 | Jack Black als R.L. Stine |
 | Dylan Minnette als Zach Cooper |
 | Odeya Rush als Hannah Fairchild |
 | Amy Ryan als Gale Cooper |
 | Ryan Lee als Champ |
 | Jillian Bell als Lorraine Conyers |
 | Halston Sage als Taylor |
 | Ken Marino als Coach Carr |
 | Timothy Simons als Officer Stevens |
 | Amanda Lund als Officer Brooks |
 | Steven Krueger als Davidson |
 | Keith Arthur Bolden als Principal Garrison |
 | Karan Soni als Mr. Rooney |
 | R.L. Stine als Hallway Player |
 | Caleb Emery als Dumb Jock |
 | Gabriela Hernandez als Screaming Girl |
| Nate Andrade als Monster |
| Sheldon Brown als Monster |
| Melissa Brewer als Monster |
| Marshall Choka als Monster |
| Melissa Cowan als Monster |
| John Deifer als Monster |
| Everett Dixon als Monster |
| Brian Gabriel als Monster |
| Kevin Galbraith als Monster |
| Maryann Gorka als Monster |
| Clare Halstead als Monster |
| Devin Hampton als Monster |
| Rory Healy als Monster |
 | Drew Lamkins als Monster |
| Vivian Kyle als Monster |
| Charlie Leach als Monster |
| Katie Lumpkin als Monster |
 | Larry Mainland als Monster |
 | Lucky Mangione als Monster |
| Justin Natic als Monster |
| Josh Phillips als Monster |
| Mickie Pollock als Monster |
| Steve Quinn als Monster |
| Ashleigh Jo Sizemore als Monster |
| Jeff Tenney als Monster |
 | Jennifer Trudrung als Monster |
 | Ashton Lee Woolen als Monster |
| Coleman Youmans als Monster |
 | E. Roger Mitchell als Mayor (uncredited) |
 | Jason Davis als Cyclist (uncredited) |
| Ella Wahlestedt als Anna (uncredited) |
| Rob Letterman | Director |
| Darren Lemke | Screenplay |
| Larry Karaszewski | Story |
| R.L. Stine | Novel |
| Scott Alexander | Story |
| Danny Elfman | Original Music Composer |
| Tania Landau | Executive Producer |
| Patrick M. Sullivan | Art Direction |
| Neal H. Moritz | Producer |
| Dawn Snyder | Art Direction |
| Javier Aguirresarobe | Director of Photography |
| Sean Haworth | Production Design |
| Bill Bannerman | Executive Producer |
| Nicole Abellara Hallman | Casting |
| Jeanne McCarthy | Casting |
| Greg Baxter | Co-Producer |
| Deborah Forte | Producer |
| Jim May | Editor |
| Bruce Berman | Executive Producer |
| Andrew White | Art Direction |
| Greg Basser | Executive Producer |
| Frank Galline | Set Decoration |
| Judianna Makovsky | Costume Design |
| Ben Waisbren | Executive Producer |
| Patrick McArdle | First Assistant "B" Camera |
| John Marquis | Sound Designer |
| Ashley Marie Parker | Costumer |
| Chris Lumpkin | Key Rigging Grip |
| John Schisler | Transportation Co-Captain |
| Bill Abbott | Music Editor |
| Mariana Sánchez de Antuñano | First Assistant "A" Camera |
| Nick Scarano | Costume Supervisor |
| Valerie Rudolph | Costumer |
| Fionagh Cush | Makeup Effects |
| Jeff Curtis | Dolly Grip |
| Dempsey Tillman | Video Assist Operator |
| Steven Ramirez | Visual Effects Editor |
| Carlos Huante | Creature Design |
| Douglas Womack | Construction Coordinator |
| Ross Davis | Second Assistant "B" Camera |
| Roz Music | Makeup Artist |
| Eric Rylander | Special Effects Supervisor |
| Steve Cainas | Production Coordinator |
| Anna P. McCarthy | Casting Assistant |
| Joshua Kirchmer | Assistant Editor |
| Nancy Nugent | Supervising Dialogue Editor |
| Robin Harlan | Foley Artist |
| Denise Okimoto | Music Editor |
| Haley Sweet | Production Supervisor |
| Phyllis Temple | Key Makeup Artist |
| John Frazier | Special Effects Coordinator |
| Marco Rubeo | Set Designer |
| Thomas Minton | Set Designer |
| Polly McKinnon | Supervising ADR Editor |
| Howard London | ADR Mixer |
| Terry Wilson | Music Editor |
| Valeria Migliassi Collins | Script Supervisor |
| Jacques Jouffret | Steadicam Operator |
| Tim Guffin | Second Assistant "A" Camera |
| Kerry Rawlins | Key Grip |
| Jonathan Klein | Foley Supervisor |
| Bill Bannerman | Unit Production Manager |
| Brown Cooper | "B" Camera Operator |
| Sarah Downer | Costumer |
| Iliana Sanchez | Costumer |
| C. Ashley Sudge | Dolly Grip |
| Randy Singer | Foley Mixer |
| Roz Music | Hairstylist |
| Steve Zigler | Rigging Gaffer |
| Justin Fields | Creature Design |
| John Marquis | Supervising Sound Editor |
| Stephen A. Pope | Stunt Coordinator |
| Leighton Bowers | Assistant Costume Designer |
| Neville Page | Creature Design |
| Ethan van der Ryn | Supervising Sound Editor |
| Adruitha Lee | Hair Department Head |
| Mary H. Ellis | Sound Mixer |
| James Peterson | Boom Operator |
| Richard Blake Wester | Leadman |
| Bob Kellough | Sound Effects Editor |
| Nancy Nugent | Supervising ADR Editor |
| Jesse Rosenman | Assistant Sound Editor |
| Sarah Monat | Foley Artist |
| Dawn Massaro | Second Assistant Director |
| Michelle Liu | Key Costumer |
| Elizabeth Robinson | Key Hair Stylist |
| Tracy Kilpatrick | Local Casting |
| Melissa Mason | Costumer |
| Stephen Crowley | Gaffer |
| Mackie Roberts | Best Boy Grip |
| Dylan Jury | Casting Associate |
| Jonathan Smith | Transportation Co-Captain |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Jacques Jouffret | "A" Camera Operator |
| Michael J. Davis | Best Boy Electric |
| Tamara Bally | Production Controller |
| Debra L. Tennant | Additional Editing |
| Erik Nordby | Visual Effects Supervisor |
| Daniel Woods | Production Secretary |
| Stacie McKinnon | Art Department Coordinator |
| Claire Raskind | Unit Publicist |
| Hopper Stone | Still Photographer |
| Jason W. Jennings | Sound Designer |
| Eric J. Bates | Property Master |
| Fionagh Cush | Makeup Department Head |
| Maida N. Morgan | Location Manager |
| Vincent Bates | Set Designer |
| Logan Breit | Visual Effects Editor |
| Beau Borders | Sound Re-Recording Mixer |
| Polly McKinnon | Supervising Dialogue Editor |
| Doug Wright | Transportation Captain |
| Brian Price | Executive Producer's Assistant |
| Riley Flanagan | Set Production Assistant |
| Jennifer Badger | Stunts |
| G. A. Aguilar | Second Unit Director |
| Danya Bateman | Stunt Double |
| Meredith Richardson | Stunt Double |
