 | Will Ferrell als Megamind (voice) |
 | Tina Fey als Roxanne Ritchi (voice) |
 | Jonah Hill als Hal Stewart / Tighten (voice) |
 | Brad Pitt als Metro Man (voice) |
 | David Cross als Minion (voice) |
 | Justin Theroux als Megaminds's Father (voice) |
 | Ben Stiller als Bernard (voice) |
 | Jessica Schulte als Megamind's Mother (voice) |
 | Tom McGrath als Lord Scott / Prison Guard (voice) |
 | J.K. Simmons als Warden (voice) |
| Emily Nordwind als Lady Scott (voice) |
 | Quinn Dempsey Stiller als Schoolchild (voice) |
 | Ella Stiller als Schoolchild (voice) |
| Brian Hopkins als Prisoner (voice) |
 | Christopher Knights als Prison Guard (voice) |
 | Mike Mitchell als Father in Crowd (voice) |
 | Jack Blessing als Newscaster (voice) |
| Jasper Johannes Andrews als Crying Baby (voice) |
 | Stephen Kearin als Mayor (voice) |
| Tom McGrath | Director |
| Lara Breay | Producer |
| Denise Nolan Cascino | Producer |
| Stuart Cornfeld | Executive Producer |
| Ben Stiller | Executive Producer |
| Lorne Balfe | Original Music Composer |
| Hans Zimmer | Original Music Composer |
| Andy Schuhler | Storyboard |
| Simon Rodgers | Visual Development |
| Shane Prigmore | Storyboard |
| Kevin Kaska | Orchestrator |
| David James | Production Design |
| Derek Drymon | Thanks |
| Cameron Hood | Thanks |
| Kyle Jefferson | Thanks |
| Mike Mitchell | Thanks |
| Guillermo Navarro | Thanks |
| Debbie L. O'Keeffe | Thanks |
| Gary Trousdale | Thanks |
| Conrad Vernon | Thanks |
| Guillermo del Toro | Creative Consultant |
| Holly Edwards | Associate Producer |
| Justin Theroux | Creative Consultant |
| Michael Andrews | Editor |
| Leslee Feldman | Casting |
| Timothy Lamb | Art Direction |
| Kira Shea Smithson | Administration |
| Chris Bancroft | Animation |
| Martin P. Hopkins | Animation |
| Morgan R. Kelly | Animation |
| Rani Naamani | Animation |
| Ross Burgess | Animation |
| Nazia Khan | Actor's Assistant |
| Marc Bonilla | Additional Music |
| Michael A. Levine | Additional Music |
| Gavin Greenaway | Conductor |
| Ariga Parseghian | Finance |
| Vicki Hunter | Finance |
| Terri Anderson | Finance |
| John T. Cucci | Foley |
| Amanda Johnstone-Batt | Lighting Artist |
| Tom Boyd | Musician |
| Andrew Crowley | Musician |
| Jonathan Evans-Jones | Musician |
| Paul Kegg | Musician |
| Roger Linley | Musician |
| Steve Mair | Musician |
| Michael C. Mason | Musician |
| Dan Newell | Musician |
| Steve Schaeffer | Musician |
| Christine Nguyen | Production Coordinator |
| Bonnie Lemon | Executive In Charge Of Production |
| Erik Pope | Script Supervisor |
| Ariandy Chandra | Title Designer |
| Scott B. Peterson | Visual Effects |
| Doug Pierce | Set Designer |
| Ken Ball | CG Supervisor |
| Annmarie Koenig | CG Supervisor |
| Robert Lurye | CG Supervisor |
| Michael McNeill | CG Supervisor |
| Fatima Robinson | Choreographer |
| Kathy Nelson | Executive Music Producer |
| Mona Shokrai | Legal Services |
| Alissa Rowinsky Wright | Legal Services |
| John Hanashiro | Post Production Supervisor |
| Andrew Birch | Post-Production Manager |
| Gregg Carrier | Software Engineer |
| Patrick Kelly | Software Engineer |
