 | Mia Wasikowska als Alice Kingsleigh |
 | Johnny Depp als Mad Hatter |
 | Anne Hathaway als White Queen |
 | Helena Bonham Carter als Red Queen |
 | Alan Rickman als Blue Caterpillar (voice) |
 | Michael Sheen als White Rabbit (voice) |
 | Sacha Baron Cohen als Time |
 | Andrew Scott als Addison Bennett |
 | Rhys Ifans als Zanik Hightopp |
 | Timothy Spall als Bayard (voice) |
 | Ed Speleers als James Harcourt |
 | Stephen Fry als Cheshire Cat (voice) |
 | Lindsay Duncan als Helen Kingsleigh |
 | Matt Lucas als Tweedledee / Tweedledum |
 | Tom Godwin als Pimlick Hightopp |
 | Richard Armitage als King Oleron |
 | Amelia Crouch als Young Mirana |
 | Leilah de Meza als Young Iracebeth |
 | Geraldine James als Lady Ascot |
 | Leo Bill als Hamish |
 | Barbara Windsor als Mallykun (voice) |
 | Meera Syal als Nobody (voice) |
 | Hattie Morahan als Queen Elsemere |
 | Simone Kirby als Tyva Hightopp |
 | Siobhan Redmond als Bumalig Hightopp |
 | Paul Whitehouse als Thackery (voice) |
 | Matt Vogel als Wilkins (voice) |
 | Paul Hunter als Chess King (voice) |
 | Wally Wingert als Humpty Dumpty (voice) |
 | Louis Ashbourne Serkis als Young Hatter |
 | Joanna Bobin als Alexandra |
 | Joe Hurst als Bim Hightopp |
| Oliver Hawkes als Young Bim Hightopp |
 | Frederick Warder als Poomally Hightopp |
| Eve Hedderwick Turner als Paloo Hightopp |
 | Daniel Hoffmann-Gill als Boatswain |
 | Jamie Baughan als First Mate |
| Matt Wilman als Helmsman |
 | Siobhán McSweeney als Witzender |
 | Owain Rhys Davies als Delivery Frog (voice) |
 | Edward Petherbridge als Gentleman Fish (voice) |
| Richard Syms als Board Member |
 | Neil Edmond als Footman |
 | Carol Been als Dancer |
| Ross Carpenter als Dancer |
| Melissa Collier als Dancer |
| Heather Craig als Dancer |
| Janine Craig als Dancer |
 | Leigh Daniels als Dancer |
| Jules Davison als Dancer |
| Matt Dempsey als Dancer |
| Nikki Dunsford als Dancer |
 | Stephanie Elstob als Dancer |
 | Steve Fortune als Dancer |
 | Jane Fowler als Dancer |
 | Adam Galbraith als Dancer |
| Chris Grierson als Dancer |
| Dale Mercer als Dancer |
| William Mowat als Dancer |
| Cris Penfold als Dancer |
| Kraig Thornber als Dancer |
| Carl Walker als Dancer |
| Claire Winsper als Dancer |
 | Isaac Andrews als Second Mate Tom (uncredited) |
| Alexander Bracq als Witzender / Vendor (uncredited) |
| Adam Burton als Goat (uncredited) |
 | Frances de la Tour als Aunt Imogene (uncredited) |
 | Ross Green als Unicorn (uncredited) |
 | Kyle Hebert als Young Bayard (voice) (uncredited) |
 | Matt Hookings als The Hour (uncredited) |
| Bomber Hurley-Smith als Royal Guard (uncredited) |
 | Martyn Mayger als Gentleman (uncredited) |
 | Steve Saunders als Brilliam Hinkle (uncredited) |
| Mike Simmrin als Fisherman (uncredited) |
 | Johanna Smitz als Village Girl (uncredited) |
 | Bill Thomas als Driver |
| James Bobin | Director |
| Linda Woolverton | Screenplay |
| Jonny Franklin | Electrician |
| Danny Elfman | Original Music Composer |
| Tim Burton | Producer |
| Joe Roth | Producer |
| Jennifer Todd | Producer |
| Suzanne Todd | Producer |
| Stuart Dryburgh | Director of Photography |
| Andrew Weisblum | Editor |
| Lucy Bevan | Casting |
| John Papsidera | Casting |
| Alex Cameron | Art Direction |
| Nick Gottschalk | Art Direction |
| Hannah Moseley | Art Direction |
| Richard Selway | Art Direction |
| Gabriela Dolenská | Art Department Coordinator |
| Denise Ball | Assistant Art Director |
| Simon Elsley | Assistant Art Director |
| Gary Jopling | Assistant Art Director |
| Nicky Ackland-Snow | Construction Coordinator |
| Dan Hennah | Production Design |
| Anna Lynch-Robinson | Set Decoration |
| Ra Vincent | Set Decoration |
| John Berger | Set Designer |
| Jann K. Engel | Set Designer |
