Shorts | Stunts |
| Kymberly Sheppard | Stunts |
| Kimani Ray Smith | Stunts |
| Frank Torres | Stunts |
| Sharon Simms | Stunts |
| Heath Stevenson | Stunts |
| Rorelee Tio | Stunts |
| Monte Thompson | Stunts |
| Angela Uyeda | Stunts |
| Leah Wagner | Stunts |
| John Wardlow | Stunts |
| Marshall Virtue | Stunts |
| Chris Webb | Stunts |
| Claire Webb | Stunts |
| Merritt Yohnka | Stunts |
| Rob Wilton | Stunts |
| Kai Nuuhiwa | Stunts |
| Jennifer Mylrea | Stunts |
| Brian Ho | Stunts |
