 | Xolo Mariduena als Jaime Reyes / Blue Beetle |
 | Bruna Marquezine als Jenny Kord |
 | Susan Sarandon als Victoria Kord |
 | Raoul Max Trujillo als Carapax |
 | Belissa Escobedo als Milagros Reyes |
 | Damián Alcázar als Alberto Reyes |
 | Elpidia Carrillo als Rocío Reyes |
 | George Lopez als Rudy Reyes |
 | Adriana Barraza als Nana Reyes |
 | Becky G als Khaji-Da (voice) |
 | Harvey Guillén als Dr. Sanchez |
 | Jorge Jimenez als Tío Chema |
 | Eyra Agüero Joubert als Tía Maru |
 | Gabrielle Ortiz als Tía Letty |
 | Chente Ydrach als Old Man in Airport |
 | Modesto Lacen als General Crane |
| Oshún Ramirez als Nayeli |
 | Brianna Quinn Lewis als Kord Receptionist |
 | Tahj Vaughans als Dude #1 |
| Dante Gonzalez-Abreu als Dude #2 |
| Jon Z als Dude #3 |
 | Carlos Ponce als Bentley Owner |
 | Franco Castan als Security Tech #1 |
 | Perris Drew als Security Tech #2 |
 | Felipe Esparza als Security Tech #3 |
| Walter J. Buck als Security Tech #4 |
 | Jackson Spidell als Black Ops Leader |
 | Esteban Ruiz als Sebastian - Wall Guard #1 |
| Marcus Nelson als Giovanni - Wall Guard #2 |
| Isabella Aparicio als Young Jenny Kord |
| Ayden Rivera als Kid Carapax |
| Xol Gonzalez als Teen Carapax |
 | Yuli Zorrilla als Carapax's Mom |
 | Sergio Valente als Soldier |
| Ángel Manuel Soto | Director |
| John Rickard | Producer |
| Pawel Pogorzelski | Director of Photography |
| Craig Alpert | Editor |
| Jon Billington | Production Design |
| Walter Hamada | Executive Producer |
| Gareth Dunnet-Alcocer | Writer |
| Chelsea Ellis Bloch | Casting |
| Marisol Roncali | Casting |
| Ricky Aguirre | Art Direction |
| Artie Contreras | Art Direction |
| Nathan Krochmal | Art Direction |
| Arielle Ness-Cohn | Art Direction |
| Jay Pelissier | Supervising Art Director |
| Jennifer M. Gentile | Set Decoration |
| Anna Elisa Mackowiak | Production Supervisor |
| K.C. Hodenfield | First Assistant Director |
| Ben White | Second Assistant Director |
| Jody Blose | Script Supervisor |
| Mark Hawker | Special Effects Supervisor |
| Kevin Cerchiai | Boom Operator |
| Bobby Krlic | Original Music Composer |
| Zev Foreman | Producer |
| Galen Vaisman | Executive Producer |
| Garrett Grant | Executive Producer |
| Kelvin McIlwain | Visual Effects Supervisor |
| J.J. Perry | Second Unit Director |
| Season Kent | Music Supervisor |
| Mayes C. Rubeo | Costume Design |
| Eric Townsend | Set Dresser |
| Renae Moneymaker | Stunts |
| Monica Lopez Aleman | Stunts |
| Blanca Rosa Rosario | Stunts |
| Michelle Rose | Stunts |
| Caleb Spillyards | Stunts |
| Jon Valera | Stunt Coordinator |
| William Tang | Stunts |
| Tony Vo | Stunts |
| Jewelianna Ramos-Ortiz | Stunts |
| Justin Ortiz | Stunts |
| Kyle Murillo | Stunts |
| Matthew Austin Murray | Stunts |
| Ross Kohnstam | Stunts |
| Jeremy Marinas | Stunts |
| Bobby Jordan | Stunts |
| Michael D. Jenkins | Stunts |
| Erika Keck | Stunts |
| Rob King | Stunts |
| Erin Haus | Stunts |
| Marian Green | Stunts |
| Jenin Gonzalez | Stunts |
| Daniel Graham | Stunts |
| Miguel-Andres Garcia | Stunts |
| Holly Dowell | Stunts |
| Marché Day | Stunts |
| John Dixon | Stunts |
| Lenny Cruz | Stunts |
| Geo Corvera | Stunts |
| Diego Davila-Rivera | Stunts |
| Michelle Cortés | Stunts |
| Cara Marie Chooljian | Stunts |
| Anis Cheurfa | Stunts |
| Gianni Biasetti Jr. | Stunts |
| Jwaundace Candece | Stunts |
| Alec Back | Stunts |
| Danya Bateman | Stunts |
