 | Andrew Garfield als Peter Parker / Spider-Man |
 | Emma Stone als Gwen Stacy |
 | Jamie Foxx als Max Dillon / Electro |
 | Dane DeHaan als Harry Osborn / Green Goblin |
 | Colm Feore als Donald Menken |
 | Felicity Jones als Felicia Hardy |
 | Paul Giamatti als Aleksei Sytsevich / The Rhino |
 | Sally Field als Aunt May |
 | Embeth Davidtz als Mary Parker |
 | Campbell Scott als Richard Parker |
 | Marton Csokas als Dr. Ashley Kafka |
 | Louis Cancelmi als Man in Black Suit |
 | Max Charles als Young Peter Parker |
 | B.J. Novak als Allistar Smythe |
 | Sarah Gadon als Kari |
 | Michael Massee als Gustav Fiers |
 | Jorge Vega als Jorge |
 | Bill Heck als G-5 Co-Pilot |
 | Teddy Coluca als Gwen's Cabbie |
 | Helen Stern als British Desk Attendant |
 | Aidy Bryant als Statue of Liberty Lady |
 | Cal McCrystal als Principal Conway |
 | Anslem Richardson als Times Square Cop |
 | Mark Doherty als SWAT Team Leader |
 | James Colby als Lead Officer |
 | Kari Coleman als Helen Stacy |
 | Skyler Gisondo als Howard Stacy |
 | Charlie DePew als Philip Stacy |
 | Robert Newman als Police Captain |
 | Adrian Martinez als Bodega Cashier |
 | Thaddeus Phillips als Robber |
 | James McCauley als Air Traffic Controller |
 | Rachael McOwen als Dispatcher |
 | David Shabtai als Dispatcher |
 | Greg Connolly als Osborn Butler |
 | Timothy Adams als Pilot |
 | Tug Coker als Pilot |
 | Jabari Gray als Pilot |
 | Jamie Lynn Concepcion als Jorge's Mother |
 | Pat Kiernan als NY1 News Anchor |
| Jessica Abo als NY1 Reporter |
 | Clem Cheung als Chinese Grandpa |
| Dusan Hyska als Armed Robber |
 | Andrei Runtso als Armed Robber |
| Brennan Taylor als Ravencroft Guard |
 | Slate Holmgren als Ravencroft Guard |
| Drew Beasley als Bully |
| Matthew Tronieri als Bully |
 | Dario Barosso als Bully |
| Salvatore Rossi als Bully |
| Peter KT Tzotchev als Bully |
 | Paul Urcioli als Doctor |
 | David Shih als Doctor |
 | Daniel Gerroll als OsCorp Department Head |
| Brian McElhaney als Times Square Bystander |
 | Jonathan Braylock als Times Square Bystander |
 | Steven Hauck als Corporate Lawyer |
 | J.D. Walsh als Dr. Jallings, Science Investigator |
 | Stan Lee als Graduation Guest |
 | Jessica Shea Alverson als Graduation Parent (uncredited) |
 | Stefanie Barry als Times Square driver (uncredited) |
 | Chris Cooper als Norman Osborn (uncredited) |
 | BJ Davis als NYPD Officer (uncredited) |
 | Julia Davis als NYPD Officer (uncredited) |
 | Frank Deal als Agent Berkley (uncredited) |
 | Odette Warder Henderson als Pedestrian (uncredited) |
 | Denis Leary als Captain Stacy (uncredited) |
 | Lynn Marocola als Times Square Tourist (uncredited) |
 | Josh Elliott Pickel als Bully (uncredited) |
 | Jacob Rodier als Simon Stacy (uncredited) |
 | Martin Sheen als Uncle Ben (uncredited) |
 | Rick Bolander als Pedestrian (uncredited) |
 | Amyrh Harris als Young Peter's Friend (uncredited) |
| Jeff Pinkner | Screenplay |
| Matt Tolmach | Producer |
| Dan Mindel | Director of Photography |
| Ve Neill | Makeup Artist |
| Mark Friedberg | Production Design |
| Pietro Scalia | Editor |