| Margaret A. Decker | Software Engineer |
| Dave Burgess | Supervising Animator |
| Anthony Hodgson | Supervising Animator |
| Sean Mahoney | Supervising Animator |
| Jason Spencer-Galsworthy | Supervising Animator |
| David Torres | Supervising Animator |
| Corban Gossett | Supervising Technical Director |
| Greg Gibson | Systems Administrators & Support |
| Rain Angeles | Systems Administrators & Support |
| Shawn Bohonos | Systems Administrators & Support |
| Dave Dinsmore | Systems Administrators & Support |
| Dj Downey | Systems Administrators & Support |
| Alireza Estakhrian | Systems Administrators & Support |
| Bart Feliciano | Systems Administrators & Support |
| Othieno Okong'o | Systems Administrators & Support |
| John Finklea | Temp Music Editor |
| David Hail | Unit Publicist |
| Liska Ostojic | Script Coordinator |
| John Dorst | Assistant Editor |
| Robert W. Hedland | Assistant Editor |
| Daniel Ortiz | Assistant Editor |
| William M. Steinberg | Assistant Editor |
| Lynn Hobson | Associate Editor |
| Christopher Knights | Associate Editor |
| Michelle Mendenhall | Associate Editor |
| Madison Sellers | Editorial Production Assistant |
| Sucheta Bhatawadekar | Lighting Artist |
| Clint Colver | Lighting Artist |
| Mark A. Decker | Lighting Artist |
| Antoine Deschamps | Lighting Artist |
| Kirsten Drummond | Lighting Artist |
| Julien Forest | Lighting Artist |
| Navjit Singh Gill | Lighting Artist |
| Dorien Gunnels | Lighting Artist |
| Glen Gustafson | Lighting Artist |
| George Ho | Lighting Artist |
| Noel Hocquet | Lighting Artist |
| Gregory Jennings | Lighting Artist |
| Kurt Kaminski | Lighting Artist |
| Oth Khotsimeuang | Lighting Artist |
| Jennifer Leigh King | Lighting Artist |
| Amber Stewart Lunderville | Lighting Artist |
| Pietro Materossi | Lighting Artist |
| Cristian Moras | Lighting Artist |
| Hannah Sherman | Lighting Artist |
| Prapanch Swamy | Lighting Artist |
| Ka Yaw Tan | Lighting Artist |
| Ryan Michael Todd | Lighting Artist |
| Lisa M. Tse | Lighting Artist |
| Benjamin Venancie | Lighting Artist |
| Lori Williams | Lighting Artist |
| Hanwei Wu | Lighting Artist |
| Emily Yi | Lighting Artist |
| Doug Yoshida | Lighting Artist |
| Alfred Young | Lighting Artist |
| Matthieu Grospiron | Lighting Artist |
| Yuko Okumura | Lighting Artist |
| Jack Lilburn | Lighting Coordinator |
| William E. Arias | Master Lighting Artist |
| Max Bruce | Master Lighting Artist |
| Sebastien Chort | Master Lighting Artist |
| Kevin Edwards | Master Lighting Artist |
| Amy Rae Jones | Master Lighting Artist |
| David C. Lawson | Master Lighting Artist |
| Jimmy Maidens | Master Lighting Artist |
| Marc Miller | Master Lighting Artist |
| Tony Mitzelfelt | Master Lighting Artist |
| Ronman Yiu Yan Ng | Master Lighting Artist |
| Eli Rod | Master Lighting Artist |
| Milton E. Rodriguez-Rios | Master Lighting Artist |
| Geri Smith | Master Lighting Artist |
| Jung Jin Song | Master Lighting Artist |
| Jessi Stumpfel | Master Lighting Artist |
| Gina Warr | Master Lighting Artist |
| Gabriel White | Master Lighting Artist |
| Matt Robertson | Administration |
| Brittany Cope | Casting Assistant |
