 | Jim Carrey als Walter Sparrow / Fingerling |
 | Virginia Madsen als Agatha Sparrow / Fabrizia |
 | Logan Lerman als Robin Sparrow |
 | Danny Huston als Isaac French / Dr. Miles Phoenix |
 | Lynn Collins als Suicide Blonde / Mrs. Dobkins / Young Fingerling's Mother |
 | Rhona Mitra als Laura Tollins |
 | Mark Pellegrino als Kyle Finch |
 | Ed Lauter als Father Sebastian |
 | David Stifel als Hotel Clerk |
 | Corey Stoll als Sergeant Burns |
 | Bud Cort als Dr. Sirius Leary |
 | Michelle Arthur als Sybil |
 | Paul Butcher als Young Fingerling / Young Walter |
 | Troy Kotsur als Barnaby |
 | Patricia Belcher als Dr. Alice Mortimer |
 | Shannon Gayle als Lucinda |
 | Bob Zmuda als Desk Clerk |
 | Lesli Margherita als Attractive Coed |
 | Tara Karsian als Box Company Clerk |
 | Walter Soo Hoo als Chinese Restaurant Owner |
| Joel Schumacher | Director |
| Daniel B. Clancy | Set Decoration |
| Tripp Vinson | Producer |
| Matthew Libatique | Director of Photography |
| Andrew Laws | Production Design |
| Mali Finn | Casting |
| Beau Flynn | Producer |
| Mark Stevens | Editor |
| Fernley Phillips | Screenplay |
| Harry Gregson-Williams | Original Music Composer |
| Daniel Orlandi | Costume Design |
| Bill Corso | Makeup Department Head |
| Donald Dowd | Casting Consultant |
| Brooklyn Weaver | Executive Producer |
| David Sandefur | Art Direction |
| Toby Emmerich | Executive Producer |
| Keith Goldberg | Executive Producer |
| Richard Brener | Executive Producer |
| Jon Billington | Art Direction |
| Mike Drake | Executive Producer |
| Linda Fields | Associate Producer |
| Fernley Phillips | Co-Producer |
| Eli Richbourg | Executive Producer |
| Jon H. Epstein | Stunts |
| Bob Brown | Stunts |
| Simone Bargetze | Stunt Double |