| Marc Webb | Director |
| Roberto Orci | Screenplay |
| James Vanderbilt | Story |
| Avi Arad | Producer |
| Deborah L. Scott | Costume Design |
| Alex Kurtzman | Screenplay |
| Alex Kurtzman | Story |
| Roberto Orci | Story |
| Jeff Pinkner | Story |
| Johnny Marr | Original Music Composer |
| Hans Zimmer | Original Music Composer |
| Kim Jennings | Art Direction |
| Susan Bode Tyson | Set Decoration |
| Noelle King | Set Designer |
| Sarah Monat | Foley |
| Joe Digaetano | Special Effects Coordinator |
| Lisa Lovaas | Costume Supervisor |
| Tim Croshaw | Set Designer |
| Addison Teague | Supervising Sound Editor |
| James Armstrong | Stunt Coordinator |
| Jason Farrar | Location Manager |
| Kathleen Chopin | Casting |
| John Caglione Jr. | Makeup Department Head |
| Douglas Poland | Art Department Coordinator |
| Donna Maloney | Costume Supervisor |
| Nicole Greenbaum | Costume Supervisor |
| Don Lee | Visual Effects Supervisor |
| Hamilton Sterling | Sound Effects Editor |
| Donna Belsky | Studio Teachers |
| Luis Galdames | Sound Effects Editor |
| Kim Lee | Visual Effects Producer |
| James Fanning | Transportation Captain |
| Kira Smith | Boom Operator |
| Ashley Beck | Visual Effects Supervisor |
| Gregory L. McMurry | Visual Effects Supervisor |
| Andy Armstrong | Stunt Coordinator |
| Nevin Seus | Music Editor |
| Tim Zydel | Greensman |
| Lee Gilmore | Sound Effects Editor |
| Robin Harlan | Foley |
| Eric A. Norris | Sound Designer |
| Pharrell Williams | Original Music Composer |
| Richard L. Johnson | Supervising Art Director |
| Joseph Michael Tenga | Assistant Art Director |
| Eric de Jesus | Scenic Artist |
| Bruce Lee Gross | Leadman |
| Deborah Zimmerman | Set Costumer |
| Marc Connor | Scenic Artist |
| Diana Shaller | Scenic Artist |
| Julie Kuehndorf | Publicist |
| Denise Pinckley | Production Manager |
| Kathryn C. McGinnis | Scenic Artist |
| Mark Herman | Visual Effects Editor |
| Angela Quiles | Production Supervisor |
| Rachel Nemec | Assistant Art Director |
| Christopher Prampin | Gaffer |
| Ryan Heck | Assistant Art Director |
| Philippe Carr-Forster | Camera Operator |
| Scott Dougan | Assistant Art Director |
| Malchus Janocko | Assistant Art Director |
| Stephen Pardee | Set Costumer |
| Wendy Lee Roberts | Script Supervisor |
| Christopher Kay | Scenic Artist |
| Laura Wolford | Set Costumer |
| Elizabeth Himelstein | Dialect Coach |
| Daniel Carbo | Production Manager |
| Stephen Morahan | Assistant Art Director |
| Eric Lewis Beauzay | Assistant Art Director |
| David Stein | Assistant Art Director |
| Thomas Lappin | Camera Operator |
| Mark Pollard | Assistant Art Director |
| William Klayer | Camera Operator |
| Matthew Jeffrey Sama | Assistant Art Director |
| Max Grafe | Scenic Artist |
| Linda Drake | Visual Effects Editor |
| Petr Hlinomaz | Camera Operator |
| George Peters | Camera Operator |
| Avner Engel | Animation |
| Wayne Jaworskyj | Compositors |
| Mike Dharney | Animation |
| Kevin Webb | Animation |
| Jessica Wolff | Compositors |
| Jacob Jared Jones | Compositors |