| Scott Herbertson | Set Designer |
| Jeff Markwith | Set Designer |
| Todd Cherniawsky | Supervising Art Director |
| Niall Moroney | Supervising Art Director |
| Max Tyrie | Animation Supervisor |
| Chris Buckley | Animation Supervisor |
| Craig McPherson | Animation Supervisor |
| Celebrity Booker | Casting Associate |
| Ruth Key | Casting Associate |
| Francesca Jaynes | Choreographer |
| Anna Worley | Script Supervisor |
| Lora E. Revitt | Assistant Costume Designer |
| Donna O'Neal | Costume Supervisor |
| Zoe Cranley | CG Supervisor |
| Shaun Cobley | Camera Operator |
| Pete Cavaciuti | Steadicam Operator |
| Peter Mountain | Still Photographer |
| Susie Allnutt | Additional Photography |
| Tom Lea | Gaffer |
| Harry Wiggins | Gaffer |
| Ian Franklin | Rigging Gaffer |
| Ryan Taggart | First Assistant Camera |
| Tobias Eedy | First Assistant Camera |
| Gabriel Hyman | First Assistant Camera |
| Bill Abbott | Music Editor |
| Lisa Jaime | Music Editor |
| Michael Semanick | Sound Re-Recording Mixer |
| Al Nelson | Supervising Sound Editor |
| Gloria Pasqua Casny | Hairstylist |
| Richard Muller | Hairstylist |
| Donald McInnes | Hairstylist |
| Paula Price | Hairstylist |
| Peter Swords King | Hair Designer |
| Joceline Andrews | Makeup Artist |
| Tamsin Dorling | Makeup Artist |
| Tina Pritchard | Makeup Artist |
| Joel Harlow | Makeup Artist |
| Khanh Trance | Wigmaker |
| Neil Corbould | Special Effects Supervisor |
| Craig Andujar | Visual Effects Coordinator |
| Melyssa Forget Turcotte | Visual Effects Coordinator |
| Megan Galbraith | Visual Effects Coordinator |
| Bridget Swerecki | Visual Effects Coordinator |
| Lei Zhang | Visual Effects Coordinator |
| Patrick Lermitte | Visual Effects Coordinator |
| Gian Ganziano | Visual Effects Editor |
| Derrick Mitchell | Visual Effects Editor |
| Andrew Poole | Visual Effects Editor |
| Xinyi Puah | Visual Effects Editor |
| Elaine C. Andrianos | Visual Effects Editor |
| Mike Chambers | Visual Effects Producer |
| Pinto Sasikumar | Visual Effects Producer |
| Eric Scott | Visual Effects Producer |
| Tamara Watts Kent | Visual Effects Producer |
| Vera Zivny | Visual Effects Producer |
| Ken Ralston | Visual Effects Supervisor |
| Jay Redd | Visual Effects Supervisor |
| Jesper Kjölsrud | Visual Effects Supervisor |
| Andrew Lockley | Visual Effects Supervisor |
| Ollie Rankin | Visual Effects Supervisor |
| Elizabeth Hitt | Digital Intermediate |
| Andy Kaplan | Digital Intermediate |
| Joe Ken | Digital Intermediate |
| Andrew Walton | First Assistant Editor |
| Colleen Atwood | Costume Design |
| Lewis Carroll | Novel |
| Ren Klyce | Sound Designer |
| Terry Woods | Property Master |
| Shaun O'Dell | Second Unit Director of Photography |
| John Marzano | Aerial Director of Photography |
| Richard Roles | Aerial Camera |
| Gwendolyn Yates Whittle | ADR Supervisor |
| Shelley Roden | Foley Artist |
| John Roesch | Foley Artist |
| Chris Navarro | ADR Mixer |
| Darren Sunny Warkentin | ADR Editor |
| Erin Oakley | ADR Supervisor |
| Dustin Cawood | Foley Editor |
| Scott Curtis | Foley Mixer |
| Peter Gleaves | ADR Mixer |
| Ryan Young | ADR Recordist |
| David Parker | Sound Re-Recording Mixer |
| Steve Hancock | Boom Operator |
| John Midgley | Production Sound Mixer |
| Benjamin A. Burtt | Sound Effects Editor |
| Scott Guitteau | Sound Effects Editor |
| John G. Scotti | Executive Producer |
| Jeremy Johns | Co-Producer |
| Jeremy Johns | Unit Production Manager |
| John G. Scotti | Unit Production Manager |
| David Cain | Production Supervisor |
| Shaun O'Dell | Second Unit Director |
| Daniel Rogers | Health and Safety |
| Grant McCord | Costume Assistant |
| Carolina Jiménez | Layout |
| Richard Goodwin | First Assistant Director |
| Flora Moody | Makeup & Hair |
