 | Paul Terry als James Henry Trotter |
 | Miriam Margolyes als Aunt Sponge / Glowworm (voice) |
 | Joanna Lumley als Aunt Spiker |
 | Pete Postlethwaite als The Magic Man |
 | Simon Callow als Grasshopper (voice) |
 | Richard Dreyfuss als Centipede (voice) |
 | Jane Leeves als Ladybug (voice) |
 | Susan Sarandon als Miss Spider (voice) |
 | David Thewlis als Earthworm (voice) |
 | Steven Culp als James' Father |
 | Susan Turner-Cray als James' Mother |
| Cirocco Dunlap als Girl with Telescope |
 | Kathryn Howell als Woman in Bathrobe |
 | Mike Starr als Cop |
| Michael Girardin als Reporter #1 |
| J. Stephen Coyle als Reporter #2 |
| Tony Haney als Reporter #3 |
| Mario Yedidia als Street Kid |
 | Jeff Mosley als Hard Hat Man |
 | Jeff Bennett als Centipede (singing voice) (uncredited) |
| Sally Stevens als Glowworm (singing voice) (uncredited) |
| Henry Selick | Director |
| Jake Eberts | Executive Producer |
| Denise Di Novi | Producer |
| Stan Webb | Editor |
| Steve Bloom | Screenplay |
| Pete Kozachik | Director of Photography |
| Hiro Narita | Director of Photography |
| Jonathan Roberts | Screenplay |
| Roald Dahl | Novel |
| Karey Kirkpatrick | Screenplay |
| Tim Burton | Producer |
| Rich Zim | Animation |
| Anthony Scott | Animation |
| Chuck Duke | Animation |
| Sean Burns | Animation |
| Justin Kohn | Animation |
| Guionne Leroy | Animation |
| Kent Burton | Animation |
| Tom Gibbons | Animation |
| Timothy Hittle | Animation |
| Daniel Mason | Animation |
| Trey Thomas | Animation |
| Jane Hartwell | Animation Manager |
| Tim Myers | Animation |
| Webster Colcord | Animation |
| Mike Belzer | Animation |
| Owen Klatte | Animation |
| Paul Berry | Animation Supervisor |
| Josephine Huang | Animation |
| Tom St. Amand | Animation |
| Jerrold Howard | Animation |
| Christopher Rand | Animation |
| Chris Gilligan | Animation |
| James Stimson | Art Department Manager |
| Stephen A. Buckley | Animation |
| Mike Johnson | Animation |
| Sue Pugh | Animation |
| Paul Jessel | Animation |
| John Bermudes | Compositors |
| Martin Meunier | Other |
| Ross Shuman | Other |
| Lane Smith | Conceptual Design |
| John Hubbard | Casting |
| Ros Hubbard | Casting |
| Henry Selick | Co-Producer |
| Chris Montan | Executive Music Producer |
| Harley Jessup | Production Design |
| Brian Rosen | Co-Producer |
| Robin Gurland | Casting |
| Bill Boes | Art Direction |
| Brian Chavanne | Casting |
| Gary Rydstrom | Sound Re-Recording Mixer |
| Gary Rydstrom | Sound Designer |
| Mike Cachuela | Storyboard Artist |
| Laura Schultz | Animation Coordinator |
| Randy Newman | Songs |
| Randy Newman | Original Music Composer |
| Gary Kachelhoffer | Animation |
| Owen Klatte | Visual Effects |