| Aaron Williams | VFX Artist |
| Eddie Prickett | Animation |
| Joo-Hwan Park | Compositors |
| Kevin Kaska | Orchestrator |
| Michael Magill | ADR Editor |
| Sean Massey | Dialogue Editor |
| Sandy Hamilton | Property Master |
| David A. Cohen | Supervising ADR Editor |
| Robert Troy | Dialogue Editor |
| Teri E. Dorman | Supervising Dialogue Editor |
| David V. Butler | Dialogue Editor |
| Stan Lee | Executive Producer |
| Julia Davis | Stunts |
| BJ Davis | Stunts |
| Arturo Sandoval | Musician |
| Jerome Chen | Visual Effects Supervisor |
| E. Bennett Walsh | Executive Producer |
| Charlie Marroquin | Key Grip |
| Mike Yurich | Key Grip |
| Aaron Randall | Rigging Grip |
| Vincent Schicchi | Key Makeup Artist |
| Emmanuel Shiu | Concept Artist |
| Justin Claus Harder | Conceptual Design |
| Timothy Peel | Graphic Designer |
| Michael Powsner | Props |
| Andrew Sweeney | Dolly Grip |
| Carl Casano | Electrician |
| Boris Cifuentes | Electrician |
| Christopher B. Green | First Assistant Camera |
| Charley Gilleran | Key Grip |
| Edward Read | Lighting Programmer |
| LaLette Littlejohn | Makeup Artist |
| Josh Turi | Prosthetic Makeup Artist |
| Stephen M. Kelley | Makeup Artist |
| Joshua Min | Concept Artist |
| Jay Martin | Storyboard Artist |
| Matt Hedges | Camera Production Assistant |
| Loren Azlein | Camera Production Assistant |
| Gabe Munitz-Alessio | Electrician |
| Keith B. Davis | First Assistant "B" Camera |
| Glen A. Gregory | Carpenter |
| Henry Fong | Concept Artist |
| Steffen Reichstadt | Concept Artist |
| Daniel Boxer | Property Master |
| Abner Medina | Assistant Camera |
| Christian May | Best Boy Electric |
| Frank Duffy III | Electrician |
| Eric Boncher | Gaffer |
| Craig Nix | Libra Head Technician |
| Benoit Richard | Lighting Programmer |
| Cristina Patterson | Contact Lens Designer |
| Isaac Gabaeff | Props |
| Nick Haines-Stiles | Best Boy Grip |
| Gregory Michael Baney | Electrician |
| George Patsos | Key Grip |
| Eric Gearity | Key Rigging Grip |
| John L. Dardis | Lighting Technician |
| Jesse Pelikan | Rigging Grip |
| Robert O. Simons | Conceptual Design |
| Harvey Goldberg | Leadman |
| Robert Consing | Storyboard Artist |
| Tricia Mears | Camera Production Assistant |
| Brad Printz | Electrician |
| Spencer Snygg | Lighting Technician |
| David Chameides | Steadicam Operator |
| Jonathan Bach | Concept Artist |
| Aaron Sims | Concept Artist |
| Maki Takenouchi | Graphic Designer |
| Rob Riccobono | Electrician |
| Craig Vaccaro | Key Rigging Grip |
| Gavin Fernandez | Second Assistant "A" Camera |
| Zachary Ripps | Contact Lens Technician |
| Deidra Dixon | Hairstylist |
| Gregory Hill | Concept Artist |
| Luca Nemolato | Concept Artist |
| Jasen Joseph Sica | Key Hair Stylist |
| Christian Pearce | Concept Artist |
| Gabu Camilo | Props |
| Ryan Rodriguez | Best Boy Electrician |
| Richard MacDonald | Electrician |
| Jason Cortazzo | Libra Head Technician |
| Derek Murphy | Rigging Gaffer |
| Lisa Hazell | Hairstylist |
| Anthony Dunne | Carpenter |
| Christopher Rovira | Carpenter |