| Mollie Gamo | Casting Assistant |
| Christi Soper Hilt | Casting Associate |
| Darci Zalvin | Executive In Charge Of Production |
| Betty Tom | Production Accountant |
| Lauren Blackshear | Production Coordinator |
| Alyson Blume | Production Coordinator |
| Matthew C. Campbell | Production Coordinator |
| Tim Kwan | Production Coordinator |
| Shane Mulholland | Production Coordinator |
| Rachel Slansky | Production Coordinator |
| Yimi Tong | Production Coordinator |
| Andre de Oliviera Araujo | Production Manager |
| Maude Lewis | Production Manager |
| Kate Spencer | Production Manager |
| Jannette Eng | Production Supervisor |
| Danielle Helsaple | Production Supervisor |
| David Isetta | Production Supervisor |
| Diana K. Lee | Production Supervisor |
| Camille Leganza | Production Supervisor |
| Kelly Matthews | Production Supervisor |
| Robyn Mesher | Production Supervisor |
| Trinity Murphy | Production Supervisor |
| Meredith Narrowe | Production Supervisor |
| Malia P. Russell | Production Supervisor |
| Steven Schweickart | Production Supervisor |
| Ryan Genji Thomas | Production Supervisor |
| Jessie Carbonaro | Production Supervisor |
| Roy Latham | ADR & Dubbing |
| Carlos Sotolongo | ADR & Dubbing |
| R.J. Kizer | ADR Editor |
| Andy Sisul | First Assistant Sound Editor |
| James Ashwill | Foley |
| Dan O'Connell | Foley |
| Ramiro Belgardt | Music Editor |
| Peter Oso Snell | Music Editor |
| Chris Clad | Musician |
| George Doering | Musician |
| Jake Walker | Musician |
| Rick Giovinazzo | Orchestrator |
| Carl Rydlund | Orchestrator |
| Slamm Andrews | Scoring Mixer |
| Daniel Fresco | Scoring Mixer |
| Daniel Kresco | Scoring Mixer |
| P.K. Hooker | Sound Effects Editor |
| John Marquis | Sound Effects Editor |
| Tom Lalley | Sound Engineer |
| Ryan Cole | Sound Recordist |
| Tighe Sheldon | Sound Recordist |
| Anna Behlmer | Sound Re-Recording Mixer |
| Andy Nelson | Sound Re-Recording Mixer |
| Susan Dudeck | Supervising ADR Editor |
| Erik Aadahl | Supervising Sound Editor |
| Ethan van der Ryn | Supervising Sound Editor |
| Mike Beaulieu | Animation |
| Julien Bocabeille | Animation |
| Ludovic Bouancheau | Animation |
| Bailey Brent | Animation |
| Nelson Brown | Animation |
| Laurent Caneiro | Animation |
| Christopher Lee Capel | Animation |
| Guillermo Careaga | Animation |
| Paul Chung | Animation |
| Katrina Conwright | Animation |
| Melanie Cordan | Animation |
| Michelle Cowart | Animation |
| Cameron Fielding | Animation |
| Alexander Fleisig | Animation |
| Ken Fountain | Animation |
| W. Jacob Gardner | Animation |
| Maciek Gliwa | Animation |
| Ryan Gong | Animation |
| Tomoyuki Harashima | Animation |
| Mariko Hoshi | Animation |
| Jeffrey Joe | Animation |
| Scott Lafleur | Animation |
| Peer Lemmers | Animation |
| Tommie Löfqvist | Animation |
| Stephen Melagrano | Animation |
| Irene Parkins | Animation |
| Rebecca Perez | Animation |
| Tyler Phillips | Animation |
| Ron Pucherelli | Animation |
| Luke Randall | Animation |
| Mark Roennigke | Animation |
| Cory Rogers | Animation |
| Ben Rush | Animation |
| Kevan Shorey | Animation |
| David Spivack | Animation |
