 | Owen Wilson als Rick Mills |
 | Jason Sudeikis als Fred Searing |
 | Jenna Fischer als Maggie Mills |
 | Christina Applegate als Grace Searing |
 | Nicky Whelan als Leigh |
 | Richard Jenkins als Coakley |
 | Stephen Merchant als Gary |
 | Larry Joe Campbell als Hog-Head |
 | Bruce Thomas als Rick Coleman |
 | Tyler Hoechlin als Gerry |
 | Derek Waters als Brent |
 | Alexandra Daddario als Paige |
 | Rob Moran als Ed Long |
 | Lauren Bowles als Britney |
 | Christa Beth Campbell als Emma |
 | Macsen Lintz als Gunnar |
 | Kristin Carey als Aunt Meg |
 | Joy Behar als Dr. Lucy |
 | Carly Craig als Nicotine Patch Girl |
 | Kaliko Kauahi als Chief |
 | Landon T. Riddle als Ed's Son |
| Halli-Gray Beasley als Ed's Daughter |
 | J.B. Smoove als Flats |
 | Vanessa Angel als Missy Frankinopoulos |
 | Andrew Wilson als Larry Bohac |
 | Alyssa Milano als Mandy |
 | Danny Murphy als Boshane |
| Al Wisne als Clyde |
 | Mike Meldman als Michael Meldman |
| Susan Sandberg als Doctor |
| Dwight Evans als Maggie's Father |
 | Shannon Leade als 20-Something Woman |
| Gus Williams als Bouncer |
 | Gordon Danniels als Golf Ranger |
| Jamie Lee als Dry Clean Korean Lady |
 | Quynh Thi Le als Young Korean Woman |
| Robert Flaherty als Awards Dinner Bartender |
| Matt Fairbairn als Harold Goldberg |
 | Doris Morgado als Latino Woman #1 |
| Maria Duarte als Latino Woman #2 |
| Thaddeus Rahming als Naked Guy #1 |
| Rich Brown als Naked Guy #2 |
| Jeff Norton als Lake Cop #1 |
| Terry Mullany als Lake Cop #2 |
| Brian Mone als Honorable Judge William Mone |
 | Taylor Treadwell als Young Bride (Emma) |
| Craig X. Scott als Older Gunnar |
| Kathryn Kim als Another Korean Woman |
| Richard Melton als Burly Cop |
 | Edward Barbanell als Coach Eddie |
| Romy Wang als Woman Golfer #1 |
| Suki Frick als Woman Golfer #2 |
| Soon Yup Han als Woman Golfer #3 |
| Cristina Nardozzi als Girl in Restaurant |
| Ezra Neo Dierking als Party Boy |
 | Bo Burnham als Bartender |
 | Mike Cerrone als Driver Cop |
 | Zen Gesner als Passenger Cop |
 | Kristyl Dawn Tift als Gary's Wife |
 | Daniel Greene als Officer #1 |
 | Patricia French als Officer #2 |
| Bob Weekes als Bar Manager |
| Stella Barrow als Stella Bass Band |
| Willie Barrow als Stella Bass Band |
| Jikker Barrow als Stella Bass Band |
| Ron Brown als Stella Bass Band |
| Meredith Oliver Oglesby als Bar Patron Meredith |
| Candice Ozechowski als Bar Patron Candice |
| Lee Anne Freeman als Bar Patron Lee Anne |
| Christina Avalos als Bar Patron Christina |
| Igor Vovkovinskiy als Johnny's Hideaway Tall Stud |
 | Chloe Snyder als Stootfish Babe |
 | Kathy Griffin als Kathy Griffin |
 | A.B. Cassidy als Backyard BBQ Friend |
 | Wen Yann Shih als Asian Woman |
 | Tom Choi als Asian Husband |
| Juan Qian als Elderly Asian Woman |
| Jesse Farrelly als Witness on Roof |
| Bobby Farrelly | Director |
| Peter Farrelly | Director |
| Pete Jones | Screenplay |
| Peter Farrelly | Screenplay |
| Pete Jones | Story |
| Bobby Farrelly | Screenplay |
| Kevin Barnett | Screenplay |
| Rick Montgomery | Casting |
| Matthew F. Leonetti | Director of Photography |
| Sam Seig | Editor |
| Arlan Jay Vetter | Production Design |
| Denise Wingate | Costume Design |
| Dan Morski | Art Direction |
| Cindy Carr | Set Decoration |
| Tom Wolfe | Music Supervisor |
| Manish Raval | Music Supervisor |
| Ronald J. Webb | Music Editor |
| Andrew DeCristofaro | Supervising Sound Editor |
| Michael Payne | Supervising Sound Effects Editor |
| Peter Iovino | Still Photographer |
| Martin Kitrosser | Script Supervisor |
| Hope Slepak | Costume Supervisor |
| Stacie McKinnon | Art Department Coordinator |
| Joani Yarbrough | Hair Department Head |
| Sarah Mays | Makeup Department Head |
| Bobby Farrelly | Producer |
| Peter Farrelly | Producer |