| Francesco Corvino | Concept Artist |
| Long Ouyang | Concept Artist |
| Jason Logerot | Painter |
| Jessie Pellegrino | Props |
| Brick Mason | Storyboard Artist |
| Phil Pastuhov | Aerial Director of Photography |
| Matthew Selkirk | Digital Imaging Technician |
| Christopher M. Elassad | Dolly Grip |
| James J. Ferris | Electrician |
| Jim Grout | Electrician |
| Daniel E. Joyce | Electrician |
| Jon D. Morrison | Electrician |
| Paul Colangelo | First Assistant Camera |
| Niko Tavernise | Still Photographer |
| Michael J. DiCarlo | Second Assistant Camera |
| Fríða Aradóttir | Hairstylist |
| Tina Khayat | Set Decorating Coordinator |
| Eric Dvorsky | Aerial Camera Technician |
| Ben Noftzger | Camera Production Assistant |
| Michael A. Leo | Generator Operator |
| Thomas Beczynski | Lighting Technician |
| Blaise Miller | Lighting Technician |
| Jared Krichevsky | Concept Artist |
| Ruby De Jesus | Props |
| Rick Marroquin | Dolly Grip |
| Inyoung Choi | Electrician |
| Mark Kahn | Generator Operator |
| Braden Belmonte | Second Assistant "A" Camera |
| Jelani Atu Wilson | Second Assistant "B" Camera |
| Sylvia James | Assistant Camera |
| Kevin Gilligan | Best Boy Grip |
| Chris Jones | Dolly Grip |
| Jerad Molkenthin | Electrician |
| Sergius Nafa | First Assistant "A" Camera |
| Patrick Fontana | Rigging Gaffer |
| Angel De Angelis | Hair Department Head |
| Tami Lane | Special Effects Makeup Artist |
| Kelton Cram | Concept Artist |
| Ben Mauro | Conceptual Design |
| Joseph S. Alfieri | Construction Coordinator |
| David Satin | Digital Imaging Technician |
| Sebastien Nicolet | Electrician |
| James Phelps | Electrician |
| George Selden | Electrician |
| John Oliveri | Second Assistant "B" Camera |
| Bruce McCleery | Second Unit Director of Photography |
| Sarah Rubano | Makeup Artist |
| J. Eric Camp | Digital Imaging Technician |
| Brett Heicher | Electrician |
| Nino Neuboeck | First Assistant "A" Camera |
| Willie Estrada | First Assistant Camera |
| Evan Nelson | Techno Crane Operator |
| Michael Nelson | Ultimate Arm Operator |
| Stephen Fitzgerald | Video Assist Operator |
| Adam Smelin | Video Assist Operator |
| Peter Montagna | Special Effects Makeup Artist |
| Michael Kutsche | Concept Artist |
| Scott Lukowski | Concept Artist |
| Valerie Nolan | Set Decoration Buyer |
| Hil Cook | Wigmaker |
| Ashley Beatty | Costumer |
| Sarah Yellin | Costumer |
| Chrissy Callan | Assistant Costume Designer |
| Rudy Mance | Costumer |
| Amy L. Teets | Costumer |
| Catharine Stuart | Set Costumer |
| Bryan Czerniawski | Costume Assistant |
| Christian Irles | Compositing Supervisor |
| Marvin Kim | Modelling Supervisor |
| Gavin Wright | Pre-Visualization Supervisor |
| Troy David | Ager/Dyer |
| Alexis Forte | Costume Assistant |
| Amy R. Burt | Costume Supervisor |
| Dani Phelps | Costumer |
| Wendy Yang | Costumer |
| Chris Waegner | CG Supervisor |
| Adam Ghering | Compositing Supervisor |
| Carmia Marshall | Set Costumer |
| Malcolm Phipps | Set Costumer |
| Michael Lerman | First Assistant Director |
| Glen Sylvester | Lead Animator |
