 | Daniel Craig als James Bond |
 | Léa Seydoux als Dr. Madeleine Swann |
 | Rami Malek als Lyutsifer Safin |
 | Lashana Lynch als Nomi |
 | Ralph Fiennes als M |
 | Ben Whishaw als Q |
 | Naomie Harris als Eve Moneypenny |
 | Jeffrey Wright als Felix Leiter |
 | Ana de Armas als Paloma |
 | Billy Magnussen als Logan Ash |
 | Christoph Waltz als Ernst Stavro Blofeld |
 | Rory Kinnear als Bill Tanner |
 | David Dencik als Valdo Obruchev |
 | Dali Benssalah als Primo (Cyclops) |
 | Lisa-Dorah Sonnet als Mathilde |
| Coline Defaud als Young Madeleine |
| Mathilde Bourbin als Madeleine's Mother |
 | Hugh Dennis als Dr. Hardy |
 | Priyanga Burford als Dr. Symes |
 | Joe Grossi als Hotel Porter |
| Nicola Olivieri als Cemetery Caretaker |
 | Pio Amato als Cemetery Attendant |
 | Javone Prince als MI6 Security Guard |
 | Davina Moon als Madeleine's Receptionist |
| Mattia Lacovone als Young Shepherd |
| Giansalvatore Duca als Young Shepherd |
 | Amy Morgan als Alison Smith |
 | Lizzie Winkler als Sarah Jones |
 | Andrei Nova als Bunker Guard |
 | Ernest Gromov als Bunker Guard |
 | Gediminas Adomaitis als Blofeld's Right Hand Man |
 | Andy Cheung als Chinese Businessman |
 | Brigitte Millar als Vogel |
| Hayden Phillips als Sir Sebastian D'ath |
 | Winston Ellis als Spectre Agent |
| Adnan Rashed als Spectre Agent |
| Rae Lim als Spectre Agent |
| Chi Chan als Spectre Agent |
 | Denis Khoroshko als Spectre Agent |
 | Lourdes Faberes als Spectre Agent |
 | Philip Philmar als Spectre Agent |
 | Raymond Waring als Spectre Agent |
 | Eliot Sumner als Spectre Guard |
 | Rod Hunt als Spectre Guard |
 | Michael Mercer als El Nido Bartender |
| Gemmar Mcfarlane als Passersby |
| Leighton Laing als Passersby |
| Kimo Armstrong als Passersby |
 | Gordon Alexander als Lab Technician (uncredited) |
 | Steve Barnett als Spectre Agent (uncredited) |
 | Tuncay Gunes als Spectre Agent (uncredited) |
 | Clem So als Spectre Agent (uncredited) |
 | Ahmed Bakare als Spectre VIP Guest (uncredited) |
| Douglas Bunn als Spectre Member (uncredited) |
 | Toby Sauerback als Guard (uncredited) |
| Zoltan Rencsar als Spectre Bodyguard (uncredited) |
| John Farrer als Casino Player (uncredited) |
| Paul O'Kelly als Safin Henchman (uncredited) |
 | Michael G. Wilson als Spectre Party Guest (uncredited) |
| Michael Herne als Spectre Guest (uncredited) |
| Julian Ferro als MI6 Security Guard (uncredited) |
| Ross Donnelly als Hotel Guest (uncredited) |
| Cary Joji Fukunaga | Director |
| Linus Sandgren | Director of Photography |
| Elliot Graham | Editor |
| Tom Cross | Editor |
| Debbie McWilliams | Casting |
| Sandra Phillips | Art Direction |
| Véronique Melery | Set Decoration |
| Bryan Bowen | Sound Designer |
| Tom Barrow | Sound Mixer |
| Alan Hill | Sound Mixer |
| Gregg Wilson | Associate Producer |
| Suttirat Anne Larlarb | Costume Design |
| Andrew Noakes | Co-Producer |
| Mark Harris | Art Direction |
| Michael G. Wilson | Producer |
| Chris Brigham | Executive Producer |
| Neal Callow | Art Direction |
| Enzo Sisti | Line Producer |
| Per Henry Borch | Line Producer |
| Andrew Bennett | Art Direction |
| Dean Clegg | Art Direction |
| Barbara Broccoli | Producer |
| Mark Tildesley | Production Design |
| Hans Zimmer | Original Music Composer |
| Robert Wade | Screenplay |
| Phoebe Waller-Bridge | Screenplay |
| Cary Joji Fukunaga | Screenplay |
| Neal Purvis | Screenplay |