| Michelle Andrea Adams | Stunts |
| Airon Armstrong | Stunts |
| K.C. Hodenfield | Co-Producer |
| Jacqueline Bell | Key Hair Stylist |
| Brittanie Cruz | Makeup Artist |
| Mollie Ennis | Makeup Artist |
| JT Franchuk | Hairstylist |
| Kimberly Jones | Makeup Department Head |
| Susan Reilly LeHane | Makeup Artist |
| Edward T. Hanley | Costume Supervisor |
| Maegan Robinson | Set Costumer |
| Addy Steigerwalt | Set Costumer |
| Andrew DeCristofaro | Supervising Sound Editor |
| Luis Galdames | Sound Effects Editor |
| Darrin Mann | Foley Mixer |
| Christopher Moriana | Foley Artist |
| Chris Terhune | Sound Designer |
| Darren Sunny Warkentin | Supervising Sound Editor |
| Stephanie L. Allen | Set Decoration Buyer |
| Juan Cervantes | Set Dresser |
| Colton Comans | Set Dresser |
| Chris Cortner | Set Designer |
| Margaret Ditre | Set Designer |
| Rusty Grimes II | Set Dresser |
| George Lee | Set Designer |
| Diem Ngo | Assistant Art Director |
| Yolande Thame | Set Designer |
| Tina Cianfaro Watson | Set Decoration Buyer |
| Arian Nikjeh | Visual Effects Producer |
| Alice S. Kim | Co-Producer |
| Julian Ashby | Art Direction |
| Aaron Kelly | Assistant Art Director |
| Emma Sparer | Set Designer |
| Sara Corral | Graphic Designer |
| Ellen Lampl | Graphic Designer |
| Whit Norris | Production Sound Mixer |
| Jason Oliver | ADR Mixer |
| Tami Treadwell | ADR Mixer |
| Jeffrey Roy | ADR Mixer |
| Alyson Dee Moore | Foley Artist |
| Will Files | Sound Designer |
| David Farmer | Sound Designer |
| Tony Lamberti | Sound Effects Editor |
| Angelo Palazzo | Sound Effects Editor |
| Michael Payne | Sound Effects Editor |
| Lee Gilmore | Supervising Sound Effects Editor |
| Will Files | Sound Re-Recording Mixer |
| Mark Paterson | Sound Re-Recording Mixer |
| Bruce Tanis | Foley Supervisor |
| Kristen McGary | Set Decoration Buyer |
| Jeri Baker | Hair Department Head |
| Robert Wilson | Key Hair Stylist |
| Amanda Bianchi | Key Makeup Artist |
| Bobby Hernandez | Stunts |
| Emely Cartagena | Stunts |
| Maya Santandrea | Stunts |
| Nicole Diane Rios | Stunts |
| Efka Kvaraciejus | Stunts |
| Richard Marrero | Stunts |
| Jaden Ponce | Stunts |
| Jared Losano | Stunts |
| Kade Pittman | Stunts |
| Stephen Grum | Chief Lighting Technician |
| Keith Giffen | Thanks |
| John Rogers | Thanks |
| Cully Hamner | Thanks |
| Paris Cullins | Thanks |
| Will Eisner | Thanks |
| Mike Norton | Thanks |
| Dan Didio | Thanks |
| Joe Gill | Thanks |
| Steve Ditko | Thanks |
| Jack Kirby | Thanks |
| Len Wein | Thanks |
| David Siegel | Thanks |
| Roberto Gómez | Thanks |
| Christopher M. Bauer | Grip |
| Stephen Grum | Gaffer |
| Eduardo Mariota | Camera Operator |
| Natasha I. Nieves | Grip |
| Angel Pastrana | Grip |
| Kristi Lugo | Casting Associate |
| Katrin Arndt | Visual Effects Producer |
| Russell Earl | Visual Effects Supervisor |
| Malcolm Humphreys | Visual Effects Supervisor |
| James Schembri | Visual Effects Producer |
| Oliver Schulz | Visual Effects Supervisor |
| Sarah Swick | Visual Effects Producer |
| Samuel Tremblay | Visual Effects |
| Tini Wider | Visual Effects Producer |
| Chad Wiebe | Visual Effects Supervisor |
| Ryan Wilk | Visual Effects Producer |
| Clement Zveguintzoff | Visual Effects Producer |
| Peter Safran | Producer |
| Jeffrey F. January | Second Unit First Assistant Director |
| Nix Herrera | Special Effects Makeup Artist |