| Patrick Smith | Pre-Visualization Supervisor |
| Brooke Bennett | Costume Assistant |
| Mairin Platt | Animation Coordinator |
| Matthew Kemper | Compositing Supervisor |
| Suzanne Pakier | Costumer |
| Hana Scott-Suhrstedt | Costumer |
| Tsigie White | Costumer |
| Harimander Singh Khalsa | Compositing Supervisor |
| David Alexander Smith | Digital Effects Supervisor |
| Jerad Marantz | Costume Illustrator |
| Deborah Zimmerman | Costumer |
| Erika Goyzueta | Set Costumer |
| David Schaub | Animation Supervisor |
| Steve Love | First Assistant Director |
| Max Tyrie | Lead Animator |
| Brian Kloc | Lighting Artist |
| Meghan Kasperlik | Assistant Costume Designer |
| Franny Bohar | Costume Assistant |
| Robert Winter | CG Supervisor |
| Stephen Borneman | Lighting Artist |
| Mitchell Travers | Assistant Costume Designer |
| Daryl Sawchuk | Animation Supervisor |
| Richard Spriggs | Lead Animator |
| Oleksandr Vozniuk | Lighting Artist |
| Valerie Klarich | Costume Coordinator |
| Laura Wolford | Costumer |
| Lucy Cobbs | Costumer |
| Wade Sullivan | Costumer |
| Srinath Tammina | 3D Modeller |
| Sarah Holden | Costume Assistant |
| Alicia Boue | Costumer |
| John Porto | Set Costumer |
| Angielette Smith | Set Costumer |
| David Paulin | Textile Artist |
| Bruce Moriarty | First Assistant Director |
| Stephane Paris | CG Supervisor |
| Martha Smith | Wardrobe Supervisor |
| Ed W. Marsh | Stereoscopic Supervisor |
| Ashley Lambert | ADR Voice Casting |
| Justin Jones | Stereoscopic Supervisor |
| Valeria di Gabriele | Visual Effects Coordinator |
| Jackie Snyder | Extras Casting Assistant |
| Stephen Edwards | Special Effects Technician |
| Joaquin Loyzaga | Special Effects Technician |
| Julius Kwan | Senior Animator |
| Oliver Allen-Wielebnowski | Stereoscopic Supervisor |
| Matthew DeJohn | Stereoscopic Supervisor |
| Ann Chow | Visual Effects Coordinator |
| Jean Ho | Visual Effects Coordinator |
| Jeffrey John Howard | Visual Effects Coordinator |
| Holly Price | Visual Effects Coordinator |
| Romy Webster | Visual Effects Coordinator |
| Greg DiGiacomo | Visual Effects Production Assistant |
| In-Ah Roediger | Senior Animator |
| Erik Nordby | Visual Effects Supervisor |
| H. Barclay Aaris | Special Effects Technician |
| Jack Mortellaro Jr. | Special Effects Technician |
| Mike Dharney | Senior Animator |
| Shu Fujita | Visual Effects Coordinator |
| Annie-Claude Lapierre | Visual Effects Coordinator |
| Bryan Godwin | Visual Effects Supervisor |
| Luke Botteron | VFX Editor |
| Maria Ximena Lozano | Visual Effects Coordinator |
| Adrian J. Sciutto | Visual Effects Coordinator |
| Grant Wilfley | Extras Casting |
| Pete Kelley | Special Effects Technician |
| Kurt Harris | Special Effects Technician |
| Joel Binder | Visual Effects Coordinator |
| Tyler Cordova | Visual Effects Coordinator |
| Rohan Tirkey | Stereoscopic Supervisor |
| Tom Driscoll | VFX Editor |
| Andrew Turner | Visual Effects Coordinator |
| Doug Oddy | Visual Effects Producer |
| Rori Bergman | Casting Associate |
| Jennifer Sabel | Background Casting Director |