| Charles B. Wessler | Producer |
| Bradley Thomas | Producer |
| Toby Emmerich | Executive Producer |
| Marc S. Fischer | Executive Producer |
| Merideth Finn | Executive Producer |
| Richard Brener | Executive Producer |
| Mark Charpentier | Co-Producer |
| John Rickard | Co-Producer |
| J.B. Rogers | Co-Producer |
| Kris Meyer | Co-Producer |
| Ellen Dumouchel | Associate Producer |
| Day Permuy | Production Coordinator |
| Nancy Nugent | Supervising Dialogue Editor |
| Nancy Nugent | Supervising ADR Editor |
| John C. Stuver | Dialogue Editor |
| Michael Sabo | Property Master |
| Stephen P. Robinson | Sound Effects Editor |
| George Haddad | Sound Effects Editor |
| Steve Nelson | Sound Effects Editor |
| Glynna Grimala | Sound Effects Editor |
| Drew Ponder | Boom Operator |
| Richard Malzahn | Visual Effects Supervisor |
| Brian Drewes | Visual Effects Producer |
| Mary Stuart | Visual Effects Producer |
| Tierre Turner | Stunt Coordinator |
| Jacques Jouffret | Camera Operator |
| Michael St. Hilaire | Camera Operator |
| Marc S. Fischer | Unit Production Manager |
| J.B. Rogers | First Assistant Director |
| Greg Guzik | Second Assistant Director |
| John Cenatiempo | Stunts |
| Madison Turner | Stunts |
| Matt McColm | Stunts |
| Richard Bucher | Stunts |
| Jay Pearson | Stunts |
| Jonathan Arthur | Stunts |
| Haley Nott | Stunts |
| Ashley Rae Trisler | Stunts |
| Anderson Martin | Stunts |
| Todd Warren | Stunts |
| Jason Silvis | Stunts |
| Scott Dale | Stunts |
| Michael Trisler | Stunts |
| Dain Turner | Stunts |
| Connor O'Malley | Stunts |
| Adam McCarthy | Production Supervisor |
| Jeffrey N. Civa | First Assistant Camera |
| Trey Twitty | Second Assistant Camera |
| Hugh Braselton | Second Assistant Camera |
| Mary H. Ellis | Production Sound Mixer |
| Robert Carnevale | Additional Camera |
| C. Alan Rawlins Sr. | Key Grip |
| Riko Schatke | Best Boy Grip |
| Gary Kelso | Dolly Grip |
| Darryl Humber | Dolly Grip |
| Fred L. McLane | First Assistant Camera |
| Mike Tyson | Rigging Gaffer |
| Dan Cornwall | Chief Lighting Technician |
| Patty York | Makeup Artist |
| Susan Ransom | Key Makeup Artist |
| Stephanie Ponder | Makeup Artist |
| Nico Sohn | Makeup Artist |
| Geraldine Jones | Hairstylist |
| Vanessa Davis | Key Hair Stylist |
| T.A. Henderson | Hairstylist |
| Linda Thompson | Hairstylist |
| Shawn M. Gray | Assistant Property Master |
| Sarah Downer | Costumer |
| Heather Sease | Costumer |
| Sandra Collier | Costumer |
| Kate Duke | Set Costumer |
| K. Drew Fuller | Set Costumer |
| Elizabeth McEntire Williams | Set Costumer |
| Robert Vazquez | Special Effects Coordinator |
| Larry Madaras | Additional Editor |
| David Raymond | First Assistant Editor |
| Patrick Cusack | Foley Editor |
| Fernand Bos | Supervising Music Editor |
| Jonathan Leahy | Music Coordinator |
| Brad Sherman | Sound Re-Recording Mixer |
| Steve Pederson | Sound Re-Recording Mixer |
| Thomas J. O'Connell | ADR Mixer |
| John Roesch | Foley Artist |
| Alyson Dee Moore | Foley Artist |
| Sheila Allen | Production Accountant |
| Haley Billue | Production Secretary |
| Maida N. Morgan | Location Manager |
| Stephen Dirkes | Assistant Location Manager |
| Robert Brubaker | Transportation Captain |
| Bob Foster | Transportation Coordinator |
| Erin G. Fuller | Location Coordinator |
| Masako Masuda | Set Designer |
| Burt Welleford | Swing |
| Jay Womer | Construction Coordinator |
| John M. Pisani | Unit Publicist |
| Jason James | Casting Associate |
| Mark Steilen | Second Unit Director |
| Gary Burritt | Negative Cutter |
| Mark Keever | Set Dresser |
| Andy Rusk | Set Dresser |
| Ryan Kutch | Set Dresser |
| Javed Noorullah | Set Dresser |
| James Vasilovic | Set Dresser |
| Shane Reed | Leadman |
| John Bonaccorse | Second Second Assistant Director |
