 | Nicholas Rowe als Sherlock Holmes |
 | Alan Cox als John Watson |
 | Sophie Ward als Elizabeth Hardy |
 | Anthony Higgins als Professor Rathe |
 | Susan Fleetwood als Mrs. Dribb |
 | Roger Ashton-Griffiths als Det. Sgt. Lestrade |
 | Matthew Ryan als Dudley's Friend |
| Earl Rhodes als Dudley |
 | Freddie Jones als Chester Cragwitch |
 | Patrick Newell als Bentley Booster |
 | Nadim Sawalha als Khasek - Lower Nile Tavern Owner |
 | Nigel Stock als Rupert T. Waxflatter |
 | Brian Oulton als Master Snelgrove |
 | Donald Eccles als The Reverend Duncan Nesbitt |
| Matthew Blakstad als Dudley's Friend |
| Jonathan Lacey als Dudley's Friend |
 | Walter Sparrow als Ethan Engel |
 | Roger Brierley als Mr. Holmes |
 | Vivienne Chandler als Mrs. Holmes |
 | Lockwood West als Curio Shop Owner |
 | John Scott Martin als Cemetery Caretaker |
 | George Malpas als School Porter |
 | Willoughby Goddard als School Reverend |
| Michael Cule als Policeman with Lestrade |
 | Ralph Tabakin als Policeman in Shop Window |
 | Nancy Nevinson als Hotel Receptionist |
 | Michael Hordern als Older Watson (voice) |
| Grant Burns als Schoolboy (uncredited) |
| George Lane Cooper als Acolyte (uncredited) |
 | Salo Gardner als Chestnut Seller (uncredited) |
| Lew Hooper als Restaurant Patron (uncredited) |
| Royston Munt als Footman (uncredited) |
| Henry Roberts als School Master (uncredited) |
 | Fred Wood als Patron (Lower Nile Tavern) (uncredited) |
| Arthur Conan Doyle | Characters |
| Mark Johnson | Producer |
| Stephen Goldblatt | Director of Photography |
| Stu Linder | Editor |
| Barry Levinson | Director |
| Chris Columbus | Screenplay |
| Kathleen Kennedy | Executive Producer |
| Steven Spielberg | Executive Producer |
| Frank Marshall | Executive Producer |
| Bruce Broughton | Original Music Composer |
| Henry Winkler | Producer |
| Reg Bream | Draughtsman |
| Norman Reynolds | Production Design |
| Harry Benn | Associate Producer |
| Roger Birnbaum | Producer |
| Irene Lamb | Casting |
| Charles Bishop | Art Direction |
| Fred Hole | Art Direction |
| Michael Ford | Set Decoration |
| Raymond Hughes | Costume Design |
| Nick Dudman | Makeup Artist |
| Peter Robb-King | Makeup Supervisor |
| Jane Royle | Makeup Artist |
| Andrew Grieve | Second Unit Director |
| Michael Murray | First Assistant Director |
| Ian Hickinbotham | Second Assistant Director |
| Peter Heslop | Third Assistant Director |
| Gavin Bocquet | Assistant Art Director |
| Paul Cheesman | Dressing Prop |
| Peter Childs | Draughtsman |
| George Djurkovic | Assistant Art Director |
| Michael Ploog | Art Designer |
| David Allen | Visual Effects Supervisor |
| Donna K. Baker | Rotoscoping Artist |
| Gordon Baker | Animation |
| Barbara Brennan | Animation |
| Dave Carson | Art Direction |
| Sean M. Casey | Visual Effects |
| Blair Clark | Visual Effects |
| Don Conway | Animation |
| Robert L. Cook | Animation |
| Robert Cooper | Visual Effects |
| Jay Davis | Visual Effects |
| David DiFrancesco | Animation |
| Craig Good | Animation |
| Ellen Lichtwardt Goodchild | Animation Supervisor |
| John Lasseter | Animation |
| Tony Laudati | Visual Effects |
| Marghi McMahon | Visual Effects |
| Jack Mongovan | Animation |
| Dennis Muren | Visual Effects Supervisor |
| Eben Ostby | Animation |
| William Reeves | Animation |
| David Salesin | Animation |
| Bruce Walters | Animation Supervisor |
| Tony Hudson | Visual Effects |
| Jay Riddle | Visual Effects Camera |