| Nick Murphy | VFX Editor |
| Veronica Kablan | Visual Effects Coordinator |
| John Clinton | Visual Effects Producer |
| Rhonda C. Gunner | Visual Effects Producer |
| Madina Milana | Extras Casting |
| Claire Prebble | Special Effects Technician |
| Jessica Carrington | Visual Effects Coordinator |
| Josh Fritchie | Visual Effects Coordinator |
| Sam Marks | Visual Effects Coordinator |
| Meghan O'Brien | Visual Effects Coordinator |
| Megan Wong | Visual Effects Coordinator |
| Dakota Zantay | Extras Casting Assistant |
| Claudia Li | Visual Effects Coordinator |
| Jessica Lichtner | Script Supervisor |
| Sean Amborn | Special Effects Technician |
| Warren Dion Smith | Special Effects Technician |
| Cat Auburn | Special Effects Technician |
| Akhilesh Jain | Stereoscopic Supervisor |
| Hugh Brompton | Visual Effects Coordinator |
| Robin Garcia | Visual Effects Coordinator |
| Amanda Hui | Visual Effects Coordinator |
| Phelicia Sperrazzo | Visual Effects Coordinator |
| Jay Warren | Visual Effects Producer |
| Roland Blancaflor | Special Effects Technician |
| Alex Falkner | Special Effects Supervisor |
| Barry O'Brien | Stereoscopic Supervisor |
| Dan Cortez | Visual Effects Coordinator |
| Andrew Poole | Visual Effects Production Manager |
| Yelda Gürkan | Extras Casting Assistant |
| Jamie Rencen | Special Effects Technician |
| Kevin Krout | Colorist |
| Morning Star Schott | Digital Intermediate Producer |
| Dhirendra Chhatpar | Stereoscopic Editor |
| Mandy Arnold | Digital Intermediate Editor |
| Adesola Adeyeye | Production Coordinator |
| Kat Spiess | Assistant Editor |
| Elliot Graham | Additional Editor |
| Jason Fields | Assistant Editor |
| Priyal Mahadik | Stereoscopic Editor |
| Erin Davis | Digital Intermediate Producer |
| Vaibhav Marathe | Stereoscopic Editor |
| J. Wilfrid White | Marine Coordinator |
| Robert Mead | Additional Editor |
| Lauren Heath | Production Coordinator |
| Julie Solomon | Location Coordinator |
| Tekin Cetinkaya | Production Coordinator |
| Amanda O'Reilly | Production Secretary |
| Sachin Patidar | Online Editor |
| Robert Drwila | Assistant Editor |
| Neelkanth Mapara | Online Editor |
| Benjamin Sutor | Online Editor |
| Tamara Bally | Production Controller |
| Meghan K. Wicker | Production Coordinator |
| Sean Dunckley | Colorist |
| Brett M. Reed | First Assistant Editor |
| Harikrishna Dubey | Stereoscopic Editor |
| Al Cerullo | Pilot |
| Dawn Mountain | Travel Coordinator |
| Steven Saunders | Sculptor |
| Lisa Curtis Saunders | Software Engineer |
| Tom Holkenborg | Original Music Composer |
| Gary Archer | Prosthetics |
| Ted Chu | Camera Operator |
| Terry Leonard | Stunts |
| Robin Lynn Bonaccorsi | Stunt Driver |
| Kate Boyer | Stunts |
| Cassidy Vick Hice | Utility Stunts |
| Eileen Weisinger | Stunts |
| John Cenatiempo | Stunts |
| Chris Cenatiempo | Stunts |
| Jimmy N. Roberts | Stunts |
| Shawnna Thibodeau | Stunts |
| Danny Wynands | Stunts |
| Jodi Michelle Pynn | Stunts |
| Stan Lee | Comic Book |
| Steve Ditko | Comic Book |
| Addison Teague | Sound Designer |