| Dane Stogner | Animation |
| Philip To | Animation |
| Nara Youn | Animation |
| Nicasio Nakamine | Animation Production Assistant |
| Jason Ryan | Animation Supervisor |
| Andy Bialk | Character Designer |
| Devin Crane | Character Designer |
| Sylvain Deboissy | Character Designer |
| Timothy Lamb | Character Designer |
| Chris Reccardi | Character Designer |
| Tony Siruno | Character Designer |
| Peter Farson | Creature Technical Director |
| Cara Malek | Creature Technical Director |
| Cliff B. Mitchell | Creature Technical Director |
| Stephan Osterburg | Creature Technical Director |
| Sven Pohle | Creature Technical Director |
| Sebastien Potet | Creature Technical Director |
| Kendal Sager | Creature Technical Director |
| Nico Sanghrajka | Creature Technical Director |
| Paul Timpson | Creature Technical Director |
| Priscilla Chiu Yee Tsang | Creature Technical Director |
| Dick Walsh | Creature Technical Director |
| Jeff Wang | Creature Technical Director |
| Guido Zimmermann | Creature Technical Director |
| Drago Avdalovic | Creature Technical Director |
| Adrian Tsang | Creature Technical Director |
| Soongu Kwon | Modeling |
| Steve McGrath | Modeling |
| Paul Schoeni | Modeling |
| Jung Jin Kang | Modeling |
| Jeff Wagner | Modeling |
| John Allwine | VFX Artist |
| Benjamin Andersen | VFX Artist |
| Shinsaku Arima | VFX Artist |
| Greg Beckman | VFX Artist |
| Steven Blakey | VFX Artist |
| Julie Anne Brame | VFX Artist |
| Markus Burki | VFX Artist |
| Robert Chen | VFX Artist |
| Wes Chilton | VFX Artist |
| Tyson Erze | VFX Artist |
| Landon Gray | VFX Artist |
| Laurent Kermel | VFX Artist |
| Robert Kopinsky | VFX Artist |
| Jaemin Lee | VFX Artist |
| Olive Lin | VFX Artist |
| Yancy Lindquist | VFX Artist |
| Gustav Melich | VFX Artist |
| August Meredith | VFX Artist |
| William Opdyke | VFX Artist |
| Alex Patanjo | VFX Artist |
| John Patton | VFX Artist |
| Stephanie Siebert | VFX Artist |
| Osamu Takehiro | VFX Artist |
| Stuart Tett | VFX Artist |
| Katie Van Maanen | VFX Artist |
| Zubin Wadia | VFX Artist |
| Jason Waltman | VFX Artist |
| Philippe Denis | VFX Supervisor |
| Richard Daskas | Visual Development |
| Goro Fujita | Visual Development |
| Alex Hagelis | Visual Development |
| Kory Heinzen | Visual Development |
| Chin Ko | Visual Development |
| Travis Koller | Visual Development |
| Bryan Gregg LaShelle | Visual Development |
| Peter Maynez | Visual Development |
| Sam Michlap | Visual Development |
| Sunil Pant | Visual Development |
| Jason William Scheier | Visual Development |
| Stan Seo | Visual Development |
| James Wood Wilson | Visual Development |
| Raymond Zibach | Visual Development |
| Shaun Graham | Visual Effects |
| Fangwei Lee | Visual Effects |
| Kyle Maxwell | Visual Effects |
| Zeki Melek | Visual Effects |
| Nikita Pavlov | Visual Effects |
| Jason Rickwald | Visual Effects |
| Matt Titus | Visual Effects |
| Reny Preussker | Visual Effects Coordinator |
| Mark Donald | Supervising Animator |
| David G. Derrick Jr. | Story Artist |
| Mackenzie Thompson | Software Engineer |
| Alan Schoolcraft | Writer |
| Brent Simons | Writer |
