 | Eddie Redmayne als Stephen Hawking |
 | Felicity Jones als Jane Hawking |
 | Charlie Cox als Jonathan Hellyer Jones |
 | Emily Watson als Beryl Wilde |
 | Simon McBurney als Frank Hawking |
 | David Thewlis als Dennis Sciama |
 | Maxine Peake als Elaine Mason |
 | Harry Lloyd als Brian |
 | Tom Prior als Robert Hawking (Age 17) |
 | Sophie Perry als Lucy Hawking (Age 14) |
| Finlay Wright-Stephens als Timothy Hawking (Age 8) |
 | Alice Orr-Ewing als Diana King |
 | Thomas Morrison als Carter |
 | Michael Marcus als Ellis |
 | Gruffudd Glyn als Rees |
 | Paul Longley als Barman - Rowing Club |
| Guy Oliver-Watts als George Wilde |
 | Lucy Chappell als Mary Hawking |
 | Charlotte Hope als Philippa Hawking |
 | Abigail Cruttenden als Isobel Hawking |
| Nicholas Gerard-Martin als Physicist #1 |
| Brett Brown als Physicist #2 |
| Anthony Skrimshire als Physicist #3 |
 | Christian McKay als Roger Penrose |
 | Adam Godley als Senior Doctor - Cambridge Hospital |
 | Nicola Sloane als Bedder |
| Lottie Hamilton als Robert Hawking (New Born) |
 | Enzo Cilenti als Kip Thorne |
| Rufus Taylor als Robert Hawking (Age 2) |
| Delilah Sexton als Lucy Hawking (New Born) |
 | Eileen Davies als Eileen Bond |
 | Simon Chandler als John Taylor |
 | Georg Nikoloff als Khalatnikov |
| Oliver Payne als Robert Hawking (Age 8) |
 | Raffiella Chapman als Lucy Hawking (Age 6) |
| Sam Houston als Timothy Hawking (Baby) |
 | Victoria Emslie als Sarah (Geneva Student) |
 | Frank Lebœuf als Swiss Doctor |
| Will Barton als Technician |
| Lucy Challenger als Female Fan |
| Nicola Victoria Buck als Cockcroft Guest #2 |
| Stuart Benson als Cockcroft Guest #3 |
 | Andrew Bridgmont als Cockcroft Guest #5 |
| Jamie Edwards als Cockcroft Guest #4 |
| Jumaane Brown als Cockcroft Guest #1 |
 | Becky Bush als Undergraduate (uncredited) |
| James Marsh | Director |
| Benoît Delhomme | Director of Photography |
| Eric Fellner | Producer |
| Lisa Bruce | Producer |
| Anthony McCarten | Producer |
| Jinx Godfrey | Editor |
| John Paul Kelly | Production Design |
| Clare Nia Richards | Set Decoration |
| Stephen Noble | Costume Design |
| Tim Bevan | Producer |
| Nina Gold | Casting |
| Agnes Legere | Hairstylist |
| Kira Kemble | Assistant Art Director |
| Adam Scrivener | Sound Re-Recording Mixer |
| Ian Tapp | Sound Re-Recording Mixer |
| Glenn Freemantle | Supervising Sound Editor |
| Glenn Marks | Stunt Coordinator |
| Pat Sweeney | Gaffer |
| Natasha Cousins | Costume Supervisor |
| Mark Keady | First Assistant Editor |
| Allan Jenkins | Music Editor |
| Sylvia Parker | Script Supervisor |
| Rebecca Pearson | Location Manager |
| David Campbell-Bell | Location Manager |
| Jill McCullough | Dialect Coach |
| Rachel Kennedy | Unit Publicist |
| Jane Hawking | Book |
| Danny Freemantle | Sound Designer |
| Gerry Vasbenter | Steadicam Operator |
| Lesley Smith | Key Makeup Artist |
| Liam McGill | Rigging Gaffer |
| Liam Daniel | Still Photographer |
| Paul Wrightson | ADR Editor |
| Sarah Bridge | Music Supervisor |
| Claire Freeman | Music Supervisor |
| John Warhurst | Music Editor |
| Anthony Weeden | Orchestrator |
| Jóhann Jóhannsson | Orchestrator |
| Anthony McCarten | Screenplay |
| Amelia Granger | Executive Producer |
| Liza Chasin | Executive Producer |
| David Kosse | Executive Producer |
| Richard Hewitt | Co-Producer |
| Jan Sewell | Prosthetic Designer |
| Jan Sewell | Hair Designer |
| Jan Sewell | Makeup Designer |
| Jóhann Jóhannsson | Music |
| Lucas Webb | Associate Producer |
| Alison Banks | Unit Production Manager |
| Deborah Saban | First Assistant Director |
| Colin Nicolson | Production Sound Mixer |
| Craig Barwick | Production Accountant |
| David Hindle | Supervising Art Director |
| Mark Milsome | Camera Operator |
| Alice Sutton | Art Department Assistant |
| Mark Keady | Associate Editor |
| Agnes Legere | Makeup Artist |
| Mark Holt | Special Effects Supervisor |
| Lauren Evans | Casting Associate |
| Theo Park | Casting Assistant |
| Robert Sterne | Casting Assistant |
| Gillian Dodders | ADR Editor |
| Nicholas Freemantle | Assistant Sound Editor |
| Glen Gathard | Foley Editor |
| Anita Burger | Makeup Artist |
| Alex Rouse | Wigmaker |
| Mat Campbell | Greensman |
| Bruce Gordon | Sculptor |
| Dean Hawley | Painter |
| Tim Lanning | Greensman |
| Ben Barker | Sound Designer |
| Dillon Bennett | Sound Effects Editor |
| Colin Gregory | Boom Operator |
| Eilam Hoffman | Sound Effects Editor |
| Derek Trigg | Foley Editor |
| Ines Li | Visual Effects Coordinator |
| Finola O'Brien | Visual Effects Coordinator |
| Noga Alon Stein | Visual Effects Producer |
| Jim Philpott | Key Grip |
| Matt Curtis | Title Designer |
| Carrie-Ann Banner | Production Coordinator |
| Kristyan Mallett | Prosthetic Supervisor |
| Gillian Dodders | Dialogue Editor |
| Paul Wrightson | Dialogue Editor |
| Dan Maslen | Storyboard Artist |
| Craig Price | Property Master |
| Kevin Day | Props |