| Daniel Craig | Co-Producer |
| Arran Brownlee | Concept Artist |
| Buddie Wilkinson | Standby Property Master |
| Karl Jordan | Special Effects Technician |
| Steve Mazzaro | Additional Music |
| James Harrison | Supervising Sound Editor |
| Marzenna Fus-Mickiewicz | Makeup Artist |
| Rachel Lennon | Makeup Artist |
| Hugo Adams | Foley Supervisor |
| Mark Appleby | ADR Mixer |
| Kristin Catuogno | ADR Recordist |
| Mark DeSimone | ADR Mixer |
| Aidan Dykes | ADR Recordist |
| Adele Fletcher | Dialogue Editor |
| Dawn Gough | Sound Effects Editor |
| Sue Harding | Foley Artist |
| Yoshi DeHerrera | Visual Effects Supervisor |
| Gerard Diefenthal | Visual Effects Supervisor |
| François Lambert | Visual Effects Supervisor |
| Mark Bakowski | Visual Effects Supervisor |
| Matteo Veglia | VFX Production Coordinator |
| Ian Fleming | Characters |
| Cary Joji Fukunaga | Story |
| Neal Purvis | Story |
| Robert Wade | Story |
| Jamie Hearing | VFX Artist |
| Tamara Marini | Art Direction |
| Roxana Alexandru | Assistant Art Director |
| Rupert Hancock | Set Dresser |
| Chris Lowe | Supervising Art Director |
| Hugh McClelland | Assistant Art Director |
| Romolo Pompa | Assistant Art Director |
| Laraib Atta | Digital Compositor |
| Daniel Kleinman | Main Title Designer |
| Lynn Jackett | Makeup Artist |
| Mia Hope Radford | Set Costumer |
| Sarah Robinson | Costume Supervisor |
| Paul Massey | Sound Re-Recording Mixer |
| Oliver Tarney | Supervising Sound Editor |
| Mark Taylor | Sound Effects Editor |
| Mark Taylor | Sound Re-Recording Mixer |
| Richard Bain | Visual Effects Supervisor |
| Tommy Barry | VFX Artist |
| Sreekanth Boyapati | Visual Effects |
| Mara Bryan | Visual Effects Producer |
| Michael Cashmore | VFX Artist |
| Sanchia Currie | Visual Effects Producer |
| Jonathan Fawkner | Visual Effects Supervisor |
| Daniel Hazeltine | VFX Artist |
| Russell Hopwood | Visual Effects |
| Ondrej Hudecek | VFX Artist |
| Tracy Nicole Irwin | VFX Artist |
| Anna V. James | Visual Effects Producer |
| Nick King | Visual Effects |
| Toby Lewin | VFX Artist |
| Benjamin Loch | Visual Effects Supervisor |
| Yael Majors | Visual Effects Supervisor |
| Owen McGonigle | VFX Artist |
| Aileen Mu | Visual Effects Producer |
| Charlie Noble | Visual Effects Supervisor |
| Imran Ahmed Raichuri | VFX Artist |
| Mnandi Ridley | VFX Artist |
| Rob Shears | Visual Effects Producer |
| Shubham Singh Rathore | VFX Artist |
| Loeng Wong-Savun | VFX Artist |
| Raffaella Cuviello | Set Decoration Buyer |
| Arwel Evans | Standby Art Director |
| Liam Georgensen | Assistant Art Director |
| Charlotte Leatherland | Assistant Art Director |
| Luke Whitelock | Assistant Art Director |
| Sami Fendall | Scenic Artist |
| Nina Jalava | Stand In |
| Pedro Eustache | Musician |
| Reetu Aggarwal | 3D Artist |
| Emily Thomas | Third Assistant Director |
| Alexander Witt | Second Unit Director |
| Jessica Hooker | Stunt Double |
| Elizabeth Donker Curtius | Stunt Double |
| Maria Gnecchi | Stunts |
| Tolga Kenan | Stunts |
| Marc Mailley | Stunts |
| Nikita Mitchell | Stunt Double |
| Matthew Sharp | Assistant Director |
| Martin Gordon | Stunts |
| Simon Hayes | Production Sound Mixer |
| Billie Eilish | Main Title Theme Composer |
| Finneas O'Connell | Main Title Theme Composer |
| Billie Eilish | Theme Song Performance |
| Martin Bell | Pre-Visualization Supervisor |
